A5102902385- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Traditional Chinese Medicine Analysis
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Caveolin-1 and cellular processes
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Barrier Structure and Function Studies
- Peptidase Inhibition and Analysis
- Analytical Chemistry and Chromatography
- Conducting polymers and applications
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Plant biochemistry and biosynthesis
- Ginseng Biological Effects and Applications
- Vector-Borne Animal Diseases
- Pancreatic and Hepatic Oncology Research
- Nitric Oxide and Endothelin Effects
- Advanced Breast Cancer Therapies
- Photosynthetic Processes and Mechanisms
- Animal Disease Management and Epidemiology
Hebei Medical University
2016-2025
Fourth Hospital of Hebei Medical University
2016-2025
Ningxia Medical University
2023-2025
Peking University Shenzhen Hospital
2021-2025
University of Hong Kong - Shenzhen Hospital
2021-2025
Qiqihar Medical University
2016-2025
Beijing University of Chemical Technology
2024
Shandong University of Technology
2024
Binzhou Medical University
2007-2024
Binzhou University
2007-2024
This study aims to evaluate the safety and efficacy of BCMA-CD19 compound chimeric antigen receptor T cells (cCAR) dual reset humoral B cell immune system in patients with systemic lupus erythematosus (SLE) nephritis (LN).
Abstract Background Recent studies have illuminated the complexities of treating advanced bladder cancer (BCa), underscoring importance comprehending its molecular mechanisms for creating novel therapies. While role Karyopherin a2 ( KPNA2 ) in promoting BCa growth is established, precise mechanism remains elusive. Methods To investigate regulatory BCa, we employed a comprehensive approach integrating clinical case data and bioinformatics analysis to evaluate expression tissues. Mechanisms by...
Aim: The Wnt signaling pathway plays a pivotal role in cellular developmental processes and human carcinogenesis. aim of this study was to investigate the effects quercetin on growth colon carcinoma cell line regulation effect Wnt/β-catenin pathway. Methods: MTT assay used determine reduction viability SW480 cells clone 26 cells. apoptotic rate cell-cycle analysis after treatment with determnined by flow cytometry. Effects mRNA expression cyclin D1 survivin were detected semiquantitative...
Neuropeptides are a diverse and complex class of signaling molecules that regulate variety biological processes. provide many opportunities for the discovery new drugs targets treatment wide range diseases, thus, computational tools rapid accurate large-scale identification neuropeptides great significance peptide research drug development. Although several machine learning-based prediction have been developed, there is room improvement in performance interpretability proposed methods. In...
Abstract Currently approved HER2-targeting antibody-drug conjugates (ADCs) for HER2-positive breast cancer (BC) are associated with safety concerns. In this multicenter, single-arm, dose-escalation (phase 1a) and dose-expansion 1b) phase 1 trial (NCT03944499), patients HER2-expressing advanced solid tumors received FS-1502 (an anti-HER2 ADC) a 3 + design in 1a; metastatic BC at the recommended 2 dose (RP2D) 1b. The primary end points were dose-limiting toxicities (DLTs), maximum tolerated...
Although mature podocytes lack tight junctions, junction integral membrane protein claudin-5 (CLDN5) is predominantly expressed on plasma membranes of under normal conditions. Using podocyte-specific Cldn5 knockout mice, we identify CLDN5 as a crucial regulator podocyte function and reveal that deletion exacerbates injury proteinuria in diabetic nephropathy mouse model. Mechanistically, reduces ZO1 expression induces nuclear translocation ZONAB, followed by transcriptional downregulation WNT...
Nicotianamine (NA) plays a crucial role in transporting metal ions, including iron (Fe), plants; therefore, NICOTIANAMINE SYNTHASE (NAS) genes, which control NA synthesis, are tightly regulated at the transcriptional level. However, regulatory mechanisms of NAS genes require further investigations. In this study, we determined bZIP44 mediating plant response to Fe deficiency stress by conducting transformation experiments and assays. positively Arabidopsis interacting with MYB10 MYB72...
Introduction Tooth loss is associated with increased mortality risk; however, the mechanism underlying this still not clear. The objective of study was to explore whether frailty mediates association between tooth and risk among oldest old individuals. Methods participants were followed up from 1998 2018 in Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty constructed following a standard procedure. Mortality, frailty, applied as outcome, mediator, independent variables,...
Intestinal ischemia and reperfusion (I/R) is a clinical problem occurred for diverse causes with high mortality. Prophylaxis treatment of intestinal I/R remains challenge clinicians. The purpose the present study was to explore role Notoginsenoside R1 (R1), major component form Panax notoginseng, in management injury. induced male Sprague-Dawley rats by clamping superior mesenteric artery 90 min followed 60 or 3 days. (10 mg·kg −1 ·h ) administered either 20 before after reperfusion....
This study evaluated the structural characteristics, processing properties, and antioxidant properties of hydrolysates prepared from donkey milk (DM) whey protein using different proteases (Alcalase, Neutrase, papain, Flavourzyme). The results showed that enzymatic hydrolysis significantly increased hydrolysate solubility reduced average particle size compared to those DM protein. Neutrase Flavourzyme exhibited higher degrees (DH), along with elevated emulsification surface hydrophobicity....
Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, is activated a number malignancies. Rheumatoid arthritis (RA) characterized by chronic synovitis pannus formation associated with activation fibroblast-like synoviocytes (FLS). We investigated whether Shh plays role the proliferation FLS RA. Expression related components (Shh, Ptch1, Smo, Gli1) RA synovial tissues was examined immunohistochemistry (IHC) IHC,...
Hyperspectral remote sensing images (HSIs) have great research and application value. At present, deep learning has become an important method for studying image processing. The Generative Adversarial Network (GAN) model is a typical network of developed in recent years the GAN can also be used to classify HSIs. However, there are still some problems classification On one hand, due existence different objects with same spectrum phenomenon, if only according original generate samples from...
Background: Consumption of industrially produced trans-fatty acids (iTFAs) can result in alteration to lipid profile and glucose metabolism. Moreover, a diet high iTFAs could increase the risk obesity, cardiovascular diseases (CVDs) type 2 diabetes mellitus. Glucose metabolism are closely linked white adipose tissue (WAT), yet underlying mechanisms effect WAT poorly understood. Materials methods: Parameters homeostasis, profiles markers endoplasmic reticulum (ER) stress were measured rats...
3007 Background: KL590586 (A400/EP0031) is a potent next-generation selective RET inhibitor (SRI) with activity against acquired resistance mutations to first-generation SRIs, and brain metastases (mets). Here we present preliminary data of the phase Ⅰ part from I/II study (KL400-I/II-01, NCT05265091) in patients (pts) RET-altered advanced tumors define safety, pharmacokinetics (PK) efficacy. Methods: The KL400-I/Ⅱ-01 consisted dose-escalation (Bayesian Optimal Interval design)...