A5100631266- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Acute Ischemic Stroke Management
- Autophagy in Disease and Therapy
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Advanced ceramic materials synthesis
- Neurological Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Sulfur Compounds in Biology
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Advanced materials and composites
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
- S100 Proteins and Annexins
- Neuroscience of respiration and sleep
- Dysphagia Assessment and Management
- Circadian rhythm and melatonin
Soochow University
2016-2025
Second Affiliated Hospital of Soochow University
2016-2025
Beijing Jishuitan Hospital
2025
Capital Medical University
2018-2025
Peking University
2012-2025
Nanjing University
2021-2025
Qingdao University
2023-2025
Fudan University
2004-2025
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation α‐synuclein (α‐syn). Ferroptosis, form cell death induced iron accumulation lipid peroxidation, involved in pathogenesis PD. It unknown whether melatonin receptor 1 (MT1) modulates α‐syn ferroptosis Here, we used preformed fibrils (PFFs) to induce PD models vivo vitro. In mice, led increased deposition ferroptosis. MT1 knockout exacerbated these changes...
The present study evaluated autophagy activation in astrocytes and its contribution to astrocyte injury induced by cerebral ischemia hypoxia. Focal was permanent middle artery occlusion (pMCAO) rats. In vitro hypoxia cultured primary the oxygen-glucose deprivation (OGD). Alterations of were with astroglia markers glial fibrillary acidic protein (GFAP). formation autophagosomes examined transmission electron microscopy (TEM). expression autophagy-related proteins immunoblotting. role OGD or...
Sexually dimorphic development of the gonads is controlled by positive and negative regulators produced somatic cells. Many Wnt ligands, including ones that signal via canonical beta-catenin pathway, are expressed in fetal gonads. beta-catenin, a key transcriptional regulator pathway an element cell adhesion complex, essential for various aspects embryogenesis. To study involvement sex determination, we ablated specifically SF1-positive population Although was present both sexes, it...
Neuroinflammation and autophagy dysfunction are closely related to the development of neurodegeneration such as Parkinson's disease (PD). However, role in microglia polarization neuroinflammation is poorly understood. TNF-α, which highly toxic dopaminergic neurons, implicated a major mediator PD. In this study, we found that TNF-α resulted an impairment autophagic flux microglia. Concomitantly, increase M1 marker (iNOS/NO, IL-1β, IL-6) expression reduction M2 (Arginase1, Ym1/2, IL-10) were...
Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen on a rat model unilateral ureteral obstruction. Compared with normal rats, obstructive injury plasma level. Cystathionine-β-synthase, sulfide-producing enzyme, was dramatically reduced obstructed kidney, but another enzyme cystathionine-γ-lyase increased. A donor (sodium sulfide) inhibited renal fibrosis by attenuating production collagen,...
Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis and other cardiovascular diseases. Unfortunately, Hcy-lowering strategies were found to have limited effects in reducing events. The underlying mechanisms remain unclear. Increasing evidence reveals a role inflammation the pathogenesis HHcy. Homocysteine (Hcy) precursor hydrogen sulfide (H2S), which formed via transsulfuration pathway catalyzed by cystathionine β-synthase γ-lyase (CSE) serves as novel modulator...
Carvacrol (CAR), a naturally occurring monoterpenic phenol and food additive, has been shown to have antimicrobials, antitumor, antidepressant-like activities. A previous study demonstrated that CAR the ability protect liver against ischemia/reperfusion injury in rats. In this study, we investigated protective effects of on cerebral middle artery occlusion mouse model. We found (50 mg/kg) significantly reduced infarct volume improved neurological deficits after 75 min ischemia 24 h...
With the rapid development of Cloud computing, more and users deposit their data application on cloud. But computing is hindered by many security problem. has characteristics, e.g. multi-user, virtualization, scalability so on. Because these new traditional technologies can't make fully safe. Therefore, becomes current research focus also this paper's direction <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[1]</sup> . In order to solve problem...
By using two structurally unrelated hydrogen sulfide (H2 S) donors 5-(4-methoxyphenyl) -3H-1, 2-dithiole-3-thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2 S protected blood-brain barrier (BBB) integrity following middle cerebral artery occlusion (MCAO). ICR mice underwent MCAO received at 3 h after reperfusion. Infarction, neurological scores, brain edema, Evans blue (EB) extravasation, tight junction protein expression were examined 48 MCAO. We also ADT BBB by...
Abstract The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease (PD) pathogenesis and underlies the spread α‐Syn pathology. During this process, extracellular can activate microglia neuroinflammation, which plays an important role in PD. However, effect on autophagy is poorly understood. In present study, we reported that inhibited initiation, as indicated by LC3‐II reduction p62 protein elevation BV2 cultured primary microglia. vitro findings were...
Dysfunction of the circadian rhythm is one most common nonmotor symptoms in Parkinson's disease (PD), but molecular role PD unclear. We here showed that inactivation brain and muscle ARNT-like 1 (BMAL1) 1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine (MPTP)-treated mice resulted obvious motor functional deficit, loss dopaminergic neurons (DANs) substantia nigra pars compacta (SNpc), decrease dopamine (DA) transmitter, increased activation microglia astrocytes striatum. Time on rotarod or...
Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Although its pathogenesis remains unclear, a number studies indicate that microglia‐mediated neuroinflammation makes great contribution to PD. Melatonin receptor 1 (MT1) widely expressed in glia cells and neurons substantia nigra (SN). Neuronal MT1 neuroprotective factor, but it largely unknown whether dysfunction microglial involved PD pathogenesis. Here, we found was reduced microglia SN...