A5078681240- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Cancer-related gene regulation
Sun Yat-sen Memorial Hospital
2015-2025
Sun Yat-sen University
2015-2025
Sichuan University
2023
Southern Medical University
2014
Zhengzhou University of Light Industry
2010
University of Liège
2009
Failure of immune surveillance related to inadequate host antitumor responses has been suggested as a possible cause the high incidence recurrence and poor overall survival outcome hepatocellular carcinoma. The stress-induced heat shock proteins (HSPs) are known act endogenous "danger signals" that can improve tumor immunogenicity induce natural killer (NK) cell responses. Exosome is novel secretory pathway for HSPs. In our experiments, regulatory effect HSP-bearing exosomes secreted by...
MET signaling has been suggested a potential role in hepatocellular carcinoma (HCC) and associated with prometastasis during antiangiogenesis therapy. We investigated the association between expression therapeutic response to sorafenib patients HCC. Antitumor effects of cabozantinib, dual inhibitor VEGFR2, were examined cultured HCC cells as well vivo models.Total phosphorylated (p-MET) measured 29 resected specimens, correlated postoperative adjuvant In second set experiments using cells,...
Abstract Acquired resistance remains a bottleneck for molecular‐targeted therapy in advanced hepatocellular carcinoma (HCC). Metabolic adaptation and epigenetic remodeling are recognized as hallmarks of cancer that may contribute to acquired resistance. In various lenvatinib‐resistant models, increased glycolysis leads lactate accumulation lysine lactylation IGF2BP3. This is crucial capturing PCK2 NRF2 mRNAs, thereby enhancing their expression. process reprograms serine metabolism...
The deregulation of microRNAs (miRNAs) plays an important role in human hepatocarcinogenesis. In this study, we highlight exosomes as mediators involved modulating miRNA profiles hepatocellular carcinoma (HCC) cells. First, examined the different expression HCC cells and cell–derived exosomes. Next, coculture experiments indicated that promoted cell growth, migration, invasion had ability to shuttle miRNAs recipient Further, our data showed Vps4A, a key regulator exosome biogenesis, was...
The role of tumor necrosis factor alpha (TNF-α) in targeted therapy for hepatocellular carcinoma (HCC) remains largely unknown. current study aimed to clarify the mechanistic effects targeting TNF-α overcome sorafenib resistance HCC.A correlation expression with prognosis was analyzed 62 HCC patients who underwent surgical resection and subsequent received adjuvant treatment. relation sensitivity determined different cell lines. combined therapeutic ulinastatin, which could inhibit...
Background Lenvatinib plus PD-1 inhibitors and interventional (LPI) therapy have demonstrated promising treatment effects in unresectable hepatocellular carcinoma (HCC). However, biomarkers for predicting the response to LPI remain be further explored. We aimed develop a radiomics model noninvasively predict efficacy of therapy. Methods Clinical data patients with HCC receiving were collected our institution. The clinical was built information. Nine machine learning classifiers tested...
Gastrointestinal (GI) cancers account for over a quarter of all cancer-related deaths in the United States; however, latest trends their prevalence remain unclear. Data on GI were obtained from Global Burden Disease Study 2021. Age-standardized incidence rates (ASIR) and age-standardized mortality (ASMR) estimated across various states, sexes, ages, risk factors, annual percentage changes calculated. From 2000 to 2021, liver cancer exhibited greatest increase both ASIR ASMR, followed by...
Oncogenic KRAS plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) development and progression. However, the mechanism has not been clearly elucidated. RKIP is tumor repressor, loss of shown PDAC. Here, we found that expression was inversely correlated with PDAC fresh tissue regardless mutant status. The negative correlation between further confirmed our microarray. overexpression downregulation were associated poor clinical outcomes. Knockdown or cell lines robustly increased...
Lenvatinib has recently become available as the first-line therapy for advanced hepatocellular carcinoma (HCC), but its molecular mechanism in HCC remains largely unknown. The current study aims to identify mechanisms of lenvatinib HCC. Gene expression microarrays, flow cytometry, western blot, qRT-PCR, immunohistochemistry and immunofluorescence were used response cells lenvatinib. Xenograft tumor Huh7 was also established detect effect vivo. Herein, we found that could induce apoptosis via...
