A5056412091- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Cholinesterase and Neurodegenerative Diseases
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disorders and Treatments
- Epigenetics and DNA Methylation
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Cerebrovascular and genetic disorders
- Nuclear Receptors and Signaling
- Spinal Dysraphism and Malformations
- Neurosurgical Procedures and Complications
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- 14-3-3 protein interactions
- Cardiac Imaging and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease Mechanisms and Treatments
Affiliated Hospital of Hebei University
2024-2025
Capital Medical University
2016-2025
Beijing Geriatric Hospital
2014-2025
Ministry of Education of the People's Republic of China
2013-2025
Chinese Institute for Brain Research
2015-2025
Beijing Chao-Yang Hospital
2012-2024
Daqing Oilfield General Hospital
2024
Hebei Medical University
2024
Beijing Chaoyang Emergency Medical Center
2017-2024
Affiliated Hospital of Chengde Medical College
2024
China has a large population of older people, but not yet undertaken comprehensive study on the prevalence, risk factors, and management both dementia mild cognitive impairment (MCI).For this national cross-sectional study, 46 011 adults aged 60 years or were recruited between March 10, 2015, Dec 26, 2018, using multistage, stratified, cluster-sampling method, which considered geographical region, degree urbanisation, economic development status, sex age distribution. 96 sites randomly...
The socioeconomic costs of Alzheimer's disease (AD) in China and its impact on global economic burden remain uncertain.We collected data from 3098 patients with AD 81 representative centers across estimated for individual patient total 2015. Based this data, we re-estimated the worldwide AD.The annual cost per was US $19,144.36, were $167.74 billion are predicted to reach $507.49 2030 $1.89 trillion 2050. our results, estimates dementia $957.56 2015, will be $2.54 2030, $9.12 2050, much more...
Abstract Introduction Neuronal‐derived exosomal Aβ42, T‐tau, and P‐T181‐tau have been demonstrated to be biomarkers of Alzheimer's disease (AD). However, no study has assessed the association between exosomes CSF. Methods This was a multicenter with two‐stage design. The subjects included 28 AD patients, 25 aMCI 29 controls in discovery stage; results which were confirmed validation stage (73 AD, 71 aMCI, 72 controls). Results concentrations group higher than those control groups (all P <...
Biomarker changes that occur in the period between normal cognition and diagnosis of sporadic Alzheimer's disease have not been extensively investigated longitudinal studies.
Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.Using a multistage cluster sampling design, total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, dementia. MCI was further categorized by imaging into caused prodromal Alzheimer's disease (MCI-A), resulting from cerebrovascular (MCI-CVD), vascular risk factors (MCI-VRF), other diseases (MCI-O).The prevalences overall MCI-A,...
Neuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers Alzheimer's disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in can aid diagnosis AD.The were collected by ultracentrifuge. Protein samples extracted exosomes. Cerebrospinal fluid levels amyloid β (Aβ)42 phosphorylated tau (P-tau)181 measured diagnostic purposes. A pilot (controls, 20; AD, 20)...
Abstract Introduction The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the genetic features of FAD pedigrees and without mutations. Methods In total, 1330 (AD) or mild cognitive impairment 404 were enrolled from Familial Disease Network. mutations APOE frequencies determined. Results 13.12% carried missense mutations, 3.71% synonymous/untranslated region variants, 83.17% did not carry Eleven first identified....
Purpose: Enlarged perivascular spaces (EPVS) have been widely considered as a feature of cerebral small vessel disease (cSVD) but the pathogenesis EPVS remains unclear. Compromised blood-brain barrier (BBB) integrity may play role since previous studies shown that BBB breakdown is critical contributor to other cSVD markers. This study aimed investigate association in centrum semiovale (CSO) and basal ganglia (BG) with permeability. Patients methods: Consecutive participants free symptomatic...
