A5068531085- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurological Disorders and Treatments
- Olfactory and Sensory Function Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Advanced Chemical Sensor Technologies
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Brain Tumor Detection and Classification
- Medical Imaging and Analysis
- Ultrasound in Clinical Applications
- Acute Ischemic Stroke Management
- Genetic Neurodegenerative Diseases
- Family Caregiving in Mental Illness
- RNA modifications and cancer
- Geriatric Care and Nursing Homes
- EEG and Brain-Computer Interfaces
Hunan University of Science and Technology
2025
Wenzhou Hospital of Traditional Chinese Medicine
2024
Tianjin University
2020-2024
Tianjin Huanhu Hospital
2015-2024
Nankai University
2019-2024
Anhui University of Technology
2023-2024
Suzhou Municipal Hospital
2024
Nanjing Medical University
2024
Boai Hospital of Zhongshan
2024
Tianjin Medical University
2022-2024
To evaluate caregiver burden and factors that influence this among caregivers patients with Alzheimer's disease in China.Long-term care can reduce the quality of life for result both mental physical exhaustion. However, little is known about associated China.The study had a quantitative cross-sectional design.A total 309 their were included study. The patients' cognitive, psychological functional status caregivers' burden, sleep state evaluated. Descriptive analyses, single-factor regression...
Background/Aims . Low serum folate levels can alter inflammatory reactions. Both phenomena have been linked to Alzheimer’s disease (AD), but the effect of folic acid on AD itself is unclear. We quantified supplementation’s inflammation and cognitive function in patients with over course 6 months. Methods Patients newly diagnosed (age > 60 years;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn...
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
Hippocampal morphological change is one of the main hallmarks Alzheimer's disease (AD). However, whether hippocampal radiomic features are robust as predictors progression from mild cognitive impairment (MCI) to AD dementia and these provide any neurobiological foundation remains unclear. The primary aim this study was verify can serve magnetic resonance imaging (MRI) markers for AD. Multivariate classifier-based support vector machine (SVM) analysis provided individual-level predictions...
Abstract Precision medicine for Alzheimer's disease (AD) necessitates the development of personalized, reproducible, and neuroscientifically interpretable biomarkers, yet despite remarkable advances, few such biomarkers are available. Also, a comprehensive evaluation neurobiological basis generalizability end‐to‐end machine learning system should be given highest priority. For this reason, deep model (3D attention network, 3DAN) that can simultaneously capture candidate imaging with an...
ABSTRACT Background: Very few recent studies are available that compare caregiver burden, sleep quality, and stress in caregivers of different types dementia. We aimed to investigate patients with frontotemporal lobar degeneration dementia Lewy bodies, as compared Alzheimer's disease. Methods: This study was carried out from March 2011 January 2014. In total, 492 dyads patient (frontotemporal degeneration, n = 131; 36; disease, 325) participated this study. respect the Neuropsychiatric...
To investigate the effects of resveratrol on cognitive impairment in streptozotocin (STZ)-induced diabetic rats and to explore mechanisms that phenomenon.Sixty healthy male Sprague Dawley were randomly divided into four groups: normal control group (Con group, n = 15), Res (normal treated with resveratrol, diabetes mellitus (DM 15) DM + (diabetic treat 15). Streptozotocin (STZ) was injected intraperitoneally establish model. One week after model induction, animals received once a day for...
Abstract Previous genome-wide association studies have identified dozens of susceptibility loci for sporadic Alzheimer’s disease, but few these been validated in longitudinal cohorts. Establishing predictive models disease based on novel variants is clinically important verifying whether they pathological functions and provide a useful tool screening risk. In the current study, we performed two-stage study 3913 patients with 7593 controls four (rs3777215, rs6859823, rs234434, rs2255835;...
Abstract Alzheimer's disease (AD) is associated with disruptions in brain activity and networks. However, there substantial inconsistency among studies that have investigated functional alterations AD; such contradictions hindered efforts to elucidate the core mechanisms. In this study, we aim comprehensively characterize AD‐associated using one of world's largest resting‐state MRI (fMRI) biobank for disorder. The includes fMRI data from six neuroimaging centers, a total 252 AD patients, 221...
Alzheimer's disease (AD) is a neurodegenerative associated with widespread disruptions in intrinsic local specialization and global integration the functional system of brain. These changes may further disrupt signal (GS) distribution, which might represent relative contribution to activity magnetic resonance imaging (fMRI).
Background: There is a growing focus on nutritional therapy for Alzheimer's disease (AD), and controversy exists regarding the association between AD homocysteine (Hcy), vitamin B12, folate levels. Objective: The present study evaluated combined levels of Hcy, folate. Methods: This case-control consisted 115 patients with matched controls. Serum B12 were measured using an automated immunoassay analyzer. Plasma Hcy was high-performance liquid chromatography. analyzed binary logistic...
The prevalence and factors associated with delays in help seeking for people dementia China are unknown.Within 1,010 consecutively registered participants the Clinical Pathway Alzheimer's Disease (CPAD) study (NCT01779310), 576 persons (PWDs) their informants reported estimated time from symptom onset to first medical visit diagnosis. Univariate analysis of general linear model was used examine potential delayed diagnosis seeking.The median duration noticeable or treatment 1.77 years....
Abstract Parkinson’s disease (PD) is a long term disorder affects the central nervous system and we aim to determine relative efficacy of current available drugs used in PD. Firstly, performed systematic review literature eligible studies were retrieved from online databases, relevant data extracted. Efficacy these medications was assessed by different Unified Disease Rating Scales (UPDRS). Mean difference (MD) odds ratio (OR) produced pairwise or network meta-analysis (NMA). Finally,...
Non-high density lipoprotein cholesterol (HDL-C) could be a good predictor of vascular disease outcomes. To evaluate the association between serum non-HDL-C and cognitive impairment in patients with acute ischemic stroke.A total 725 hospitalized stroke were enrolled. They received conventional treatment. Cognitive function was assessed on 3rd day after admission using mini-mental state examination (MMSE), Montreal Assessment (MoCA), Activity Daily Living Scale (ADL), Neuropsychiatric...
Abstract Background The relationship between the apolipoprotein E ( APOE )- ε4 allele, triglyceride (TG) level, and cholesterol level an increased risk of developing Alzheimer’s disease (AD) has been well established, but their with behavioral-variant frontotemporal dementia (bvFTD) is not well-known. Methodology levels TGs, total (TC), low-density lipoprotein (LDL), high-density were measured in bvFTD AD patients normal controls (NCs). DNA was extracted, genotyped. Results APOE-ε4 allele...
<b><i>Background:</i></b> Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two common forms of primary neurodegenerative dementia. Mutations in 3 genes <i>(PSEN1, PSEN2,</i> <i>APP)</i> have been identified patients with early-onset AD. <b><i>Methods:</i></b> We performed gene sequencing <i>PSEN1, <i>APP</i> 61 AD 35 FTD Chinese patients. Amyloid load using...
Background:Alzheimer's disease (AD) is the most common cause of dementia in older individuals, and amnestic mild cognitive impairment (aMCI) currently considered prodromal stage AD. The hippocampus fornix interact functionally structurally, with being major efferent white matter tract from hippocampus. Objective:The main aim this study was to examine impairments present subjects AD or aMCI relationship these microstructure functional connectivity (FC) gray volume Methods:Forty-four AD, 34...