A5033236992- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- earthquake and tectonic studies
- Geochemistry and Geologic Mapping
- Advanced biosensing and bioanalysis techniques
- Plant tissue culture and regeneration
- Plant Molecular Biology Research
- CRISPR and Genetic Engineering
- Pediatric Hepatobiliary Diseases and Treatments
- interferon and immune responses
- RNA Interference and Gene Delivery
- Chromosomal and Genetic Variations
- Plant Virus Research Studies
- Isotope Analysis in Ecology
- Liver Diseases and Immunity
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Plant Disease Resistance and Genetics
- Weed Control and Herbicide Applications
- Animal Virus Infections Studies
- Plant Gene Expression Analysis
- Radioactive element chemistry and processing
- Cancer-related Molecular Pathways
- Geochemistry and Elemental Analysis
Chinese Academy of Agricultural Sciences
2011-2025
Chinese Academy of Sciences
2019-2025
Institute of Geology and Geophysics
2020-2025
China Tobacco
2019-2025
Henan University
2023-2025
Institut de physique du globe de Paris
2023-2025
Centre National de la Recherche Scientifique
2023-2025
Université Paris Cité
2023-2025
Tobacco Research Institute
2011-2025
University of Chinese Academy of Sciences
2019-2024
Molecular diagnosis of COVID-19 primarily relies on the detection RNA SARS-CoV-2 virus, causative infectious agent pandemic. Reverse transcription polymerase chain reaction (RT-PCR) enables sensitive specific sequences genes that encode dependent (RdRP), nucleocapsid (N), envelope (E), and spike (S) proteins virus. Although RT-PCR tests have been widely used many alternative assays developed, current testing capacity availability cannot meet unprecedented global demands for rapid, reliable,...
Cell wall catabolism during fruit ripening is under complex control and key for quality shelf life. To examine the role of abscisic acid (ABA) in tomato (Solanum lycopersicum) ripening, we suppressed SlNCED1, which encodes 9-cis-epoxycarotenoid dioxygenase (NCED), a enzyme biosynthesis ABA. suppress SlNCED1 specifically fruits, thus avoid pleiotropic phenotypes associated with ABA deficiency, used an RNA interference construct driven by fruit-specific E8 promoter. accumulation transcript...
Pathogenic viral infections represent a major challenge to human health. Host immune responses respiratory viruses are closely associated with microbiome and metabolism via the gut-lung axis. It has been known that host defense against influenza A virus (IAV) involves activation of NLRP3 inflammasome, however, mechanisms behind protective function not fully known. Here we show an isolated bacterial strain, Bifidobacterium pseudolongum NjM1, enriched in gut microbiota Nlrp3-/- mice, protects...
Abstract Bimodal synergistic therapy produces superadditive effect for enhanced therapeutic efficacy. However, how to efficiently and simultaneously deliver several kinds of agents is still challenging. A cancer cell membrane‐derived nanocarrier (mCas9‐sGNRs) proposed photothermal/gene (PTT/GT) by efficient delivery clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated protein 9 (Cas9) gold nanorods (GNRs). In this approach, Cas9 proteins can be loaded inside...
SWEET (Sugar Will Eventually be Exported Transporter) proteins play vital roles in the transport of sugars, contributing to regulation plant development, hormone signaling, and responses abiotic stress. In this study, we identified 57 NtSWEETs tobacco (Nicotiana tabacum L.), then their physicochemical properties, chromosomal localization, synteny, phylogenetic relationships, genomic structure, promoter cis-elements, protein interaction network, tissue specificity, expression pattern were...
Mitochondrial damage-associated molecular patterns (DAMPs) including mitochondrial DNA (mtDNA), TFAM (transcription factor A, mitochondrial), and ATP, which play crucial roles in the regulation of inflammatory environment human diseases. However, role DAMPs regulating tumor microenvironment (TME) remains unclear. Herein, we demonstrate that infiltration M2-type tumor-associated macrophages (TAMs) was correlated with resistance hepatocellular carcinoma (HCC) to sorafenib. We found cell-free...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes disease 2019, constitutes an emerging human pathogen of zoonotic origin. A critical role in protecting the host against invading pathogens is carried out by interferon-stimulated genes (ISGs), primary effectors type I interferon (IFN) response. All coronaviruses studied thus far have to first overcome inhibitory effects IFN/ISG system before establishing efficient viral replication. However, whether SARS-CoV-2 evades...
Endoreduplication is prevalent during plant growth and development, often correlated with large cell organ size. Despite its prevalence, the transcriptional regulatory mechanisms underlying transition from mitotic division to endoreduplication remain elusive. Here, we characterize ETHYLENE-RESPONSIVE ELEMENT BINDING FACTOR 4 (ERF4) as a positive regulator of through function repressor. ERF4 was specifically expressed in mature tissues which cells were undergoing expansion, but rarely young...