Abstract Previous genome-wide association studies have identified dozens of susceptibility loci for sporadic Alzheimer’s disease, but few these been validated in longitudinal cohorts. Establishing predictive models disease based on novel variants is clinically important verifying whether they pathological functions and provide a useful tool screening risk. In the current study, we performed two-stage study 3913 patients with 7593 controls four (rs3777215, rs6859823, rs234434, rs2255835;...
Current and future incidence prevalence estimates of dementia are essential for public health planning.The objective was to establish prediction model estimate the in Chinese worldwide population from 2020 2050.A model-based method used project 2050 China, which required incidence, mortality rate individual without dementia, relative risk death. Furthermore, we detected impact intervention on projection using a simulation method. We applied same other projections worldwide.In 2020, predicted...
Several studies have demonstrated that compromised blood-brain barrier (BBB) integrity may play a pivotal role in the pathogenesis of individual cerebral small vessel disease (cSVD) markers, but association between BBB permeability and total magnetic resonance imaging (MRI) cSVD burden remains unclear. This study aimed to investigate relationship MRI burden. Consecutive participants without symptomatic stroke history presented for physical examination were enrolled this cross-sectional...
Abstract Introduction The status of dementia diagnosis and treatment neurology outpatients in general hospitals China remains unclear. Methods From at 36 randomly selected hospitals, we first collected baseline data concerning the number doctors, memory clinics, patients diagnosed with dementia. In stage 2, intervened based on drawbacks discovered 1, implementing a initiative program. 3, reinvestigated to determine effects intervention. Results After intervention, all had established clinics...
Abstract Alzheimer's disease (AD) is the leading cause of dementia, characterized by neuropathological features such as amyloid-β (Aβ) plaques, neurofibrillary tau tangles, and neurodegeneration. Immunotherapy offers a promising potentially disease-modifying treatment for AD. We review recent advances in AD immunotherapy, specifically focusing on Aβ, tau, neuroinflammation-targeted approaches, gain insights from randomized controlled trials to propose directions.
Background Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors BG-EPVS in patients acute lacunar stroke. Methods We prospectively identified stroke (diameter on DWI ≤ 20mm) from Jan 2011 May 2015. Patients were T2 weighted MRI. Age (± 1 year) sex matched controls also recruited same population (two one case)....
Objectives Recent studies reported that 24-hour ambulatory blood pressure variability (ABPV) was associated with lacunar infarction and white matter hyperintensities (WMH). However, the relationship between ABPV enlarged perivascular spaces (EPVS) has not been investigated. Thus, our study aimed to investigate whether is EPVS by monitoring (ABPM). Design We conducted this as a cross-sectional study. Settings The based on patients who presented for physical examinations in hospital from May...
Abstract Aims This study investigated the relationship between plasma Wnt2b levels and Alzheimer's disease (AD), explored effect of on mitochondrial dysfunction in AD. Methods Healthy AD subjects, transgenic mice, vitro models were used to investigate roles abnormalities canonical Wnt signaling mitochondria RT‐qPCR, immunoblotting, immunofluorescence analysis performed assay signaling. Mitochondrial structure was analyzed by electron microscopy. Flow cytometry examine intracellular calcium...
Transgenic mouse models are powerful tools in exploring the mechanisms of AD. Most current transgenic AD mimic memory impairment and main pathologic features, among which formation beta-amyloid (Aβ) plaques is considered a dominant event. Recently, Aβ oligomers have been identified as more neurotoxic than plaques. However, no ideal model directly support species due to puzzling effects amyloid widely-used models. Here, we constructed single-mutant (Tg) harboring PS1V97L mutation used Non-Tg...
Lacunae, brain atrophy, white matter hyperintensity, enlarged perivascular space and microbleed are magnetic resonance imaging (MRI) markers of cerebral small-vessel disease (cSVD). Studies have reported that higher blood pressure variability (BPV) predicted cardiovascular risk in hypertensive patients; however, the association between BPV total MRI burden cSVD has not been investigated. In this study, we aimed to explore relationship burden.We prospectively recruited patients who attended...