A5074728164- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Molecular Communication and Nanonetworks
- Advanced Memory and Neural Computing
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Energy Harvesting in Wireless Networks
- Transcranial Magnetic Stimulation Studies
- Anatomy and Medical Technology
- Muscle activation and electromyography studies
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Conducting polymers and applications
- Optical Imaging and Spectroscopy Techniques
- Topological and Geometric Data Analysis
- Neurogenesis and neuroplasticity mechanisms
University of Washington
2018-2025
Tohoku University
2023
Oregon National Primate Research Center
2019-2021
University of California, San Francisco
2013-2020
Seattle University
2018
University of California, Berkeley
2016
University of Michigan
2007-2013
Wayne State University
2007
Henry Ford Health System
2007
University of Tehran
2005
Brain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While local effects have been an active area investigation, on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics two macaques. A optogenetic interface enabled simultaneous excitatory neurons electrocorticographic recording across primary somatosensory (S1) motor (M1) cortex (Yazdan-Shahmorad et al., 2016). tracked measures connectivity, response...
In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Previous work has shown that parenchymal delivery of adeno-associated virus (AAV) in the thalamus by convection-enhanced (CED) can lead to large-scale transduction via axonal transport distal including cortex. We used this approach obtain widespread expression light-sensitive ion channels.AAV co-expressing channelrhodopsin-2 (ChR2) yellow fluorescent...
Lesioning and neurophysiological studies have facilitated the elucidation of cortical functions mechanisms functional recovery following injury. Clinical translation such is contingent on their employment in non-human primates (NHPs), yet tools for monitoring modulating physiology are incompatible with conventional lesioning techniques. To address these challenges, we developed a toolbox validated seven macaques. We introduce photothrombotic method inducing focal lesions, quantitative model...
In non-human primate (NHP) optogenetics, infecting large cortical areas with viral vectors is often a difficult and time-consuming task. Here, we demonstrate the use of magnetic resonance (MR)-guided convection enhanced delivery (CED) optogenetic into primary somatosensory (S1) motor (M1) cortices macaques to obtain efficient, widespread expression light-sensitive ion channels. Adeno-associated (AAV) encoding red-shifted opsin C1V1 fused yellow fluorescent protein (EYFP) were injected cortex...
Abstract A multi-modal neural interface capable of long-term recording and stimulation is essential for advancing brain monitoring developing targeted therapeutics. Among the traditional electrophysiological methods, micro-electrocorticography (μECoG) appealing chronic applications because it provides a good compromise between invasiveness high-resolution recording. When combining μECoG with optical technologies, such as calcium imaging optogenetics, this approach enables simultaneous...
Abstract A multimodal neural interface integrating electrical and optical functionalities is a promising tool for recording manipulating neuronal activity, providing multiscale information with enhanced spatiotemporal resolution. However, most technologies implementation are limited in their applications to small animal models lack the ability translate larger brains, such as non-human primates (NHPs). Recently, we have developed large-scale NHPs, Smart Dura, which enables...
Optogenetics is a powerful neuroscientific tool which allows neurons to be modulated by optical stimulation. Despite widespread optogenetic experimentation in small animal models, optogenetics non-human primates (NHPs) remains niche field, particularly at the large scales necessary for multi-regional neural research. We previously published large-scale, chronic cortical interface NHPs was successful but came with number of limitations. In this work, we present an optimized improves upon...
Objective. Cortical electrical stimulation (CES) has been used extensively in experimental neuroscience to modulate neuronal or behavioral activity, which led this technique be considered neurorehabilitation. Because the cortex and surrounding anatomy have irregular geometries as well inhomogeneous anisotropic properties, mechanism by CES therapeutic effects is poorly understood. Therapeutic of can improved optimizing parameters based on various target brain regions. Approach. In study we...
Ischemic stroke is a major cause of disability among adults worldwide. Despite its prevalence, few effective treatment options exist to alleviate sensory and motor dysfunctions that result from stroke. In the past, rodent models have been primary experimental used develop therapies. However, positive results in these studies failed replicate human clinical trials, highlighting importance nonhuman primate (NHP) as preclinical step. Although there are NHP stroke, extent tissue damage highly...
The functional consequences of ischemic stroke in the remote brain regions are not well characterized. current study sought to determine changes hippocampal oscillatory activity that may underlie cognitive impairment observed following distal middle cerebral artery occlusion (dMCAO) without causing structural damage. Local field potentials were recorded from dorsal hippocampus and cortex urethane-anesthetized rats with multichannel silicon probes during dMCAO reperfusion, or mild ischemia...
Non-human primates (NHPs) are critical for development of translational neural technologies because their neurological and neuroanatomical similarities to humans. Large-scale interfaces in NHPs with multiple modalities stimulation data collection poise us unveil network-scale dynamics both healthy unhealthy systems. We aim develop a large-scale multi-modal interface the purpose studying phenomena including disease, damage, recovery.
Because aberrant network-level functional connectivity underlies a variety of neural disorders, the ability to induce targeted reorganization would be profound development toward therapies for disorders. Brain stimulation has been shown large-scale network-wide changes (FCC), but mapping from induced is unclear. Here, we develop model which jointly considers protocol and cortical network structure accurately predict FCC in response optogenetic non-human primate primary sensorimotor cortex....
While the development of microelectrode arrays has enabled access to disparate regions a cortex for neurorehabilitation, neuroprosthetic and basic neuroscience research, accurate interpretation signals manipulation cortical neurons depend upon anatomical placement electrode in layered cortex. Toward this end, report compares two vivo methods identifying electrodes linear array spaced 100 µm apart based on situ laminar analysis (1) ketamine-xylazine-induced field potential oscillations rat...
Although several studies have shown the feasibility of using optogenetics in non-human primates (NHP), reliable largescale chronic interfaces not yet been reported for such NHP. Here we introduce a setup that permits repeated, daily optogenetic stimulation and large-scale recording from same sites NHP cortex. The combines with transparent artificial dura (AD) high-density micro-electrocorticography (μECoG). To obtain expression across large areas cortex, infused AAV5-CamKIIa-C1V1-EYFP viral...
Optogenetics has been a powerful scientific tool for two decades, yet its integration with non-human primate (NHP) electrophysiology limited due to several technical challenges. These include lack of electrode arrays capable supporting large-scale and long-term optical access, inaccessible viral vector delivery methods transfection large regions cortex, paucity hardware designed patterned cortical illumination, inflexible designs multi-modal experimentation. To address these gaps, we...
The interface between neural prostheses and tissue plays a significant role in the long term performance of these devices. Conducting polymers have been used to modify electrical properties microelectrodes. objective this study was evaluate recording chronic activity microelectrodes that were modified with nanofibers-templated poly (3,4-ethylenedioxythiophene) (PEDOT) nanotubes over seven week periods using impedance spectroscopy signal-to-noise ratio measurements. PEDOT nanotubes-coated...
Brain stimulation has emerged as a novel therapy for ischemic stroke, major cause of brain injury that often results in lifelong disability. Although past works rodents have demonstrated protective effects following few these been replicated humans due to the anatomical differences between rodent and human brains limited understanding stimulation-induced network changes. Therefore, we combined electrophysiology histology study neuroprotective mechanisms electrical cortical stroke non-human...
Optogenetics is a powerful tool that enables millisecond-level control of the activity specific groups neurons. Furthermore, it has great advantage artifact free recordings. These characteristics make this technique ideal for relating brain function to behavior in animals with behavioral capabilities such as non-human primates (NHPs). We recently introduced practical, stable interface optogenetic stimulation and recording large-scale cortical circuits NHPs. Here we present various potentials...