A5101826939- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Spinal Fractures and Fixation Techniques
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Dysraphism and Malformations
- Phytochemistry and Biological Activities
- Biological and pharmacological studies of plants
- Healthcare and Venom Research
- Esophageal Cancer Research and Treatment
- Pregnancy-related medical research
- Nerve Injury and Rehabilitation
- Hip disorders and treatments
- COVID-19 and healthcare impacts
- Gastric Cancer Management and Outcomes
- Facial Trauma and Fracture Management
- Spinal Hematomas and Complications
- Dental Radiography and Imaging
- Esophageal and GI Pathology
- 3D Printing in Biomedical Research
- Medical Imaging and Analysis
Huazhong University of Science and Technology
2017-2023
Union Hospital
2017-2023
Tongji Hospital
2022-2023
Union Hospital
2019-2023
Yunnan Observatories
2022
Wuhan Union Hospital
2019-2020
Nanjing University of Chinese Medicine
2020
Case Western Reserve University
2019
Cornell University
2019
Weihai Science and Technology Bureau
2018
Treatment options for adult spinal cord injury without radiographic abnormality (ASCIWORA) varied. Compression of ASCIWORA may more likely result from lesions such as edema and hemorrhage or contusion. This study aimed to explore the clinical effect early durotomy with duroplasty decompression in treatment severe ASCIWORA. Data 16 patients who underwent ( < 72 h) posterior laminectomy followed by June 2015 January 2017 were retrospectively analyzed. Patients' prognosis was analyzed American...
Developing multi-doped bioceramics that possess biological multifunctionality is becoming increasingly attractive and promising for bone tissue engineering. In this view innovative Sr2+/Fe3+co-substituted nano-hydroxyapatite with gradient doping concentrations fixed at 10 mol% has been deliberately designed previously. Herein, to evaluate their therapeutic potentials healing, novel SrFeHA/PCL scaffolds are fabricated by extrusion cryogenic 3D printing technology subsequent lyophilization....
Anterior column-posterior hemitransverse fractures are prevalent in the elderly and often associated with quadrilateral surface (QLS) comminution. Several special QLS buttress plates have been introduced, but evidence of their comparability traditional fixation devices is lacking. This biomechanical study aimed to compare devices.Anterior an isolated fragment were created on 24 composite hemipelves allocated 4 groups: (1) infrapectineal plate, (2) suprapectineal (3) reconstruction plate 3...
Abstract Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stable biological properties. Despite resemblance to mesenchymal (MSCs) terms of self-renew tri-lineage differentiation, ability IMRCs repair meniscus underlying mechanism remains undetermined. Here, we showed that demonstrated stronger immunomodulatory pro-regenerative potential than...
At present, the treatment of osteoporotic defects poses a great challenge to clinicians, owing lower regeneration capacity bone as compared with normal bone. The guided (GBR) technology provides promising strategy cure using bioactive membranes. decellularized matrix from small intestinal submucosa (SIS) has gained popularity for its natural microenvironment, which induces cell response.In this study, we developed heparinized mineralized SIS loaded morphogenetic protein 2 (BMP2)-related...
To report the technical aspects, radiographic results, and complications of a modified ilioinguinal approach for treatment bicolumnar acetabular fractures, especially involving quadrilateral plate.Retrospective review.Level I Trauma Center, Wuhan Union Hospital, China.Data from all fractures (n = 96) treated surgically were collected between January 2012 June 2015. According to exclusion criteria, 22 patients who had undergone single supra-ilioinguinal with minimum 1-year follow-up included...
A stem cell-derived mineralized extracellular matrix (ECM) may be a good strategy to endow scaffolds with bone microenvironment, thus inducing regeneration. However, it also faces some challenges, such as limited number of cells, additional wound for autologous cell isolation, and time consumption expansion. In this study, we designed novel tissue-derived ECM scaffold fabricated by depositing porcine small intestinal submucosa (SIS) on true ceramic (TBC), which was followed mineralization...
Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from root bark Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse model.Male apoE-deficient mice on C57BL/6J background received NLB (10 30 mg/kg) for 12 weeks. Compared with model group, treatment significantly reduced en face lesions total aorta areas. In RAW264.7 cells,...
Biomaterials with excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. Decellularized matrix from porcine small intestinal submucosa (SIS) has attracted particular attention for tissue regeneration because it strong effects retains plentiful bioactive components. However, inferior osteoinductivity osteoconductivity. In this study, we developed porous composite of SIS combined mesoporous glass (SIS/MBG) the goal improving mechanical biological...
Iliosacral screw fixation is a popular method for the management of posterior pelvic ring fractures or dislocations, providing adequate biomechanical stability. Our aim in this study was to describe use new patient-specific external template guide insertion iliosacral screws and evaluate efficacy safety technique compared with conventional fluoroscopy-guided technique. This retrospective patients incomplete complete disruptions who required fixation. For analysis, were divided into two...
Abstract Six new compounds, phochinenins A–F ( 1 – 6 ), dimerized from 9,10‐dihydrophenanthrene and dihydrostilbene through direct coupling or an oxygen bridge, along with eight known were isolated the whole plants of Pholidota chinensis. Their structures elucidated on basis extensive spectroscopic investigations (1D‐, 2D‐NMR, HR‐EI‐MS).
Decellularized matrix from porcine small intestinal submucosa (SIS) endows scaffolds with an ECM-like surface, which enhances stem cell self-renewal, proliferation, and differentiation. Mesoporous bioactive glass (MBG) is extensively recognized as excellent bio-ceramic for fabricating bone grafts.In the current study, SIS was doped on MBG scaffold (MBG/SIS) using polyurethane foam templating polydopamine chemistry method. To mimic bony environment of a natural matrix, ECM-inspired delivery...
Ideal bone tissue engineering scaffolds composed of extracellular matrix (ECM) require excellent osteoconductive ability to imitate the environment. We developed a mineralised tissue-derived ECM-modified true ceramic (TBC) scaffold for delivery aspartic acid-modified morphogenic protein-2 (BMP-2) peptide (P28) and assessed its osteogenic capacity. Decellularized ECM from porcine small intestinal submucosa (SIS) was coated onto surface TBC, followed by mineralisation modification (mSIS/TBC)....
Study Design. Retrospective observational cohort study. Objective. We explored the relationship between diffusion tensor imaging (DTI) parameters and prognosis in patients with acute traumatic cervical spinal cord injury (ATCSCI). Summary of Background Data. DTI has been used to diagnose injury; nevertheless, its role remains controversial. Methods. analyzed retrospectively 24 ATCSCI who were examined using conventional T2-weighted DTI. Fractional anisotropy (FA) apparent coefficient (ADC)...
We developed the method of cervical spinal cord decompression through durotomy followed by duroplasty and analyzed its efficacy. To develop a tactic for treatment severe injury(SCI) with extensive edema without intramedullary hematoma, to demonstrate effectiveness this method. From October 2016 January 2018, 17 operations were performed in spine patients SCI. Decompression laminectomy was done first group patients. In second group, after durotomy. A total patients, 16 males (94%) 1 female...