A5082116966- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Wnt/β-catenin signaling in development and cancer
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Bone health and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Kruppel-like factors research
- FOXO transcription factor regulation
- Axon Guidance and Neuronal Signaling
- Circular RNAs in diseases
- Muscle metabolism and nutrition
- Mechanisms of cancer metastasis
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and disorders
- Exercise and Physiological Responses
- Protein Tyrosine Phosphatases
Tianjin Medical University
2016-2025
Lee's Pharmaceutical (China)
2025
Tianjin Infectious Diseases Hospital
2016-2018
Tianjin University of Sport
2010-2011
miR-196b-5p plays a role in various malignancies. We have recently reported its function regulating adipogenesis. However, it remains to be clarified whether and how affects bone cells homeostasis. In this study, vitro functional experiments showed an inhibitory effect of on osteoblast differentiation. Mechanistic explorations revealed that directly targeted semaphorin 3a (Sema3a) inhibited Wnt/β-catenin signaling. SEMA3A attenuated the impaired osteogenesis induced by miR-196b-5p....
Detailed understanding of molecular mechanisms controlling adipogenesis is great importance to identify new targets for treating obesity. Emerging evidence suggests that long noncoding RNAs (lncRNAs) may play a pivotal role in adipogenesis. Here, we have identified novel lncRNA, Plnc1, which transcribed from position ~25,000 bp upstream the peroxisome proliferator-activated receptor γ2(PPAR-γ2) gene. Plnc1 abundantly expressed adipose tissue, and obese mice higher expression tissue than...
Abstract Recent emerging evidences revealed that epigenetic methylation of histone and DNA regulates the lineage commitment mesenchymal progenitor cells. This study was undertaken to delineate actions lysine demethylase 7A (KDM7A) on osteogenic adipogenic differentiation. Kdm7a expression up‐regulated in primary marrow stromal cells established ST2 line after treatment. Silencing endogenous blocked differentiation whereas promoted Conversely, overexpression wild‐type enhanced inhibited...
Aerobic exercise has beneficial effects on both weight control and skeletal muscle insulin sensitivity through a number of specific signaling proteins. To investigate the targets by which exerts its resistance, an approach proteomic screen was applied to detect potential different protein expressions from insulin-resistant mice after prolonged aerobic training their sedentary controls. Eighteen C57BL/6 were divided into two groups: 6 fed normal chow (NC) 12 high-fat diet (HFD) for 10 weeks...
Nuclear factor I-C (NFIC) has recently been identified as an important player in osteogenesis and bone homeostasis vivo. However, the molecular mechanisms involved have yet to be defined. In current study, Nfic expression was altered primary marrow stromal cells established progenitor lines after adipogenic osteogenic treatment. Overexpression of ST2, mesenchymal C3H10T1/2, inhibited differentiation, whereas it promoted differentiation. Conversely, silencing endogenous cell enhanced blocked...
Muscle-type carnitine palmitoyltransferase 1 (CPT1b) plays an important role in skeletal muscle mitochondrial fatty acid β-oxidation. A myocyte-specific enhancer factor (MEF2) site that binds MEF2A the promoter of Cpt1b has been identified. The aim this study is to determine whether expression regulated by MEF2 response exercise training.Twelve male, 14-week-old C57BL/6 mice underwent 6 weeks treadmill at 12 m min(-1), for 60 min day(-1), 5 days week(-1). Quadriceps muscles were analysed...
ABSTRACT Proper differentiation of bone marrow stromal cells (BMSCs) into adipocytes is crucial for maintaining skeletal homeostasis. However, the underlying regulatory mechanisms remain incompletely understood, posing a challenge treatment age‐related osteopenia and osteoporosis. Here, through comprehensive gene expression analysis during BMSC adipocytes, we identified forkhead transcription factor Foxk2 as key regulator this process. was significantly higher in inguinal epididymal white...
Abstract Neural EGFL-like 2 (NELL2) is a secreted protein known for its regulatory functions in the nervous and reproductive systems, yet role bone biology remains unexplored. In this study, we observed that NELL2 was diminished of aged ovariectomized (OVX) mice, as well serum osteopenia osteoporosis patients. vitro loss-of-function gain-of-function studies revealed facilitated osteoblast differentiation impeded adipocyte from stromal progenitor cells. vivo further demonstrated deletion...
Abstract Background: Nectin-4 is a tumor-associated antigen, which was observed in multiple cancer types, including bladder, breast, lung, pancreatic and ovarian cancer. Enfortumab Vedotin (EV) the first approved nectin-4 antibody-drug conjugate (ADC) with MMAE as its payload for treatment of urothelial carcinoma (UC). However, beyond UC, EV hasn’t been other indications. In addition, severe skin adverse reactions were reported EV-treated patients. There are several new ADCs development but...
Abstract B7H3 (CD276) belongs to the B7 superfamily of immune checkpoint molecules. It is present at low levels in most normal tissues but overexpressed a variety cancers, such as lung cancer, prostate breast head and neck squamous cell carcinoma, esophageal carcinoma. Notably, overexpression has been found be associated with poor prognosis broad spectrum malignant tumors, it become an attractive target for cancer therapy recent years. B7H3-targeted antibody-drug conjugates (ADCs), DS7300,...
miR-20a-5p has recently been identified to induce adipogenesis of established adipogenic cell lines in our previous study. However, its role and molecular mechanisms the regulation adipocyte lineage commitment bone marrow-derived stromal cells (BMSCs) still need be explored. In this report, we demonstrated expression was promoted gradually during differentiation BMSCs. We also confirmed that a positive function BMSCs by gain-of-function study with overexpression lentivirus or synthetic...
Abstract Background N-myc downstream regulated gene 1 (NDRG1) plays a role in variety of biological processes including differentiation osteoclasts. However, it is not known if and how NDRG1 regulates osteogenic marrow stromal progenitor cells. Methods Gene expression profiling analysis was performed to study the level Ndrg1 during adipogenic differentiation. Gain-of-function and/or loss-of function experiments were carried out proliferation cells mechanism underlying investigated. Finally,...