A5101476341- Polysaccharides and Plant Cell Walls
- Pharmacological Effects of Natural Compounds
- Polysaccharides Composition and Applications
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Microbial Metabolites in Food Biotechnology
- Ginseng Biological Effects and Applications
- Phytochemistry and biological activity of medicinal plants
- Microbial Natural Products and Biosynthesis
- Enzyme Production and Characterization
- Phytochemistry and Bioactive Compounds
- Toxin Mechanisms and Immunotoxins
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Bioactive Compounds and Antitumor Agents
- Hepatitis C virus research
- Traditional and Medicinal Uses of Annonaceae
- Trypanosoma species research and implications
- Traditional Chinese Medicine Analysis
- Marine Sponges and Natural Products
Tokushima University
2025
Kōchi University
2025
Tokyo University of Pharmacy and Life Sciences
2000-2024
Tokyo City University
2024
Kitasato University
2014-2023
Kitasato Institute Hospital
2009-2020
Tokyo Yamate Medical Center
2001-2020
Social Insurance Saitama Chuo Hospital
2020
keiyu Hospital
2017
Kogakuin University
2015
MRI studies using the manual tracing method have shown a smaller-than-normal hippocampal volume in patients with posttraumatic stress disorder (PTSD). However, these yielded inconsistent results, and brain structures other than hippocampus not been well investigated. A recently developed, fully automated called voxel-based morphometry enables an exploration of structural changes throughout by applying statistical parametric mapping to high-resolution MRI. Here we first used this technology...
A series of new antibiotics, Kinamycin A, B, C, and D which are mainly effective against gram-positive bacteria, were extracted with chloroform from the broth filtrate Streptomyces murayamaensis sp. nov. HATA et OHTANI. C (I), C24H20O10N2, m/e 496 (M+), was determined to have an 8-hydroxynaphthoquinone skeleton, nitrile, acetoxyl, tertiary methyl groups its ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) spectra, further found a unique structure N-C-N some chemical...
We studied the effect of parenteral pulse cyclophosphamide therapy in nine patients with active systemic lupus erythematosus and severe central nervous system involvement. Seven had focal neurological deficits and/or seizures associated abnormalities on cerebrospinal fluid analysis magnetic resonance imaging. Two organic brain syndrome psychosis normal imaging analysis. Six were unresponsive to treatment high dose corticosteroid. Cyclophosphamide, 0.75-1.0 g/m2 body surface area, was...
Exploration of the relationships between regional brain volume and anxiety-related personality traits is important for understanding preexisting vulnerability to depressive anxiety disorders. However, previous studies on this topic have employed relatively limited sample sizes and/or image processing methodology, they not clarified possible gender differences. In present study, 183 (male/female: 117/66) right-handed healthy individuals in third fourth decades life underwent structural...
Abstract Effects of an acidic polysaccharide fraction, BR-2, from the roots Bupleurum falcatum L., on HCl-ethanol, ethanol and water immersion stress-induced gastric lesions in mice pylorus-ligated ulcers rats have been studied. Oral administration BR-2 at doses 50 to 200 mg kg−1 inhibited formation induced by necrotizing agents such as HCl-ethanol ethanol, a dose dependent manner. This protective effect was observed after oral, intraperitoneal, subcutaneous (25–100 kg−1). also which were...
The aim of this paper was to further elucidate the structure and immunomodulating properties pectic polymer GOA2, previously isolated from Glinus oppositifolius. Enzymatic treatment GOA2 by endo-α-d-(1→4)-polygalacturonase led isolation three subunits, GOA2-I, GOA2-II, GOA2-III, in addition oligogalacturonides. GOA2-I shown consist 1,2-linked Rhap 1,4-linked GalpA an approximately 1:1 ratio, NMR-analysis showed that monomers were linked together a strictly alternating manner. galactose units...
Rosmarinic acid (RA) is one of major polyphenolic ingredients Perillae Herba (a leaf Perilla frutescens), and has an antidepressant-like property in animal models depression. However, the mechanism(s) underlying this activity are unknown. Recent studies have reported that regulation hippocampal neurogenesis associated with pathogenesis To elucidate mode action RA-induced activity, proliferative effect RA on newborn cells dentate gyrus mouse hippocampus was investigated using...