A5021080661- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Molecular Communication and Nanonetworks
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
The University of Texas Health Science Center at Houston
2020-2023
Attention improves perception by enhancing the neural encoding of sensory information. A long-standing hypothesis is that cortical feedback projections carry top-down signals to influence coding. However, this has never been tested establish causal links. We used viral tools label connections from area V4 targeting early visual cortex (area V1). While monkeys performed a visual-spatial attention task, inactivating axonal terminals in V1 without altering local intracortical and feedforward...
Our perception of the environment relies on efficient propagation neural signals across cortical networks. During time course a day, responses fluctuate dramatically as state brain changes to possibly influence how electrical propagate circuits. Despite importance this issue, patterns spiking activity within neuronal circuits in different states remains unknown. Here, we used multielectrode laminar arrays reveal that strongly modulates layers early visual cortex (V1). We optogenetically...
Cortical inactivation represents a key causal manipulation allowing the study of cortical circuits and their impact on behavior. A assumption in studies is that neurons target area become silent while surrounding tissue only negligibly impacted. However, individual are embedded complex local composed excitatory inhibitory cells with connections extending hundreds microns. This raises possibility silencing one part network could induce complex, unpredictable activity changes outside targeted...