A5066356419- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Multiple and Secondary Primary Cancers
- Medical Imaging and Pathology Studies
- Esophageal Cancer Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Cancer survivorship and care
- Pneumocystis jirovecii pneumonia detection and treatment
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Pain Management and Opioid Use
The University of Texas MD Anderson Cancer Center
2016-2025
Cancer Center of Hawaii
2023
University of Hawaii System
2023
Center for Cancer Research
2023
Cancer Research Center
2023
National Cancer Institute
2023
Southern Medical University
2011-2022
Xianning Central Hospital
2021
Hubei University of Science and Technology
2021
University of Iowa
2021
To understand the role of nuclear factor erythroid-2-related 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in non-small cell lung cancer (NSCLC), we studied their expression a large series tumors with annotated clinicopathologic data, including response to platinum-based adjuvant chemotherapy.We determined immunohistochemical Nrf2 cytoplasmic Keap1 304 NSCLCs its association patients' characteristics, 89 from patients who received neoadjuvant (n = 26) or chemotherapy 63). We...
Background Non-small cell lung cancer (NSCLC) represents the majority (85%) of cancers and is comprised mainly adenocarcinomas squamous carcinomas (SCCs). The sequential pathogenesis SCCs occurs through dissimilar phases as former tumors typically arise in periphery whereas latter normally near central airway. Methodology/Principal Findings We assessed expression SOX2, an embryonic stem transcriptional factor that also plays important roles proliferation basal tracheal cells whose restricted...
Abstract Purpose: Up-regulation of the receptor tyrosine kinase EphA2 has been shown in several epithelial cancers. Epidermal growth factor (EGFR) and K-Ras have reported to regulate vitro models, but this regulation never examined tumors from patients. Because established importance EGFR mutations non–small cell lung cancer (NSCLC), we investigated relationship between these type. The significance expression was further by testing for correlation with other clinical parameters. Experimental...
Recent studies defined a potentially important role of the microbiome in modulating pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized that antibiotic usage may predict outcomes patients with PDAC. retrospectively analyzed clinical data resectable or metastatic PDAC seen at MD Anderson Cancer from 2003 2017. Demographic, chemotherapy regimen use, duration, type, reason for indication were recorded. A total 580 studied, 342 resected 238 patients, selected our...
Abstract Overexpression of the receptor tyrosine kinase EphA2 occurs in non–small cell lung cancer (NSCLC) and a number other human cancers. This overexpression correlates with poor prognosis, smoking, presence Kirsten rat sarcoma (K-Ras) mutations NSCLC. In cancers, has been implicated migration metastasis. To determine if can promote NSCLC progression, we examined relationship proliferation lines metastases patient tumors. We also potential mechanisms involving AKT, Src, focal adhesion...
Objective: We prospectively examined the psychosocial predictors and decision-making process regarding contralateral prophylactic mastectomy (CPM) among women with sporadic breast cancer. Background: Increasing numbers of cancer are seeking CPM. Data limited about surgical factors that influence interest in Methods: Women early-stage unilateral (n = 117) were recruited before their first visit at MD Anderson completed questionnaires assessing knowledge CPM associated factors. After...
We evaluated the efficacy of using standard radiologic and histologic criteria to guide follow-up patients with lobular carcinoma in situ (LCIS), neoplasia (LN), or atypical hyperplasia (ALH). Patients high-risk benign lesions diagnosed on biopsy were presented reviewed a multidisciplinary clinical management conference from 1 November 2003 through September 2011. Associations between patient characteristics rates upgrade determined by univariate multivariate logistic models, times diagnosis...
Background and Purpose Roflupram improves cognition limits neuroinflammation in the brain. However, beneficial effects of roflupram on Parkinson's disease (PD) remain unknown. Therefore, we aimed to elucidate pharmacological mechanisms action ROF experimental models PD. Experimental Approach We used an vitro PD model SH‐SY5Y cells exposed 1‐methyl‐4‐phenylpyridinium iodide (MPP + ). Cell viability apoptosis were analysed via MTT assay flow cytometry. Mitochondrial morphology, mitochondrial...
The transcription factor TCF21 is involved in mesenchymal-to-epithelial differentiation and was shown to be aberrantly hypermethylated lung head neck cancers. Because of its reported high frequency hypermethylation cancer, further characterization the stages types nonsmall cell cancer (NSCLC) that are associated "second hits" were assessed.TCF21 promoter 105 NSCLC including various histologies smokers nonsmokers determined. In addition, loss heterozygosity mutational status examined....
Background: Innovations in surgical approaches and instrumentation for spinal stabilization have allowed radical resections of advanced neoplasms. Wounds that expose vital neural structures can devastating consequences. In this study, the authors present a paradigm shift way complex wounds spine are managed, where immediate, prophylactic muscle-flap reconstruction is provided, particularly those patients identified to be at high risk wound-healing complications. The purpose study was...
Abstract BACKGROUND: The effect of contralateral prophylactic mastectomy (CPM) on the survival patients with early‐stage breast cancer remains controversial. objective this study was to evaluate benefits CPM using a propensity scoring approach that reduces selection bias from nonrandom assignment in observational studies. METHODS: A total 3889 female stage I III were identified who treated at University Texas MD Anderson Cancer Center 1997 2009. We assessed association between and...
Magnetic resonance imaging (MRI) is recommended for women at high risk breast cancer. We evaluated the cost-effectiveness of alternative screening strategies involving MRI.
Purpose The incidence of contralateral prophylactic mastectomy (CPM) has continued to increase. We prospectively examined psychosocial outcomes before and up 18 months after surgery in women who did or not have CPM. Methods Women with unilateral, nonhereditary breast cancer completed questionnaires 1, 6, 12, surgery. Primary measures were worry cancer-specific distress. Secondary body image, quality life (QOL), decisional satisfaction, regret. Results A total 288 (mean age, 56 years; 58%...
Introduction: We aimed to determine the prevalence and landscape of germline mutations among patients with young-onset pancreatic ductal adenocarcinoma (PDAC) as well their influence in prognosis.Methods: Patients from two cohorts were studied, high-risk cohort (HRC), which included 584 PDAC who received genetic counseling at The University Texas MD Anderson Cancer Center, a general (GC) 233 metastatic patients. defined DNA sequencing on 13 known cancer susceptibility genes. determined,...