A5041273923- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Polymer Synthesis and Characterization
- Antioxidant Activity and Oxidative Stress
- Insect Resistance and Genetics
- Nanoparticle-Based Drug Delivery
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Synthesis and biological activity
- Additive Manufacturing Materials and Processes
- Crystallization and Solubility Studies
- Effects of Radiation Exposure
- Porphyrin and Phthalocyanine Chemistry
- Redox biology and oxidative stress
- biodegradable polymer synthesis and properties
- Photodynamic Therapy Research Studies
- Insect Utilization and Effects
- Polysaccharides and Plant Cell Walls
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Circular RNAs in diseases
- Advancements in Transdermal Drug Delivery
Silesian University of Technology
2016-2025
National Institute of Standards and Technology
2023
Université de Lorraine
2023
Bioengineering Center
2017
The biological activity of nanosize silver particles towards oral epithelium-derived carcinoma seems to be still underinvestigated. We evaluated the influence low doses scale on proliferation and viability malignant epithelial keratinocytes in vitro, alone conjunction with plant alkaloid berberine. Cells human tongue squamous SCC-25 (ATCC CRL-1628), cultivated mixture Dulbecco's modified Eagle's medium, were exposed nanoparticles (AgNPs, concentrations from 0.31 10 μg/mL) a combination AgNPs...
Abstract The aim of this study was to assess the influence cisplatin and an extremely low frequency electromagnetic field (ELF‐EMF) on antioxidant enzyme activity lipid peroxidation ratio, as well level DNA damage reactive oxygen species (ROS) production in AT478 carcinoma cells. Cells were cultured for 24 72 h culture medium with cisplatin. Additionally, cells irradiated 50 Hz/1 mT ELF‐EMF 16 min using a solenoid source ELF‐EMF. amount ROS, superoxide dismutase (SOD) isoenzyme activity,...
The voltage-dependent anion channels (VDAC) play an essential role in the cross talk between mitochondria and rest of cell. Their implication cell life death has been studied extensively recent years. In this work we impact mitochondrial membrane (VDACs) on survival response to X-ionizing radiation (IR) human lymphoblastoid K562 cells.The inhibition VDACs was achieved by 4,4`-diisothiocyanostilbene-2,2`-disulfonic acid (DIDS) inhibitor vitro experiments including clonogenity assay,...
// Artur Cieślar-Pobuda 1, 2 , Mehrdad Rafat 3 Viktoria Knoflach 4 Magdalena Skonieczna 2, 5 Andrzej Hudecki 6 Małecki 7 Elżbieta Urasińska 8 Seaid Ghavami 9 Marek J. Łos 3, 1 Stem Cell Group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Institute Automatic Control, Silesian Technology, Gliwice, Poland LinkoCare Life Sciences AB, Mjärdevi Science Park, Linköping, Sweden Unit Neurobiology, Department Medical Biochemistry & Biophysics, Karolinska...
Colorectal cancer (CRC) is the second cause of death worldwide. The composition and enzymatic activity colonic microbiota can significantly affect effectiveness CRC chemotherapy. Irinotecan a drug widely used to treat colon cancer. However, transformation drug-glucuronide (SN-38G) back its active form (SN-38) by bacterial β-glucuronidase (GUS) constitutes primary reason for observed intestinal toxicity irinotecan. It was demonstrated that novel enzymatically extracted apple pectin (PC) might...
AMA Adamiec-Organisciok M, Wegrzyn Cienciala L, Magate N, Skonieczna Nackiewicz J. Resistance to death pathway induction as a potential targeted therapy in CRISPR/Cas-9 knock-out colorectal cancer cell lines. Gastroenterology Review/Przegląd Gastroenterologiczny. 2024. doi:10.5114/pg.2024.134872. APA Adamiec-Organisciok, M., Wegrzyn, Cienciala, L., Magate, N., Skonieczna, & Nackiewicz, (2024). https://doi.org/10.5114/pg.2024.134872 Chicago Malgorzata, Magdalena Lukasz Ngoni and Joanna...
Free radicals generated by mitochondria are candidates for mediating long-lasting effects of radiation on cells, including genetic instability. To better understand the significance reactive oxygen species (ROS) and nitrogen (RNS) in these long-term we assayed ROS RNS levels, mitochondrial membrane potential mass, frequency DNA strand breaks, apoptosis necrosis human leukemic cells (K562 HL60) after 12 Gy X irradiation. An increase intracellular level was observed immediately...
New type of carriers based on grafted poly(ionic liquid)s was designed for delivery ionically attached salicylates (Sal). Choline derived ionic liquid monomeric units were successfully introduced with various content in the side chains by controlled radical polymerization. Properly high amounts pharmaceutics polymer systems achieved well-fitted length and grafting degree chains. In aqueous solution graft copolymers self-assembled into spherical superstructures sizes up to 73 nm. Delivery...
p53 wild-type lung cancer cells can develop radiation resistance. Circular RNA (circRNA) consists of a family transcripts with exclusive structures. circRNA is critical in tumorigenesis and potential biomarker or therapeutic target. It uncertain how expression functions are regulated post-radiation cells.A549 H1299 were divided into p53-wt p53-KO groups by CRISPR/Cas9; both subjected to 4 Gy ionizing (IR: p53-wt-IR p53-KO-IR). RNA-seq, CCK8, cell cycle, other functional mechanism experiments...
Two gold(iii) complexes incorporating 2,2':6',2''-terpyridine derivatives have been synthesised and characterized, the possibility of tuning cytotoxic activity by structural modifications a terpy ligand has examined. Both [AuCl(4'-R1-terpy)](PF6)2 (1) [AuCl(4'-R2-terpy)](PF6)2 (2), where R1 is 2-pyridyl R2 3-pyridyl, show good anti-proliferative activities against HCT116, which are higher in relation to those free ligands, [AuCl(terpy)](PF6)2 standard anticancer drug cisplatin. The...
The aspiration to interact living cells with electronics challenges researchers develop materials working at the interface of these two distinct environments. A successful interfacing coating should exhibit both biocompatibility and desired functionality a bio-integrated device. Taking into account biodiversity, tissue be fine-tuned specific requirements bioelectronic systems. In this study, we pointed electrochemical doping conducting polymers as strategy enabling efficient manufacturing...
The development of selective delivery anticancer drugs into tumor tissues to avoid systemic toxicity is a crucial challenge in cancer therapy. In this context, we evaluated the efficacy combination nanocarrier pH-sensitivity and glycoconjugation encapsulated drugs, since both vectors take advantage tumor-specific Warburg effect. Herein, synthesized biodegradable diblock copolymer, poly(ethylene glycol)-hydrazone linkage-poly[R,S]-3-hydroxybutyrate, which could further self-assemble micelles...
Cell type, morphology, and functioning are key variables in the construction of efficient “drug-vehicle” hybrids magnetic drug delivery. Iron-encapsulated multiwall carbon nanotubes (Fe@MWCNTs) appear as promising candidates for theranostics due to situ chemical catalytic vapor deposition (c-CVD) synthesis, straightforward organic functionalization, nanoneedle (1D) behavior. Here, model were synthesized by exploring C- sp 2 chemistry ((1+2)-cycloaddition nitrenes amidation) outer MWCNT walls...