A5024947116- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Face Recognition and Perception
- Decision-Making and Behavioral Economics
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Mental Health Research Topics
- Molecular Communication and Nanonetworks
- Olfactory and Sensory Function Studies
- Biofield Effects and Biophysics
- Motor Control and Adaptation
- Health, Environment, Cognitive Aging
- Cognitive Science and Mapping
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Aesthetic Perception and Analysis
- Stress Responses and Cortisol
- Neurobiology and Insect Physiology Research
- Action Observation and Synchronization
Washington University in St. Louis
2015-2024
National Eye Institute
2008-2015
National Institutes of Health
2008-2013
Max Planck Institute for Biological Cybernetics
2012
Max Planck Society
2012
Brown University
2009
Abstract Behavioral and economic theory dictate that we decide between options based on their values. However, humans animals eagerly seek information about uncertain future rewards, even when this does not provide any objective value. This implies decisions are made by endowing with subjective value integrating it the of extrinsic but mechanism is unknown. Here, show human monkey judgements obey strikingly conserved computational principles during multi-attribute trading off reward. We then...
We understand the world by making saccadic eye movements to various objects. However, it is unclear how a saccade can be aimed at particular object, because two kinds of visual information, what object and where is, are processed separately in dorsal ventral cortical pathways. Here, we provide evidence suggesting that basal ganglia circuit through tail monkey caudate nucleus (CDt) guides such object-directed saccades. First, many CDt neurons responded objects depending on were. Second,...
Anterior cingulate cortex (ACC) is thought to control a wide range of reward, punishment, and uncertainty-related behaviors. However, how it does so unclear. Here, in Pavlovian procedure which monkeys displayed diverse repertoire reward-related, punishment-related, behaviors, we show that many ACC-neurons represent expected value uncertainty valence-specific manner, signaling or predictions about either rewards punishments. Other signal prediction information punishments by displaying...
The ventromedial prefrontal cortex (vmPFC) is thought to be related emotional experience and the processing of stimulus action values. However, little known about how single vmPFC neurons process prediction reception rewards punishments. We recorded from monkey in an experimental situation with alternating blocks, one which were delivered punishments delivered. Many changed their activity between blocks. Importantly, ventral persistently more active appetitive "reward" block, whereas dorsal...
Abstract Humans and other animals often show a strong desire to know the uncertain rewards their future has in store, even when they cannot use this information influence outcome. However, it is unknown how brain predicts opportunities gain motivates information-seeking behavior. Here we that neurons network of interconnected subregions primate anterior cingulate cortex basal ganglia predict moment gaining about rewards. Spontaneous increases prediction signals are followed by gaze shifts...
We investigated the link between neuronal activity in frontal eye field (FEF) and enhancement of visual processing associated with covert spatial attention absence movements. correlated recorded FEF monkeys manually reporting identity a search target to performance accuracy reaction time. Monkeys were cued most probable location cue array containing popout color singleton. Neurons exhibited spatially selective responses for stimulus array. The magnitude related prior presentation was trends...
It has been suggested that the basal forebrain (BF) exerts strong influences on formation of memory and behavior. However, what information is used for memory-behavior unclear. We found a population neurons in medial BF (medial septum diagonal band Broca) macaque monkeys encodes unique combination information: reward uncertainty, expected value, anticipation punishment, unexpected punishment. The results were obtained while expecting (often with uncertainty) rewarding or punishing outcome...
The dorsal raphe nucleus (DRN) is implicated in psychiatric disorders that feature impaired sensitivity to reward amount, impulsivity when facing delays, and risk-seeking confronting uncertainty. However, it has been unclear whether how DRN neurons signal delay, uncertainty during multi-attribute value-based decision-making, where subjects consider these attributes make a choice. We recorded as monkeys chose between offers whose attributes, namely expected uncertainty, varied independently....
Abstract To learn, obtain reward and survive, humans other animals must monitor, approach act on objects that are associated with variable or unknown rewards. However, the neuronal mechanisms mediate behaviours aimed at uncertain poorly understood. Here we demonstrate a set of neurons in an internal-capsule bordering regions primate dorsal striatum, within putamen caudate nucleus, signal uncertainty object–reward associations. Their responses depend presence evolve rapidly as monkeys learn...
The ability to use information about the uncertainty of future outcomes is critical for adaptive behavior in an uncertain world. We show that basal forebrain (BF) contains at least two distinct neural-coding strategies support this capacity. dorsal-lateral BF, including ventral pallidum (VP), reward-sensitive neurons, some which are selectively suppressed by uncertain-reward predictions (U<sup>−</sup>). In contrast, medial BF (mBF) enhanced (U<sup>+</sup>) predictions. a two-alternative...
Primates and other animals must detect novel objects. However, the neuronal mechanisms of novelty detection remain unclear. Prominent theories propose that visual object is either derived from computation recency (how long ago a stimulus was experienced) or form sensory surprise (stimulus unpredictability). Here, we use high-channel electrophysiology in primates to show many primate prefrontal, temporal, subcortical brain areas, intertwined with computations surprise. Also, distinct circuits...