Ring around the rosy: A novel multifunctional disulfide-containing hyperbranched poly(amido amine) that is stimuli-responsive, biocompatible, biodegradable, and photoluminescent can assemble DNA into a well-defined nanoring with strong photoluminescence. The stimuli-responsive ring wall biocompatible controllably bioreducible; it has potential applications in gene drug delivery, molecular imaging. Detailed facts of importance to specialist readers are published as "Supporting Information"....
Glyphosate is a widely used non-selective, broad-spectrum, systemic herbicide by interfering with the biosynthesis of aromatic amino acids. However, emergence glyphosate-resistant weeds has driven need for enhanced resistance in crops. In this study, we engineered two mutant variants tobacco EPSPS gene through acid substitution (TIPS-NtEPSPS and P180S-NtEPSPS). These mutated genes were overexpressed under control CaMV35S promoters. Our results demonstrate that overexpression TIPS-NtEPSPS...
The advent of a new generation collision-cell multicollector inductively-coupled-plasma mass-spectrometers (CC-MC-ICP-MS), the Nu sapphire, has provided venue in achieving higher precision K isotopic compositions compared to older instruments. Here, we take advantage this technology report eight sediment reference materials. (reported as δ41K representing 41K/39K ratios) for these materials span range 0.2‰: -0.42 ± 0.04‰ (BCSS-1), -0.51 0.07‰ (MESS-1), and -0.43 0.01‰ (MESS-4) three marine...
Zircon has long been utilized as a geochronological tool for determining the age of rock formations. However, our recent discovery anomalously ‘young’ zircon grains (<81 Ma) within igneous rocks from Troodos ophiolite in Cyprus challenges conventional interpretations. These chronologically younger grains, hosted dated to 95-81 Ma, are ubiquitously distributed across all mafic lithologies, including gabbro, diabase, and pillow lava. Their morphology, trace element signatures, Hf isotope...
AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD+. However, role progression human cancers remains largely unexplored. Here, we elucidated clinical implications, biological functions, and molecular mechanisms hepatocellular carcinoma (HCC). We found that significantly upregulated HCC, which most probably caused by DNA hypomethylation downregulation miR-150-5p. High expression markedly associated with poor survival patients HCC. Knockdown impaired, while forced...
Two clinopyroxene megacrysts, DMP‐2 and DMP‐3, were collected from Cenozoic alkali basalts in the Hannuoba region of China. They characterised for major trace element compositions situ microanalysis. EPMA LA‐ICP‐MS analyses indicate homogeneity mass fractions both samples. Bulk using various techniques (XRF, ICP‐OES solution ICP‐MS) also reveal good consistency their data. They, thus, can be used as potential reference materials elemental Accordingly, are recommended thirty‐two elements.
Members of the plant-specific B3 transcription factor superfamily play important roles in various growth and developmental processes plants. Even though there are many valuable studies on genes other species, little is known about tobacco. We identified 114 proteins from tobacco using comparative genome analysis. These were classified into four subfamilies based their phylogenetic relationships, include ARF, RAV, LAV, REM subfamilies. The chromosomal locations, gene structures, conserved...
Objective Systemic lupus erythematosus (SLE) involves kidney damage, and the inflammasome‐caspase‐1 axis has been demonstrated to promote renal pathogenesis. The present study was designed explore function of Absent in Melanoma 2 (Aim2) protein SLE. Methods Female wild‐type Aim2 −/− , Ifnar1 Rag1 Asc mice ages 8–10 weeks received 1 intraperitoneal injection 500 μl pristane or saline, survival monitored twice a week for 6 months. Results absence but not led enhanced SLE that treatment....
Abstract Potassium (K) is an essential electrolyte for cellular functions in living organisms, and disturbances K+ homeostasis could lead to various chronic diseases (e.g. hypertension, cardiac disease, diabetes, bone health). However, little known about the natural distribution of stable K isotopes mammals their application investigate bodily and/or as biomarkers diseases. Here, we measured isotopic compositions (δ41K, per mil deviation 41K/39K from NIST SRM 3141a standard) brain, liver,...
Nonsyndromic biliary atresia (BA) is a rare polygenic disease, with autoimmunity, virus infection and inflammation thought to play roles in its pathogenesis. We conducted genome-wide association study 336 nonsyndromic BA infants 8900 controls. Our results validated the of rs17095355 ADD3 risk (odds ratio (OR) = 1.70, 95% confidence interval (95% CI) 1.49-1.99; p 4.07 × 10-11). An eQTL analysis revealed that allele was associated increased expression ADD3. Single-cell RNA-sequencing data...