A5102774961- Ion channel regulation and function
- Venomous Animal Envenomation and Studies
- Advancements in Transdermal Drug Delivery
- Antibiotic Resistance in Bacteria
- Nicotinic Acetylcholine Receptors Study
- Antimicrobial Peptides and Activities
- Surfactants and Colloidal Systems
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Bacterial Genetics and Biotechnology
- Drug Solubulity and Delivery Systems
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Material Properties and Processing
- Escherichia coli research studies
- Electrospun Nanofibers in Biomedical Applications
- Plant Disease Management Techniques
- Dermatology and Skin Diseases
- Glycosylation and Glycoproteins Research
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Pharmaceutical and Antibiotic Environmental Impacts
- Block Copolymer Self-Assembly
- Sirtuins and Resveratrol in Medicine
- Moyamoya disease diagnosis and treatment
Shenyang Pharmaceutical University
2015-2025
Guangxi Normal University
2025
South China University of Technology
2025
Jiangxi Science and Technology Normal University
2024
University of Copenhagen
2024
Jiangxi University of Science and Technology
2022
Hebei Agricultural University
2011
Jilin Medical University
2008-2010
Beijing University of Technology
2010
Peking University People's Hospital
2010
Short peptide-based supramolecular assemblies have drawn much attention in the field of drug delivery.
Drug resistance is the leading problem in non-small-cell lung cancer (NSCLC) therapy. The contribution of histone methylation mediating malignant phenotypes NSCLC well known. However, role drug-resistance mechanisms remains unclear. Here, our data show that EZH2 and G9a, two methyltransferases, are involved drug NSCLC. Gene manipulation results indicate combination G9a promotes tumor growth mediates a complementary manner. Importantly, clinical study demonstrates co-expression both enzymes...
Lung cancer is a lethal malignancy lacking effective therapies. Emerging evidence suggests that epigenetic enzyme mutations are closely related to the malignant phenotype of lung cancer. Here, we identified series gain-of-function in histone methyltransferase DOT1L. The strongest them R231Q, located catalytic DOT domain. R231Q can enhance substrate binding ability Moreover, promotes cell growth and drug resistance cells vitro vivo. Mechanistic studies also revealed mutant specifically...
Abstract Polo-like kinase 1 (PLK1) signaling drives tumor malignancy and chemotherapy resistance, which is an unmet clinical need. Recruiting PLK1 to the central spindle during anaphase necessary for its function in promoting cancer cell proliferation, achieved by binding microtubule-associated protein regulating of cytokinesis (PRC1) located spindle. However, role PLK1/PRC1 resistance unknown. In this study, we identified a small molecule B4 inhibited through disrupting formation complexes....
Kidney renal clear cell carcinoma (KIRC) with poor prognosis is the main histological subtype of carcinoma, accounting for more than 80% patients. Most patients are diagnosed at an advanced stage due to being asymptomatic early on. Advanced KIRC has extremely its inherent resistance radiotherapy and chemotherapy. Therefore, a comprehensive understanding molecular mechanisms development effective diagnostic therapeutic strategies urgently needed. In this study, we aimed identify...
Abstract Glutathione peroxidase (GPX) is one of the important members antioxidant enzyme family. It can catalyze reduction hydroperoxides with glutathione to protect cells against oxidative damage. In previous studies, we have prepared human catalytic antibody Se‐scFv‐B3 (selenium‐containing single‐chain Fv fragment clone B3) GPX activity by incorporating a group Sec (selenocysteine) into binding site using chemical mutation; however, its was not very satisfying. order try improve activity,...
Scorpion venom contains a large variety of biologically active peptides. However, most these peptides have not been identified and characterized. Peptides with three disulfide bridges, existing in the scorpion venom, studied detail poorly characterized until now. Here, we report recombinant expression functional characterization two kinds (BmKBTx BmNaL-3SS2) bridges. This study adopted an effective Escherichia coli system. The genes for BmKBTx BmNaL-3SS2 were obtained by polymerase chain...