A5035729358- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical synthesis and alkaloids
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Marine Sponges and Natural Products
- Phytochemistry and Bioactivity Studies
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Mycorrhizal Fungi and Plant Interactions
- Cancer Treatment and Pharmacology
- Phytochemistry and Bioactive Compounds
- Synthetic Organic Chemistry Methods
- Microbial Metabolism and Applications
- Crystallography and molecular interactions
- Alkaloids: synthesis and pharmacology
- Metal-Catalyzed Oxygenation Mechanisms
- Medicinal plant effects and applications
- Steroid Chemistry and Biochemistry
- Entomopathogenic Microorganisms in Pest Control
- Oxidative Organic Chemistry Reactions
- Plant chemical constituents analysis
Minzu University of China
2022-2025
South Central Minzu University
2006-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2008-2023
Chengdu Third People's Hospital
2023
Chengdu Medical College
2023
Wind Power Engineering (Japan)
2022
Energy Storage Systems (United States)
2022
The University of Tokyo
2021-2022
KTH Royal Institute of Technology
2021
Shanghai Jiao Tong University
2021
Matsutakone (1), a novel sterol with an unprecedented polycyclic ring system, together new norsteroid matsutoic acid (2) were isolated from the fruiting bodies of Tricholoma matsutake. Their structures and absolute configurations assigned by extensive spectroscopic analyses computational methods. Bioassay results showed that compounds 1 2 exhibited inhibitory activities against acetylcholinesterase (IC50 20.9 μM for 1).
Non-heme iron and α-ketoglutarate-dependent (Fe/αKG) oxygenases catalyze various oxidative biotransformations. Due to their catalytic flexibility high efficiency, Fe/αKG have attracted keen attention for application as biocatalysts. Here, we report the biochemical structural characterizations of unusually promiscuous catalytically versatile oxygenase SptF, involved in biosynthesis fungal meroterpenoid emervaridones. The vitro analysis revealed that SptF catalyzes several continuous oxidation...
Abstract A variety of novel natural products with significant bioactivities are produced by the basidiomycete Boreostereum vibrans . In present study, we describe 16 oximes and oxime esters a vibralactone backbone, vibralactoximes, which were isolated from scale‐up fermentation broth B. Their structures determined through extensive spectroscopic analyses. These compounds represent first nature. The hypothetical biosynthetic pathway these was also proposed. Seven exhibited pancreatic lipase...
This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A–L, 1–12, from fruiting bodies Poland-collected edible mushroom Macrolepiota procera. The structures absolute configurations new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction analyses. Structurally, A–F, 1–6, are distinguished presence a rare "1-en-1,11-epoxy" moiety which has not been previously...
Eighteen new nor-isopimarane diterpenes, xylarinorditerpenes A-R (1-18), along with two previously reported compounds, 14α,16-epoxy-18-norisopimar-7-en-4α-ol (19) and the labdane-type diterpene agatadiol (20), were isolated from cultures of fungicolous fungus Xylaria longipes HFG1018 wood-rotting basidiomycete Fomitopsis betulinus. The structure elucidation relative configuration assignments 1-18 accomplished by interpretation spectroscopic data through computational methods. absolute...
BACKGROUND Ulcerative colitis (UC) is an inflammatory condition with frequent relapse and recurrence. Evidence suggests the involvement of SLC6A14 in UC pathogenesis, but central regulator remains unknown. AIM To explore role UC-associated pyroptosis. METHODS Quantitative real-time polymerase chain reaction (qRT-PCR), immunoblotting, immunohistochemical were used to assess human tissues. Lipopolysaccharide (LPS) was induce inflammation FHC NCM460 cells model enteritis, levels assessed....
Four new polycylic alkaloids, lucidimine A-D, were isolated from the fruiting bodies of Ganoderma lucidum. Their chemical structures established based on 1D and 2D NMR data as well HREIMS/HRESIMS analyses.
(+)- and (−)-ganodilactone (<bold>1</bold>), a pair of novel meroterpenoid dimers possessing unique 5′<italic>H</italic>-spiro[chroman-4,2′-furan]-2,5′-dione ring system were discovered from the fruiting bodies <italic>Ganoderma leucocontextum</italic>.
Irpexolidal (1), a triterpenoid with an unprecedented carbon skeleton, along its biogenetic-related compound irpexolide A (2), were isolated from the fruiting bodies of medicinal fungus Irpex lacteus. features 6/5/6/5/6/5-fused polycyclic skeletal system which arises eburicane-type triterpene by 6,7- seco-6,8- cyclo pattern. The structures 1 and 2 established means extensive spectroscopic techniques, ECD calculation, DP4+ probability based on GIAO NMR chemical shift calculations. plausible...
Two new Tricholoma terpenoids, tricholopardins A and B, were isolated from the fruiting bodies of basidiomycetes pardinum. Their structures elucidated by spectroscopic methods, as well electronic circular dichroism optical rotatory dispersion calculations. Tricholopardin potently inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with an IC50 0.08 μM. Its anti-inflammatory effects on three inflammatory mediators also evaluated. plausible biosynthetic pathway...
Two highly conjugated alkaloids xylaridines A (1) and B (2) were obtained as racemates from the fungus Xylaria longipes. They resoluted into optically pure enantiomers, respectively. Their structures determined by extensive spectroscopic analyses, X-ray diffraction, equivalent circulating density (ECD) calculations. Compound 1 possesses a 5/6/6/5/5 fused ring system with unique 2-azaspiro[4.4]nonane substructure. The hypothesis of biosynthesis pathways for 2 was proposed.
Abstract The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical investigation on co-cultures congeneric led to isolation eleven new vibralactone derivatives, hirsutavibrins A–K ( 1 – 11 ). structures were elucidated by extensive NMR HRESIMS spectroscopic analysis, computational methods. Hirsutavibrins A ) B 2 showed weak cytotoxicity against human lung cancer cell line A549. Hirsutavibrin D 4 moderate anti-nitric oxide activity...
The unusual fused β-lactone vibralactone was isolated from cultures of the basidiomycete Boreostereum vibrans and has been shown to significantly inhibit pancreatic lipase. In this study, a structure-based lead optimization resulted in three series 104 analogs, among which compound C1 exhibited most potent inhibition lipase, with an IC50 value 14 nM. This activity is more than 3000-fold higher that vibralactone. effect on obesity investigated using high-fat diet (HFD)-induced C57BL/6 J obese...
Five new triterpenoids, irpeksins A–E (1–5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well absolute configurations compounds established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1–4 are featured by a scaffold 1,10-seco- ring B aromatic eburicane (24-methyllanostane), compound 5 is characterized 1,10–9,11-diseco- eburicane, which represents unprecedented cleavage patterns in lanostane family....
AbstractThree new bisabolane sesquiterpenoids, inonotic acid A (1), 3-O-formyl (2), B (3), and one drimane sesquiterpenoid 3α,6β-dihydroxycinnamolide (4), were isolated from the fruiting bodies of mushroom Inonotus rickii. Their structures elucidated by means extensive spectroscopic methods. Compound 4 had moderate inhibitory activity on human colon cancer SW480 (IC50 = 20.4 μmol).Keywords:: rickiisesquiterpenoidcytotoxicity AcknowledgmentsThis project was financially supported National...
Six new lanostane-type triterpenoids, namely leucocontextins S–X (1–6), together with twelve known compounds, were isolated from the fruiting bodies of Ganoderma leucocontextum. Their structures established by MS and NMR data.