A5100706049- Epigenetics and DNA Methylation
- Endometriosis Research and Treatment
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Lipoproteins and Cardiovascular Health
- Nanoparticle-Based Drug Delivery
- COVID-19 Clinical Research Studies
Jiangxi Maternal and Child Health Hospital
2017-2025
Capital Medical University
2024-2025
Sun Yat-sen University
2022-2025
Capital University
2025
Versiti Blood Center of Wisconsin
2021-2025
Seoul School of Integrated Sciences and Technologies
2025
Sun Yat-sen Memorial Hospital
2022-2025
Guizhou University
2024-2025
Fudan University
2017-2025
Xidian University
2024-2025
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for of apurinic sites (AP sites). In non-small cell lung cancer (NSCLC), APE1 highly expressed and associated with poor patient prognosis. The suppression could lead to accumulation unrepaired DNA damage cells. Therefore, viewed as an important marker malignant tumors serve potent target development antitumor drugs. this study, we performed...
Apolipoprotein B (apoB)-lipoproteins initiate and promote atherosclerotic cardiovascular disease. Plasma tissue plasminogen activator (tPA) activity is negatively associated with atherogenic apoB-lipoprotein cholesterol levels in humans, but the mechanisms are unknown. We found that tPA, partially through lysine-binding site on its Kringle 2 domain, binds to N terminus of apoB, blocking interaction between apoB microsomal triglyceride transfer protein (MTP) hepatocytes, thereby reducing...
Background Lenvatinib plus PD-1 inhibitors and interventional (LPI) therapy have demonstrated promising treatment effects in unresectable hepatocellular carcinoma (HCC). However, biomarkers for predicting the response to LPI remain be further explored. We aimed develop a radiomics model noninvasively predict efficacy of therapy. Methods Clinical data patients with HCC receiving were collected our institution. The clinical was built information. Nine machine learning classifiers tested...
Folate, also known as vitamin B9, facilitates the transfer of methyl groups among molecules, which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal folate supplementation has been widely acknowledged its pivotal role in promoting cell proliferation preventing neural tube defects. However, post-fortification era, there a rising concern regarding an excess intake folic (FA), synthetic form folate. In this review, we focused on recent advancements understanding...
Abstract Elucidating in vivo lipolysis is crucial for clarifying the underlying mechanisms and fates of lipid‐based nanocarriers, which are essential oral drug delivery carriers. Current mainstream methodologies use various vitro digestion models to predict performance lipid formulations; however, their accuracy often impeded by complicated environment gastrointestinal tract. Although fluorescence labeling with conventional probes partly reveals translocation it fails elucidate process...
Gallic acid (3,4,5-trihydroxybenzoic acid; GA) is a naturally occurring plant polyphenol, isolated from water caltrop, which has been reported to exert anticancer effects. The present study investigated the antiproliferative effects of GA on HepG2 and SMMC‑7721 human hepatocellular carcinoma (HCC) cell lines using MTT colony formation assays. In particular, underlying mechanism GA‑induced apoptosis in cells was studied vitro by flow cytometry western blotting. results indicated that capable...
Isoacteoside (is a phenylethanoid isolated from Monochasma savatieri Franch. ex Maxim., which is an anti-inflammatory herb widely used in traditional Chinese medicine. However, the exact mechanism of activity isoacteoside not completely understood. In this study, its was elucidated mouse macrophages.The expression NF-κB pathway, MAPK iNOS, TNF-α, IL-6 and IL-1β evaluated using Western blotting, quantitative real-time PCR or ELISA. TLR4 dimerization determined by transfecting HEK293T cells...
Cellular responses to the graded Sonic Hedgehog (Shh) morphogenic signal are orchestrated by three Gli genes that give rise both transcription activators and repressors. An essential downstream regulator of pathway, encoded tumor suppressor gene Suppressor fused (Sufu), plays critical roles in production, trafficking, function proteins, but mechanism remains controversial. Here, we show Sufu is upregulated active Shh responding tissues accompanies translocating into repressors out nucleus....
Abstract Circular RNAs (circRNAs) have been implicated in tumorigenesis and progression of various cancers. However, the underlying mechanisms circRNAs hepatocellular carcinoma (HCC) not fully elucidated. Herein, a new oncogenic circRNA, hsa_circ_0070039 (circNUP54), was identified to be significantly upregulated HCC through circRNA sequencing. As verified 68 samples, circNUP54 overexpression correlated with aggressive cancerous behaviors poor outcomes. Moreover, function experiments showed...
Complete remission of colorectal cancer (CRC) is still unachievable in the majority patients by common fractionated radiotherapy, leaving risks tumor metastasis and recurrence. Herein, clinical CRC samples demonstrated a difference phosphorylation translation initiation factor eIF2α (p-eIF2α) activating transcription 4 (ATF4), whose increased expression initial X-ray irradiation led to resistance subsequent radiotherapy. The underlying mechanism studied radio-resistant CT26 cells, revealing...
As an important danger signal, the presence of DNA in cytoplasm triggers potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized key sensor for cytoplasmic DNA. The engagement cGAS with leads to synthesis second messenger, cyclic (cGAMP), which binds and activates downstream adaptor protein STING promote type I interferon production. Although has been shown play pivotal role innate immunity, exact regulation activation not fully understood. We report that E3...
Colorectal cancer (CRC) is one of top five leading causes cancer‑associated mortalities worldwide. 5‑Fluorouracil (5‑FU) the first‑line chemotherapeutic drug in treatment CRC; however, its antineoplastic efficiency limited due to acquired resistance. The regulatory mechanism underlying 5‑FU response and resistance CRC remains largely unknown. present study identified that silencing methyltransferase‑like 3 (METTL3) suppressed proliferation migration HCT‑8 cells. Using cell survival assays,...
The simultaneous evolution of multiple aptamers can drastically increase the speed aptamer discovery. Most previous studies used same concentration for different targets, leading to dominance libraries by one or a few and low success rate. To foster best grow independently in sequence space, it is important (1) use target concentrations close their dissociation constants (2) stop at an early round before any starts dominate. In this study, we demonstrate affinity-guided selection concept...