A5050170161- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Collagen: Extraction and Characterization
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- interferon and immune responses
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Food Allergy and Anaphylaxis Research
- Probiotics and Fermented Foods
- Monoclonal and Polyclonal Antibodies Research
- Cell death mechanisms and regulation
- Diet and metabolism studies
- Invertebrate Immune Response Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guang’anmen Hospital
2025
Bohai University
2025
Zhejiang University of Technology
2023-2024
Dalian Ocean University
2021-2024
Harbin Medical University
2010-2024
Third Affiliated Hospital of Harbin Medical University
2011-2024
Southeast University
2021-2023
State Key Laboratory of Digital Medical Engineering
2022-2023
New York Medical College
2023
Breast cancer stem cells (BCSCs) are tumor initiating that can self-renew and highly tumorigenic chemoresistant. Therefore, the identification of factors critical for BCSC function is vital development therapies. Here, we report DNMT1-mediated FOXO3a promoter hypermethylation leads to downregulation expression in breast cancer. functionally related inhibition FOXM1/SOX2 signaling consequent suppression BCSCs properties tumorigenicity. Moreover, found SOX2 directly transactivates DNMT1...
Abstract Resistance to Herceptin represents a significant challenge for successful treatment of HER2-positive breast cancer. Here, we show that in Herceptin-sensitive cells, FOXO3a regulates specific miRNAs control IGF2 and IRS1 expression, retaining basic IGF2/IGF-1R/IRS1 signaling. The activity maintains expression PPP3CB, subunit the serine/threonine-protein phosphatase 2B, restrict phosphorylation (p-FOXO3a), inducing - -targeting miRNAs. However, Herceptin-resistant p-FOXO3a levels are...
Cancer stem cells are enriched in triple-negative breast cancer (TNBC) tumor tissues, which present strong capacities of proliferation and tumorigenicity. The study detected the distribution cell markers cluster differentiation (CD)44/CD24 analyzed clinical outcomes different CD44/CD24 phenotypes patients with TNBC. Multivariate Cox regression analyses were performed regard to prognostic value CD44/CD24, aldehyde dehydrogenase 1 other baseline characteristics, including size, lymph node...
Abstract Metastasis remains the major obstacle to improved survival for breast cancer patients. Downregulation of FOXO3a transcription factor in is causally associated with development metastasis through poorly understood mechanisms. Here, we report that functionally related inhibition VEGF-A/NRP1 signaling and consequent suppression metastasis. We show directly induces miR-29b-2 miR-338 expression. Ectopic expression miR-29b-2/miR-338 significantly suppresses EMT, migration/invasion, vivo...
Abstract With the advantage of reversible shape‐morphing between two different permanent shapes under external stimuli, two‐way shape‐memory aerogel is expected to become a preferred for developing practical applications in actuators, sensors, robotics, and more. Herein, first liquid crystal elastomer (LCE)‐based prepared by an orthogonal heat light curing strategy coupled with intermediate mechanical stretching step. The differential scanning calorimetry, temperature‐varied wide‐angle X‐ray...
Gene amplification, which involves the two major topographical structures double minutes (DMs) and homegeneously stained region (HSR), is a common mechanism of treatment resistance in cancer initiated by DNA double-strand breaks. NHEJ, one DSB repair pathways, involved gene amplification as we demonstrated previously. However, involvement homologous recombination, another pathway, remains to be explored. To better understand association between HR detected activity DM- HSR-containing...
Certain antimicrobial preservatives (APs) have been shown to perturb gut microbiota. So far, it is not yet fully known that whether similar effects are observable for a more diverse set of APs. It also remains elusive if biogenic APs superior synthetic in terms safety. To help fill these knowledge gaps, the eleven commonly used and on microbiota glucose metabolism were evaluated wild-type healthy mice. Here, we found induced intolerance perturbed microbiota, irrespective their origin. In...
Abstract Background Fatigue is prevalent in breast cancer survivors and has profound effects on daily life. The interference of fatigue with endocrine therapy may be difficult to separate. This study investigates the prevalence severity identifies demographic, clinical, lifestyle factors associated cancer-related (CRF) patients undergoing an urban area. Methods Women stage I-IIIA were recruited asked participate (n = 371) study. 315 women who responded questionnaire (84.9%), 54 (17.1%) had...
Background Women with breast cancer treated aromatase inhibitors (AIs) may experience musculoskeletal symptoms that lead to discontinuation of effective therapy. The purpose the current study is evaluate clinical and genetic predictors for AIs-related adverse events(MS-AEs). Methodology Principal Findings We recruited 436 postmenopausal Chinese Han women receiving adjuvant AIs therapy early-stage hormone-sensitive cancer. Patients completed a self-administered questionnaire assessing...
Abstract Purpose: Squamous cell carcinoma of tongue (SCCT) is the most common type oral cavity carcinoma. Chemoresistance in SCCT common, and underlying mechanism remains largely unknown. We aimed to identify key molecules signaling pathways mediating chemoresistance SCCT. Experimental Design: Using a proteomic approach, we found that HSP27 was potential mediator for cells. To further validate this role HSP27, performed various mechanistic studies using vitro vivo models as well serum tissue...
Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with over 1.9 million new cases and 904,000 deaths in 2022. Chemotherapy primary treatment for CRC but often leads to myelosuppression, significantly affecting efficacy patient outcomes. Predictive tools chemotherapy-induced myelosuppression are currently lacking. Methods: This retrospective study analyzed 855 patients from Guang'anmen Hospital who received first-line chemotherapy (CapeOx, FOLFOX, FOLFIRI)...
Background Breast cancer patients treated with aromatase inhibitors (AIs) may experience musculoskeletal adverse events (MS-AEs). Several studies have confirmed that the RANKL/RANK/OPG signaling pathway plays a dominant role in bone health. Therefore, this study aimed to analyze relationship between serum levels of RANKL, OPG and their SNPs (single nucleotide polymorphisms) AI-related MS-AEs. Methodology Principal Findings Patients early stage, hormone-sensitive breast who were receiving AI...
Green banana flour (GBF) is rich in resistant starch that has been used as a prebiotic to exert beneficial effects on gut microbiota. In this study, GBF was evaluated for its capacity restore microbiota and intestinal barrier integrity from antibiotics (Abx) perturbation by comparing it natural recovery (NR) treatment. C57B/L 6 J mice were exposed 3 mg ciprofloxacin 3.5 metronidazole once day 2 weeks induce dysbiosis model. Then, intervention at the dose of 400 mg/kg body weight conducted...
Goals To assess the efficacy and safety of Chinese Medicine Prescription “W-LHIT” in subjects with simple obesity, to explore its potential mechanism action. Methods Thirty-seven patients aged 18 60 from Wei-En hospital (Weifang City, Shandong, China), participated a double blinded, placebo-controlled study. Subjects were randomly divided into 2 groups, treatment 19 placebo group. The group took capsules for two months, while control received capsules. Both groups accepted healthy lifestyle...