A5035926444- Hemophilia Treatment and Research
- Electrical and Bioimpedance Tomography
- Non-Invasive Vital Sign Monitoring
- ECG Monitoring and Analysis
- Hemodynamic Monitoring and Therapy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Muscle activation and electromyography studies
- Platelet Disorders and Treatments
- Cardiac pacing and defibrillation studies
- Psychosomatic Disorders and Their Treatments
- Sensor Technology and Measurement Systems
- Global Financial Crisis and Policies
- Suicide and Self-Harm Studies
- Credit Risk and Financial Regulations
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Pregnancy-related medical research
- Bacterial Infections and Vaccines
- Autoimmune Bullous Skin Diseases
- Vascular Anomalies and Treatments
- Graphene and Nanomaterials Applications
- Non-Destructive Testing Techniques
- Context-Aware Activity Recognition Systems
- Wireless Sensor Networks for Data Analysis
Indiana Hemophilia and Thrombosis Center
2020-2025
Poznań University of Economics and Business
2024
Indiana University Health
2019
Indiana University – Purdue University Indianapolis
2019
Pomeranian Medical University
2017
Gdańsk University of Technology
2009-2013
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2005
Introduction Surgery is frequently required in persons with haemophilia A (PwHA). Emicizumab, a bispecific, humanized monoclonal antibody, bridges activated factor (F) IX and FX. Management of patients undergoing surgery while receiving emicizumab clinical interest due to paucity data. Aim Review real-world experience PwHA with/without FVIII inhibitors who prophylaxis. Methods Data regarding peri-operative management, including type surgery, haemostatic agent use bleeding complications, were...
Apolipoprotein B (apoB)-lipoproteins initiate and promote atherosclerotic cardiovascular disease. Plasma tissue plasminogen activator (tPA) activity is negatively associated with atherogenic apoB-lipoprotein cholesterol levels in humans, but the mechanisms are unknown. We found that tPA, partially through lysine-binding site on its Kringle 2 domain, binds to N terminus of apoB, blocking interaction between apoB microsomal triglyceride transfer protein (MTP) hepatocytes, thereby reducing...
Recent technological innovations in haemophilia have advanced at an astounding pace, including gene therapy programmes and bioengineered molecules for prophylaxis, products that reduce treatment burden through half-life extension, unique mechanisms of action, subcutaneous administration. Additional advancements emerged are anticipated to further transform care.Review new emerging therapies, replacement bypassing products, digital applications, utilisation big data, personalised medicine.Data...
In this paper a simple method of measuring the pulse rate is presented. Elaborated algorithm allows for efficient registration directly from face images captured webcam. The desired signal obtained by proper channel selection and principal component analysis. To determine accuracy an ECG collected together with video recordings. effectiveness considered different regions interest, several combinations color channels lightening conditions. time components computation compared that independent...
With the rapid advancement of regenerative medicine technologies, there is an urgent need for development new, cell-friendly techniques obtaining nanofibers-the raw material artificial extracellular matrix production. We investigated structure and properties PCL10 nanofibers, PCL5/PCL10 core-shell type as well PCL5/PCLAg nanofibres prepared by electrospinning. For production fiber variants, a 5-10% solution polycaprolactone (PCL) (Mw = 70,000-90,000), dissolved in mixture formic acid acetic...
The aim of the study was to analyze relationships between variables: severity depression symptoms, feelings towards one's own body, dissociation, number and type traumatic life events experienced by adolescents who engage in deliberate self-injury are psychiatrically hospitalized.We examined 60 patients aged 13-17 (M = 15.48, SD 1.19). More than a half (55%) were diagnosed with mixed disturbance emotions conduct, 23.5% depressive behavior disorders, 10% episode. research tools:...
An electrode matrix and electronic circuit for simultaneous monitoring heart performance respiration activity is described in the paper. The evaluated basing on a mechanical electrical activity. measured using bioimpedance method while one typical approach, i.e. channel electrocardiogram recorded. exhibiting relatively low susceptibility to generating so called moving artifacts has been proposed examined. It was used measuring both, impedance signals. Spatial distributions of sensitivity...
The aim of the study was to analyze relationships between clinical variables (the severity depression symptoms, feelings towards body, dissociation, number and type traumatic events) deliberate self-injury functions. Moreover, we investigated whether group self-mutilating adolescents is internally diverse in terms how important individual functions self-mutilation are, subgroups singled out by these differ each other variables.The Inventory Statements about Self-Injury used....
While rare, vaccination-induced autoantibodies can occur outside of the pediatric population. This diagnosis should be considered after infectious and lymphoproliferative disorders are ruled out. Clinical management will depend on individual case, but all patients monitored closely.
ABSTRACT Among 1,272 H. influenzae isolates obtained from patients with lower respiratory tract infections, 5.6% were found to be encapsulated. The most common serotypes b (40.3%) and e (38.9%) followed by f (16.7%) d (4.1%). All encapsulated within a particular serotype showed high genetic homogeneity did not produce β-lactamases.
Effects of annual training cycle on the metabolic response to supra-maximal exercise test in beach volleyball players The aim this study was analyze effects sports physiological during consecutive phases cycle. carried out at onset each phase. VO 2 max determined by an indirect method using Ästand-Rhyming nomogram and biochemical analyses were performed before after Wingate test. Concentrations lactate capillary blood measured levels glucose, insulin, visfatin, resistin, thiobarbituric acid...
This paper describes numerical simulations of the influence conductivity changes inside a volume conductor on impedance measured its surface. A simple model based finite element method has been developed to estimate an applicability effective theory in human chest modeling. The consisted cylinder with two concentric spheres inside. Simulations were performed for cases: first geometry was changing and material properties constant within each subdomain, next, but values phase cardiac cycle. In...
Introduction Mobility, defined as active, controlled, multi-joint flexibility used in movement, is limited pregnant women due to problems with low back pain (LBP) and pelvic girdle (PGP). The Pregnancy Mobility Index (PMI) a tool for assessing mobility relation LBP/PGP. lack of Polish version the PMI test prompted transcultural adaptation conditions. aim study was evaluate measurement properties Index. Methods involved 121 aged 18–44. translation process accordance design. Reliability...
Abstract Introduction Eptacog beta is a novel human recombinant FVIIa approved for use in the United States, European Union, Kingdom and Mexico treatment control of bleeding patients with haemophilia A or B inhibitors (≥12 years). It also indicated perioperative care same patient population Europe Kingdom. Aim To assess incidence rebleeding review outcomes subjects enrolled phase 3 PERSEPT 1 clinical trial. Methods treat mild/moderate episodes (BEs), administered an initial 75 225µg/kg dose...
Preterm premature rupture of membranes (pPROM) before 22–24 weeks gestation is considered previable and poses a high risk to the chances successful delivery. Multicystic dysplastic kidney (MCDK) most common form dysplasia this organ, usually affecting 1 kidney. A prenatal suspicion MCDK requires escalation clinical process reference center qualified equipped for further diagnosis treatment. We present unique case pPROM at 19 in pregnancy complicated by fetal as an interesting obstetric...