Ulcerative colitis (UC) is characterized by chronic inflammatory processes of the intestinal tract unknown origin. Current treatments lack understanding on how to effectively alleviate oxidative stress, relieve inflammation, as well modulate gut microbiota for maintaining homeostasis synchronously. In this study, a novel drug delivery system based metal polyphenol network (MPN) was constructed via coordination between epigallocatechin gallate (EGCG) and Fe

Aim: The Wnt signaling pathway plays a pivotal role in cellular developmental processes and human carcinogenesis. aim of this study was to investigate the effects quercetin on growth colon carcinoma cell line regulation effect Wnt/β-catenin pathway. Methods: MTT assay used determine reduction viability SW480 cells clone 26 cells. apoptotic rate cell-cycle analysis after treatment with determnined by flow cytometry. Effects mRNA expression cyclin D1 survivin were detected semiquantitative...

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of unknown aetiology affecting the colon and rectum. Pterostilbene (PS) has been reported as an effective antioxidant anti-inflammatory agent in preclinical IBD models. However, therapeutic outcomes PS are limited by potential side effects associated with systemic exposure modest bioavailability afforded its oral administration. These issues can be improved use intelligent responsive nanoparticles ability lysosome escape,...

ABSTRACT Objective This study aimed to evaluate the diagnostic ability of interleukin 2 (IL‐2) and interferon gamma (IFN‐γ) release assay induced by fusion protein (ESAT‐6/CFP‐10/Rv1985c) for detecting active tuberculosis (ATB) in clinically visiting patients. Methods A total 970 subjects (215 ATB group 755 non‐ATB group) underwent both an interferon‐γ (IGRA) a TB‐DNA PCR assay. Using clinical diagnosis as gold standard, qualitative quantitative test results IL‐2 IFN‐γ were analyzed....

Introduction Respiratory viral infection (RVI) is of very concern after the outbreak COVID-19, especially in pediatric departments. Learning pathogen spectrum RVI children previous epidemic COVID-19 could provide another perspective for understanding under current situation and help to prepare post control. Methods A nucleic acid sequence-based amplification (NASBA) assay, with 19 pairs primers targeting various respiratory viruses, was used multi-pathogen screening infections presenting...

Objective This study investigates the relationship between media usage patterns and anxiety levels, specifically examining how different profiles influence across various demographic groups. Methodology A total of 11,031 respondents from 120 cities China were classified into three profiles—Traditional Media-Dominant Users, New Omni-Media Users—using Latent Profile Analysis (LPA) based on their frequency. Demographic covariates excluded during initial profiling to ensure analysis focused...

Background/Objectives: To compare and analyze the application of a Helicobacter pylori (H. pylori, Hp) serum antibody typing test (Hp-sATT) 13C-urea breath (13C-UBT) in diagnosis Hp infection against an empirical therapy background. Methods: The detection Hp-sATT using combination quantum dot immunofluorescence method 13C-UBT was carried out 237 patients who visited Department Gastroenterology at Beijing Tsinghua Changgung Hospital. diagnostic consistency correlation with gastric lesions two...

Rationale: Ischemia-reperfusion-induced acute kidney injury (IR-AKI), characterized by the abrupt decline in renal function, is distinguished intricate interplay between oxidative stress and inflammation. In this study, a reactive oxygen species (ROS) scavenger-CF@PDA was developed to effectively target antioxidant anti-inflammatory pathways disrupt stress-inflammation cycle IR-AKI. Methods: UV-vis absorption spectra, FTIR TEM were employed determine successful construction of CF@P. ABTS,...

Personnel security is particularly important for public places where screening required, such as airports, railway stations and subway stations. To assist their staff in fast screening, a YOLOv5 network model incorporating Stem module, CGhost module Mixup data enhancement method improvement proposed the features cluttered item placement, contraband obscuration intentional concealment X-ray images. The introduced backbone of to replace first layer enrich improve feature expression capability...