Despite the remarkable progress of metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named non-alcoholic (NAFLD), remains poorly improved. Since increased oxidative stress and inflammation contribute to initiation progression disorders, vitamin C (VC), an antioxidant agent, might be a suitable treatment option for MAFLD. However, lack clinically confirmed benefits makes clinicians challenging recommend supplements MAFLD individuals.Herein, nationally representative...
Abstract Circular RNAs (circRNAs) have been implicated in tumorigenesis and progression of various cancers. However, the underlying mechanisms circRNAs hepatocellular carcinoma (HCC) not fully elucidated. Herein, a new oncogenic circRNA, hsa_circ_0070039 (circNUP54), was identified to be significantly upregulated HCC through circRNA sequencing. As verified 68 samples, circNUP54 overexpression correlated with aggressive cancerous behaviors poor outcomes. Moreover, function experiments showed...
Cabozantinib, a small-molecule multitargeted tyrosine kinase inhibitor, has entered into phase III clinical trial for the treatment of hepatocellular carcinoma (HCC). This study assessed mechanistic effect cabozantinib on reversal P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). CCK-8 assays and tumour xenografts were used to investigate MDR in vitro vivo respectively. Substrate retention evaluated by fluorescence microscope flow cytometry. Western blotting was detect protein...
Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related death worldwide. In present study, we aimed to profile possible changes in plasma phospholipid fatty acid composition HCC patients, and identify biomarkers that could distinguish patients from healthy controls. A total 37 samples controls were collected their profiles characterized by gas chromatography-mass spectrometry followed multivariate statistical analysis. Twenty-five acids identified quantified,...
Circular RNAs have been reported to play essential roles in the tumorigenesis and progression of various cancers. However, biological processes mechanisms involved hepatocellular carcinoma (HCC) remain unclear. Initial RNA-sequencing data qRT-PCR results our cohort showed that hsa_circ_0072309 (also called circLIFR) was markedly downregulated HCC tissues. Kaplan-Meier analysis indicated higher levels circLIFR patients correlated with favorable overall survival recurrence-free rates. Both...
Smith-like (LSM) family members play critical roles in multiple oncologic processes several types of malignancies. The study on LSM HCC might provide new insights into the tumorigenesis and therapeutic strategies HCC.The clinical significance biological functions were assessed through bioinformatics methods vitro studies. potential correlation between tumor immunity was also investigated using single sample gene set enrichment analysis (ssGSEA) ESTIMATE algorithm.LSM member overexpression...
Abstract Backgrouds Immune checkpoint inhibitors (ICIs) resistance of solid tumors is common and subsequent treatment options offer limited clinical benefit. Anlotinib a novel multitarget tyrosine kinase inhibitor (TKI) for tumor angiogenesis proliferative signaling. Recent preclinical studies have suggested that anlotinib can reverse to ICIs by modulating the immunosuppressive microenvironment (TME). The current real-world study aimed investigate efficacy safety in Chinese patients who...
Abstract Purpose: Tyrosine kinase inhibitors (TKIs) combined with immune checkpoint blockades (ICBs) produce enhanced anti-tumor activity in the treatment of advanced hepatocellular carcinoma (HCC). Sitravatinib is a novel multi-target TKI that targets TYRO3, AXL, MERTK (TAM) receptors, c-MET, etc. This study aimed to investigate efficacy and immunomodulatory sitravatinib HCC. Experimental Design: Human HCC cell lines xenograft models were used explore sitravatinib. Subcutaneous orthotopic...
Liver regeneration (LR) happens after various types of injuries. Unlike the well‐studied LR caused by partial hepatectomy (PHx), there is accumulating evidence suggesting that during other injuries may result from unknown mechanisms. In this study, we found insulin‐like growth factor 2 (IGF‐2) was drastically induced following liver tyrosinemia or long‐term treatments CCl 4 . However, not observed early phase acute PHx single treatment Remarkably, most IGF‐2‐expressing hepatocytes were...