A5089083670- Alzheimer's disease research and treatments
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Advanced biosensing and bioanalysis techniques
- Cholinesterase and Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Ginseng Biological Effects and Applications
- Stochastic processes and statistical mechanics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Supramolecular Self-Assembly in Materials
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- NF-κB Signaling Pathways
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Pediatric Urology and Nephrology Studies
- Natural product bioactivities and synthesis
- Rabies epidemiology and control
- 14-3-3 protein interactions
Zhejiang Chinese Medical University
2018-2025
Inner Mongolia University
2019-2025
Sichuan University
2025
Fudan University
2025
West China Second University Hospital of Sichuan University
2025
Beijing Tsinghua Chang Gung Hospital
2024
Tsinghua University
2024
Inner Mongolia Medical University
2022-2024
Shanxi Academy of Medical Sciences
2020-2023
Tongji Hospital
2023
Fibrillization of α‐synuclein (α‐Syn) is closely associated with the formation Lewy bodies in neurons and dopamine (DA) a potent inhibitor for process, which implicated causative pathogenesis Parkinson's disease (PD). To elucidate any molecular mechanism that may have biological relevance, we tested inhibitory abilities DA several analogs including chemically synthetic natural polyphenols vitro . The MS NMR characterizations strongly demonstrate its inhibit α‐Syn fibrillization by where...
Taking a stand: Self-assembled peptide aggregates adopt interfacial orientations in which they either lie horizontally (on highly ordered pyrolytic graphite, hydrophobic) or are oriented upright mica, hydrophilic) to form nanofilaments with different heights. This process is controlled by the hydrophobic electrostatic interactions.
Introduction Respiratory viral infection (RVI) is of very concern after the outbreak COVID-19, especially in pediatric departments. Learning pathogen spectrum RVI children previous epidemic COVID-19 could provide another perspective for understanding under current situation and help to prepare post control. Methods A nucleic acid sequence-based amplification (NASBA) assay, with 19 pairs primers targeting various respiratory viruses, was used multi-pathogen screening infections presenting...
<title>Abstract</title> Lupus nephritis (LN) is a common kidney injury associated with systemic lupus erythematosus (SLE) and represents the most significant cause of disability mortality in SLE patients. Renal interstitial fibrosis pathological process leading to end-stage renal failure various chronic diseases. Paeoniflorin (PF) water-soluble monoterpenoid glycoside extracted from <italic>Paeonia lactiflora</italic>. Although there evidence that PF protects against LN, its underlying...
Following a constituent enrichment step on silica gel column, four phenyl-ethanoid glycosides were successfully isolated from Cistanches deserticola and purified by preparative high-speed counter-current chromatography (HSCCC) with two-phase solvent system composed of ethyl acetate-n-butanol-ethanol-water (40:6:6:50, v/v/v/v). A total 30.9 mg acteoside, 13.0 isoacteoside, 12.5 syringalide 3'-α-L-rhamnopyranoside 7.2 2'-acetylacteoside purity higher than 95%, as determined HPLC-ELSD, obtained...
Jieduquyuziyin prescription (JP) has been used to treat systemic lupus erythematosus (SLE). Although the effectiveness of JP in treatment SLE clinically proven, underlying mechanisms have yet be completely understood. We observed therapeutic actions MRL/lpr mice and their bone marrow-derived macrophages (BMDMs) potential mechanism inhibition inflammatory activity. To estimate effect on suppressing activity, BMDMs MRL/MP were treated with JP-treated serum, by for eight weeks. Among them, its...
We used network pharmacology, molecular docking, and in vitro experiments to explore the mechanisms of Astragali Radix treatment lupus nephritis. screened compounds targets Radix, as well related genes nephritis from databases. identified 211 common 44 between herb disease, constructed global, narrowed, hierarchical Compound-Target Interaction networks illustrate possible mechanism. found that PI3K/AKT/mTOR pathway is a core target gene set through enrichment analysis, PPI analysis MCODE...
