A5100403896- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Dialysis and Renal Disease Management
- Nephrotoxicity and Medicinal Plants
- Parathyroid Disorders and Treatments
- Gout, Hyperuricemia, Uric Acid
- Berberine and alkaloids research
- Traditional Chinese Medicine Studies
- RNA modifications and cancer
- Marine Bivalve and Aquaculture Studies
- Pharmacological Effects of Natural Compounds
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Photosynthetic Processes and Mechanisms
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Curcumin's Biomedical Applications
- Ocean Acidification Effects and Responses
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Plant Stress Responses and Tolerance
- Computational Drug Discovery Methods
Northwest University
2023-2025
Hubei University of Chinese Medicine
2013-2025
Hubei Provincial Hospital of Traditional Chinese Medicine
2013-2025
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Sichuan University
2006-2025
Xi'an Jiaotong University
2015-2025
Zunyi Medical University
2023-2025
Soochow University
2025
Fuzhou University
2004-2025
Tongde Hospital of Zhejiang Province
2024
Ulcerative colitis (UC) is characterized by chronic inflammatory processes of the intestinal tract unknown origin. Current treatments lack understanding on how to effectively alleviate oxidative stress, relieve inflammation, as well modulate gut microbiota for maintaining homeostasis synchronously. In this study, a novel drug delivery system based metal polyphenol network (MPN) was constructed via coordination between epigallocatechin gallate (EGCG) and Fe
Mitochondria are required for protecting host against pathogenic bacteria by activating mitochondrial unfolded protein response (UPRmt). Chlorogenic acid (CGA), a phenolic compound of green coffee extracts and tea has been shown to exhibit activities such as antioxidant, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, neuroprotective, anti-obesity. However, whether CGA regulates innate immunity the underlying molecular mechanisms remain unknown. In this study, we found...
Although a high incidence of cardiovascular disease (CVD) is observed among chronic kidney (CKD) patients in developed countries, limited information available about CVD prevalence and risk factors the Chinese CKD population. The Cohort Chronic Kidney Disease (C-STRIDE) was established to investigate patients.
Abstract Furanodienone, a major bioactive constituents of sesquiterpene derived from Rhizoma Curcumae , has been proven to possess the potent anticancer efficacy on human breast cancer cells. Here, we investigated cytotoxicity furanodienone colorectal carcinoma cell lines in vitro and vivo as well its underlying molecular mechanisms induction apoptosis. In this study, found that significantly inhibited proliferation RKO HT-29 cells, induced mitochondrial dysfunction characterized by collapse...
The widespread use of sulfonamide (SA) antibiotics in animal husbandry has led to residues SAs the environment, causing adverse effects ecosystem and a risk bacterial resistance, which is potential threat public health. Therefore, it highly desirable develop simple, high-throughput methods that can detect multiple simultaneously. In this study, we isolated aptamers with different specificities based on multi-SA systematic evolution ligands by exponential enrichment (SELEX) strategy using...
Sepsis-induced myocardial injury (SIMI), a common complication of sepsis, may cause significant mortality. Ferroptosis, cell death associated with oxidative stress and inflammation, has been identified to be involved in SIMI. This study sought investigate the role ANXA1 small peptide (ANXA1sp) SIMI pathogenesis. In this study, mouse cardiomyocytes (H9C2 cells) were stimulated lipopolysaccharide (LPS) imitate vitro. It was shown that ANXA1sp treatment substantially abated LPS-triggered H9C2...
Up-regulation of a disintegrin and metalloproteinase 10 (ADAM10) to prevent the formation β-amyloid (Aβ) peptides might be promising strategy treat Alzheimer's disease (AD). RNA G-quadruplex motif within 5'-UTR ADAM10 mRNA is an inhibitory element for translation. Thus, mitigation suppressive effect this using G-quadruplex-forming G-rich sequence (QGRS) binder new approach AD therapy. Herein, series methylquinolinium derivatives were synthesized screened by surface plasmon resonance (SPR)...
The simultaneous evolution of multiple aptamers can drastically increase the speed aptamer discovery. Most previous studies used same concentration for different targets, leading to dominance libraries by one or a few and low success rate. To foster best grow independently in sequence space, it is important (1) use target concentrations close their dissociation constants (2) stop at an early round before any starts dominate. In this study, we demonstrate affinity-guided selection concept...
Abstract Cold stress has adverse effects on plant growth and development. Plants respond acclimate to cold through various biochemical physiological processes, thereby acquiring tolerance. To better understand the basis for tolerance, we carried out a proteomic study in model moss, Physcomitrella patens , characterizing gametophore proteins with 2‐DE mass spectroscopy. Following exposure 0°C up 3 days, of more than 1000 protein spots reproducibly resolved, only 45 changed abundance by at...
Increasing evidence shows that SARS-CoV-2 can infect kidneys and cause acute kidney injury (AKI) in critically ill COVID-19 patients. However, mechanisms through which induces AKI are largely unknown, treatment remains ineffective. Here, we report kidney-specific overexpressing N gene AKI, including tubular necrosis elevated levels of serum creatinine BUN 8-week-old diabetic db/db mice, become worse those with older age (16 weeks) underlying disease (DKD). Treatment quercetin, a purified...
With the advancement of living standards, role healthy diets in maintaining well-being has gained prominence. The concept "medicinal fruits and vegetables" attracted much research attention recently. Medicinal vegetables are rich nutrients high edible value, also necessary for people's daily diet. In order to better exert effect medicinal prolong their shelf life, this paper reviews effects common thermal processing methods (boiling, steaming, microwaving, hot air drying, pasteurization) on...
We serendipitously discovered Zn
Background Acute kidney injury (AKI) is a serious complication of systemic inflammatory response syndrome (SIRS), which has high mortality rate. Previous studies showed that panaxadiol saponin (PDS) and Dexamethasone have similar anti-inflammatory properties protect cardiopulmonary function in lipopolysaccharide (LPS)-induced septic shock rats. In the present study, we investigated whether PDS or role improving LPS-induced AKI mice. Methods Results Mice subjected to LPS (10 mg/kg) treatment...
INTRODUCTION In Western medicine, the kidneys are primarily understood as anatomical organs essential for maintaining body's balance of substances. However, in traditional Chinese medicine (TCM), concept kidney is much broader. It encompasses not only but also a range functions related to tissues and organs, including reproduction, urination, nervous system, bones. TCM, believed store essence, govern water metabolism, support bone health, regulate breathing, influence hearing (opening into...