A5004124688- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Molecular Communication and Nanonetworks
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Face Recognition and Perception
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Biomedical and Engineering Education
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Explainable Artificial Intelligence (XAI)
- Primate Behavior and Ecology
- Biochemical Analysis and Sensing Techniques
- Multisensory perception and integration
- Genetics and Neurodevelopmental Disorders
- Sustainable Urban and Rural Development
- Spacecraft Dynamics and Control
- CRISPR and Genetic Engineering
- Artificial Intelligence Applications
- Nuclear Receptors and Signaling
Shenzhen Institutes of Advanced Technology
2018-2025
Chinese Academy of Sciences
2011-2025
University of Chinese Academy of Sciences
2011-2025
HKUST Shenzhen Research Institute
2023-2024
Shenzhen Maternity and Child Healthcare Hospital
2024
Southern Medical University
2024
Institute of Biophysics
2011-2018
Center for Excellence in Brain Science and Intelligence Technology
2018
Institute of Psychology, Chinese Academy of Sciences
2017
Northeast Forestry University
2015
On January 29, 2024, Elon Musk made a public announcement via social media about the successful implantation of Neuralink device in humans. Shortly after, collaborative team from Xuanwu Hospital and Tsinghua University China revealed advancements their clinical experiment testing Neural Electronic Opportunity (NEO)—a wireless brain-computer interface (BCI).1Deng C. Li X. Dai J. Challenges for translating implantable to medical device.Innovat. Med. 2023;...
No well-established biomarkers are available for the clinical diagnosis of major depressive disorder (MDD). Vitamin D-binding protein (VDBP) is altered in plasma and postmortem dorsolateral prefrontal cortex (DLPFC) tissues MDD patients. Thereby, role VDBP as a potential biomarker was further assessed. Total extracellular vesicles (EVs) brain cell-derived EVs (BCDEVs) were isolated from first-episode drug-naïve or drug-free patients well-matched healthy controls (HCs) discovery (20 20 HCs)...
In visual perception, object identification requires both the ability to define regions of uniform luminance and zones contrast. Neural processes underlying contrast detection have been well studied, while those defining remain poorly understood controversial. Partially because stimuli comprised are relatively ineffective in driving responses cortical neurons, little effort has made systematically compare individual neurons Using large static stimuli, modulated temporally or contrast, we...
•Chemogenetic activation of hypothalamic neurons lowers the core body temperature monkeys.•Hypothermia is concomitant with a cohort robust cold-defense behaviors.•fMRI delineates brain-wide network as result targeted neuronal activation.•This group functionally conserved in rodents and monkeys.•This leap toward human torpor its application medicine space. Maintaining within narrow range vital for warm-blooded animals. In rodents, preoptic area (POA) hypothalamus detects regulates...
Abstract Timing perception is a fundamental cognitive function that allows organisms to navigate their environment effectively, encompassing both prospective and retrospective timing. Despite significant advancements in understanding how the brain processes temporal information, neural mechanisms underlying these two forms of timing remain largely unexplored. In this study, it aims bridge knowledge gap by elucidating functional roles various neuronal populations striatum prefrontal cortex...
Attracted by the appealing advantages of optogenetics, many nonhuman primate labs are attempting to incorporate this technique in their experiments. Despite some reported successes a few groups, still find it difficult develop reliable way transduce cells monkey brain and subsequently monitor light-induced neuronal activity. Here, we describe methodology that have developed successfully deployed on regular basis with multiple monkeys. All devices accessories easy obtain results using these...
<title>Abstract</title> Yohimbine, a potent alpha2A-adrenergic receptor (α2AAR) antagonist, was found to carry therapeutic potential for type 2 diabetes through improving insulin release. However, adverse side effects mediated by its actions in the brain hampered use. Here, we have developed novel peripherally acting α2AAR CDS479-2, based on molecular docking analysis and modification of yohimbine's structure. The inactive-state structures α2AAR, either bound yohimbine, or were elucidated...
When attempting to concurrently perform two distinct cognitive tasks, the performance of either task is frequently compromised. This phenomenon known as dual-task interference. Although multiple features have been postulated influence on interference, primary determinant remains unclear. The factor causing interference an important issue understand its mechanism and associated functions including switching tasks planning order. present study investigated this using monkeys three behavioral...
Non-human primates (NHPs) are extensively utilized to investigate the neural mechanisms underlying face processing; however, measuring their brain activity necessitates a diverse array of technologies. Pupillometry emerges as convenient, cost-effective, and non-invasive alternative for indirectly assessing activity. To evaluate efficacy pupillometry in facial emotional processing NHPs, this study designed fixation task experimental monkeys (Rhesus macaque) recorded variations pupil size...
Accurately recognizing facial expressions is essential for effective social interactions. Non-human primates (NHPs) are widely used in the study of neural mechanisms underpinning expression processing, yet it remains unclear how well monkeys can recognize other species such as humans. In this study, we systematically investigated process conspecifics and humans using eye-tracking technology sophisticated behavioral tasks, namely temporal discrimination task (TDT) face scan (FST). We found...
Promoters are essential tools for basic and translational neuroscience research. An ideal promoter should possess the shortest possible DNA sequence with cell-type selectivity. However, whether ultra-compact promoters can offer neuron-specific expression is unclear. Here, we report development of an extremely short that enables selective gene in neurons, but not glial cells, brain. The originates from human CALM1 only 120 bp size. (pCALM1) embedded adeno-associated virus (AAV) genome...
Consciousness lies at the heart of our existence and experience. To probe how perceptual consciousness emerges in brain, we recorded brain-wide intracranial electroencephalography signals from human patients while their was effectively manipulated using continuous flash suppression paradigm. We observed substantial differences brain activities when visual information gradually enters consciousness. Specifically, functional connectivity first increases then decreases, oscillations...
Abstract INTRODUCTION More robust non‐human primate models of Alzheimer's disease (AD) will provide new opportunities to better understand the pathogenesis and progression AD. METHODS We designed a CRISPR/Cas9 system achieve precise genomic deletion exon 9 in cynomolgus monkeys using two guide RNAs targeting 3′ 5′ intron sequences PSEN1 9. performed biochemical, transcriptome, proteome, biomarker analyses characterize cellular molecular dysregulations this model. RESULTS observed early...
ABSTRACT The ability to rapidly recognize basic facial emotions (e.g. fear) is crucial for social interactions and adaptive functioning. To date, the origin of facial-emotion-recognition remains equivocal. Using a classical twin design in humans, we found clear dissection low high spatial frequencies (LSF HSF) emotion perception: whereas genetic factors contributed individual variation LSF processing, HSF processing largely shaped by environmental effects. Furthermore, content genetically...