Comorbidities, such as obesity, increase the risk of severe COVID-19. However, mechanisms underlying illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out (Leptin -/-) obese hamsters to establish a infection model. This model exhibits robust viral replication, lung lesions, pronounced clinical symptoms, and fatal infection, mirroring COVID-19 patients obesity. Using single-cell transcriptomics on tissues pre- post-infection, found that...
Autism is a severe neurodevelopmental disorder that characterized by impaired language, communication, and social skills. In regressive autism, affected children first show signs of normal language development but eventually lose these skills develop autistic behavior. Protein kinases are essential in G-protein-coupled, receptor-mediated signal transduction involved neuronal functions, gene expression, memory, cell differentiation. We studied the activity expression protein kinase A (PKA),...
Focal adhesion kinase (FAK) is involved in tumor cell migration and metastasis. However, the underlying mechanism remains unclear. Here, we present a signaling pathway regulation of melanoma by FAK. We found that interference FAK expression suppressed B16F10 migration/metastasis, altered expressions genes migration/metastasis. The down-regulation inhibited p-SrcY416, p-ERK1/2, Stat3 p-Stat3Y705, while promoted PPARγ, miR-125b E-cadherin. Then E-cadherin via p-SrcY416/p-ERK1/2/ p-Stat3Y705...
Focal adhesion kinase (FAK) is a non-receptor tyrosine involved in the development and progression of cancer. However, regulatory role FAK cell migration remains unclear. The aim present study was to investigate mechanism underlying regulation melanoma by FAK. effect knockdown on gene expression B16F10 cells examined chip analysis. levels coiled-coil domain containing 80 (CCDC80) epithelial (E)-cadherin were analyzed reverse transcription quantitative polymerase chain reaction western...
Gelsolin, a multifunctional actin-binding protein, forms complex with amyloid-β protein and reduces the amyloid load in transgenic mouse model of Alzheimer's disease (AD). Gelsolin consists six homologous domains, which have specific affinit
α‐Synuclein (α‐Syn), amyloid β‐protein and prion protein are among the amyloidogenic proteins that associated with neurodegenerative diseases. These three share a homologous region consensus sequence mainly consisting of glycine, alanine valine residues (accordingly named as GAV motif), which was proposed to be critical core for fibrillization cytotoxicity. To understand role motif in amyloidogenesis, we studied effects peptides corresponding (residues 66–74) on α‐Syn aggregation. The result...
Gelsolin exists as secretory (plasma) and cytoplasmic forms. We have reported that plasma gelsolin binds to amyloid β-protein (Aβ), inhibits its fibrillization. Others peripheral administration or transgene expression of reduces load in transgenic mouse models Alzheimer's disease. Here, we report the pheochromocytoma-12 cells increases after treatment with hydrogen peroxide. When synthetic Aβ was fortified cell lysate, co-immunoprecipitated Aβ. The results suggest forms a complex manner like...
Previous studies have shown that wild-type (wt) rabies virus (RABV) evades the host immune response by restricting expression of glycoprotein (G), which blocks activation dendritic cells (DCs) and induces production virus-neutralizing antibodies (VNAs). In present study, wt RABVs not only restricted G but also reduced incorporation into mature virions compared with laboratory-adapted viruses. A recombinant RABV expressing triple was used to further determine whether relates incorporation....
Japanese encephalitis virus (JEV) infection alters microRNA (miRNA) expression in the central nervous system (CNS). However, mechanism contributing to miRNA regulation CNS is not known. We discovered global degradation of mature mouse brains and neuroblastoma (NA) cells after JEV infection. Integrative analysis miRNAs mRNAs suggested that several significantly downregulated their targeted were clustered into an inflammation pathway. Transfection with 466d-3p (miR-466d-3p) decreased...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, and Jieduquyuziyin prescription (JP) traditional Chinese medicine (TCM) formula that has been testified to be effective for SLE treatment as an approved hospital many years in China. However, its mechanism of action the this disease largely unknown. The purpose study was determine whether JP-treated rat serum can inhibit activation peritoneal macrophages MRL/lpr mice by downregulating IRAK1 signaling pathway, thereby...