Abstract Introduction Two methods were compared for evaluating the sigma metrics of clinical biochemistry tests using two different allowable total error (TEa) specifications. Materials and The imprecision (CV%) bias (bias%) 19 analytes calculated a trueness verification proficiency testing (TPT)‐based approach an internal quality control data inter‐laboratory comparison (IQC)‐based approach, respectively. sources (TEa), Clinical Laboratory Improvement Amendments 1988 (CLIA '88) People's...

Abstract Objective This study aimed to evaluate the system accuracy of four types blood glucose monitoring systems (BGMSs) and explore differences in acceptability each BGMS against five different standards. Methods The measurement values obtained from BGMSs (Roche Accu‐Chek ® Performa, Bayer Contour™ TS, Sinomedisite Glupad H1 Plus, Sinocare Gold‐Accu) were evaluated reference biochemical analyzer central laboratory. was determined using criteria specified standards, namely International...

Abstract Objective To evaluate the accuracy of Roche Accu‐Chek Performa glucose meters at a low concentration <5.55 mmol/L (100 mg/dL) over 9‐year period. Methods The concentrations was evaluated using annual comparison data for 9 consecutive years from 2015 to 2023, according acceptability criteria specified in International Organization Standardization (ISO) 15197:2013. Blood samples with were prepared by incubation and glycolysis. detected biochemical analyzer central laboratory....

We introduced a novel micro/nanofluidic chip platform (MNCP), which is based on an isothermal nucleic acid amplification method. This study aimed to evaluate the MNCP method for influenza A and B viruses detecting subtyping using throat swab samples from patients with influenza-like illness (ILI). total of 266 non-repeated ILI were tested three methods, MNCP, rapid diagnostic test (RIDT), real-time reverse transcription polymerase chain reaction (rRT-PCR). The results compared those obtained...

We retrospectively analyzed serum IgM antibodies (Abs) to influenza viruses from two tertiary hospitals in Beijing December 2016 February 2018. Samples 36,792 patients, aged 0–98 years, were collected and tested. Among the 923 children winter flu seasons assayed with both antigens Abs Flu A B assigned as paired groups. Another 2,340 adults 1,978 only antigen tested 2017 named unpaired Abs-positivity rates 0.80% 36.57% for B, respectively, peaking at 4–5 years of age. For adults, 10.34%...

Abstract Background Low concentration C‐reactive protein (CRP) has favorable prognostic significance in patients with cardiovascular risks. Methods We compared the wr‐CRP method hs‐CRP both on Roche Cobas c702 analyzer for determination of low CRP (<20 mg/L) including 200 treated Cardiology Department Beijing Tsinghua Changgung Hospital (Beijing, China) from December 2018 to March 2019. Results The two methods were highly correlated (Spearman's rho = 0.995). Deming regression was used fit...

Abstract Background Accurate and timely clinical laboratory critical values notification are crucial steps in supporting effective decision making, thereby improving patient safety. Methods A closed‐loop value system was developed by a multidisciplinary team of clinicians, laboratorians, administrators, information technology experts. All the that occurred at Beijing Tsinghua Changgung Hospital (BTCH, Beijing, China) from 2015 to 2019 were analyzed studied retrospectively. Results The total...

In view of the poor performance commonly used network models on self-made fire dataset and real-time requirements for detection, we propose an improved object detection model based YOLOv3-tiny lightweight network. The specific measures are as follows: Replace first four pooling layers in backbone with <tex>$3\times 3$</tex> convolutional a step size 2, increasing nonlinearity while reducing information loss caused by layer; On basis original layer, new layer <tex>$52\times 52$</tex> is added...

Abstract Background Fecal calprotectin (FC) is widely used to discriminate between patients with inflammatory diseases such as bowel disease (IBD) and functional irritable syndrome (IBS). ELISA a time‐consuming method for the measurement of FC, whereas fluorescent immunochromatography test can obtain results in around 30 minutes thus enables rapid response clinical decision. Methods Two methods, Proglead ® (FC Proglead) BÜHLMANN fCAL BÜHLMANN), were quantitatively examine FC 111 stool...