A5100412788- Migraine and Headache Studies
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Dementia and Cognitive Impairment Research
- Hereditary Neurological Disorders
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Hair Growth and Disorders
- Ion Channels and Receptors
- Congenital heart defects research
- Cerebrovascular and Carotid Artery Diseases
- Polymer composites and self-healing
- Alzheimer's disease research and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Robotics and Automated Systems
- Vestibular and auditory disorders
- Digital Imaging for Blood Diseases
- Organoselenium and organotellurium chemistry
- Autophagy in Disease and Therapy
- Electrical Fault Detection and Protection
- Wnt/β-catenin signaling in development and cancer
- Vanadium and Halogenation Chemistry
Washington University in St. Louis
2019-2024
Hebei Medical University
2024
South China Agricultural University
2024
Beihang University
2024
Affiliated Hospital of Southwest Medical University
2024
Southwest Medical University
2024
Jiangsu University of Technology
2024
First Affiliated Hospital of Sichuan Medical University
2024
Daqing Oilfield General Hospital
2024
82th Hospital of Pla
2023
Biomarker changes that occur in the period between normal cognition and diagnosis of sporadic Alzheimer's disease have not been extensively investigated longitudinal studies.
Abstract Objective To identify an optimal lifestyle profile to protect against memory loss in older individuals. Design Population based, prospective cohort study. Setting Participants from areas representative of the north, south, and west China. Individuals aged 60 years or who had normal cognition underwent apolipoprotein E (APOE) genotyping at baseline 2009. Main outcome measures were followed up until death, discontinuation, 26 December 2019. Six healthy factors assessed: a diet...
Purpose Butyrate, a short-chain fatty acid derived from dietary fiber, inhibits proliferation and induces cell death in colorectal cancer cells. However, clinical trials have shown mixed results regarding the anti-tumor activities of butyrate. We previously that sodium butyrate increases endoplasmic reticulum stress by altering intracellular calcium levels, well-known autophagy trigger. Here, we investigated whether butyrate-induced mediated autophagy, there was crosstalk between apoptotic...
Mesenchymal stem cell (MSCs)-derived small Extracellular Vesicles (sEVs) are considered as a new cell-free therapy for pain caused by nerve injury, but whether human placental mesenchymal cell-derived sEVs relieve in sciatic injury and its possible mechanism still unclear. In this study, we investigated the roles of hPMSCs-derived related mechanisms neuropathic pain.The spared (SNI) mouse model was employed. Intrathecal injection or miR-26a-5p agomir performed on seventh day modeling, to...
A large body of animal and human studies indicates that blocking peripheral calcitonin gene-related peptide (CGRP) pituitary adenylate cyclase-activating polypeptide (PACAP) signaling pathways may prevent migraine episodes reduce headache frequency. To investigate whether recurring alter the strength CGRP PACAP in trigeminal ganglion (TG) neurons, we compared number TG neurons respond to (CGRP-R PACAP-R, respectively) under normal chronic migraine-like conditions. In a mouse model migraine,...
Abstract Although TWIK-related spinal cord K + (TRESK) channel is expressed in all primary afferent neurons trigeminal ganglia (TG) and dorsal root (DRG), whether TRESK activity regulates pain processing still not established. Dominant-negative mutations are associated with migraine but other types of humans, suggesting that genetic dysfunction preferentially affects the generation pain, especially headache. Using global knock-out mice as a model system, we found loss TG selectively...
Abstract Migraine, especially chronic migraine, is highly debilitating and still lacks effective treatment. The persistent headache arises from activation sensitization of primary afferent neurons in the trigeminovascular pathway, but underlying mechanisms remain incompletely understood. Animal studies indicate that signalling through chemokine C-C motif ligand 2 (CCL2) receptor (CCR2) mediates development pain after tissue or nerve injury. Some migraine patients had elevated CCL2 levels CSF...
Abstract Headache disorders are highly prevalent and debilitating, with limited treatment options. Previous studies indicate that many proinflammatory immune cells contribute to headache pathophysiology. Given the well-recognized role of regulatory T (Treg) in maintaining homeostasis, we hypothesized enhancing Treg function may be effective treat multiple disorders. In a mouse model chronic migraine, observed repeated nitroglycerin (NTG, reliable trigger migraine patients) administration...
Medication overuse headache (MOH) is the most common secondary disorder, resulting from chronic and excessive use of medication to treat headaches, for example, sumatriptan. In a recent study, we have shown that peripheral C-C motif ligand 2 (CCL2), chemokine receptor (CCR2) calcitonin-gene-related peptide (CGRP) signaling pathways interact with each other play critical roles in development migraine-related behavioral cellular sensitization. present investigated whether CCL2-CCR2 CGRP role...
Low-dose interleukin-2 (LD-IL-2) treatment has been shown to effectively reverse chronic migraine-related behaviors and the sensitization of trigeminal ganglion (TG) neurons through expansion activation peripheral regulatory T cells (Tregs) in mice. In this study, we investigated molecular mechanisms underlying effects LD-IL-2 Treg cells. increases production cytokines interleukin-10 (IL-10) transforming growth factor beta-1 (TGFβ1) cells, especially suggesting that they may mediate...
Objective Despite the high prevalence, mild traumatic brain injury (mTBI)‐induced chronic headache and cognitive deficits are poorly understood lack effective treatments. Low‐dose interleukin‐2 (LD‐IL‐2) treatment soon after mTBI or overexpressing IL‐2 in astrocytes prior to protects mice from developing post‐traumatic (PTH)‐related behaviors decline. The present study addresses a clinically relevant knowledge gap: whether LD‐IL‐2 long initial is still for PTH deficits. Methods was induced...
Abstract A copper‐catalyzed decarboxylative alkylselenation of propiolic acids with Se powder and epoxides leading to alkynyl selenides is developed. This protocol not only provides an approach obtain the formation double C−Se bonds, but also expands applicability carboxylic acid. magnified image
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffective neutral deaggregatorsXikui Jiang, Guozhen Ji, and Jintao ZhangCite this: Langmuir 1994, 10, 1, 122–125Publication Date (Print):January 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/la00013a017https://doi.org/10.1021/la00013a017research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the...
Nerve injury-induced mechanical hyper-sensitivity, in particular stroking-induced dynamic allodynia, is highly debilitating and difficult to treat. Previous studies indicate that the immunosuppressive regulatory T (Treg) cells modulate magnitude of punctate allodynia resulting from sciatic nerve injury. However, whether enhancing Treg-mediated suppression attenuates not known. In present study, we addressed this knowledge gap by treating mice with low-dose interleukin-2 (ld-IL2) injections...
Background Intracranial aneurysm with endovascular treatment needs to be followed-up a proper imaging method. Purpose To evaluate the performance of magnetic resonance angiography (MRA) zero echo time at 1.5-T in assessing intracranial remnant and in-stent lumen as compared time-of-flight MRA, digital subtraction gold standard. Material Methods A total 46 patients (17 men; mean age = 56.6±13.7 years) 54 aneurysms who underwent coil embolization or without stent were enrolled this study. The...
Most of the current SLAM methods are for experiments in static environments, but most practical application scenarios dynamic which increases fitting error feature points and reduces accuracy position estimation. In order to eliminate this error, paper proposes a YRG-SLAM method based on RealSense D435i camera parameters environments. method, YOLOv5s target detection thread is added original ORB-SLAM3 algorithm structure, placed GPU, point rejection module tracking thread. After acquiring...
Abstract Although dominant-negative mutations of TRESK background K + channel have been reported in migraine patients, whether activity controls the generation trigeminal pain, especially headache, is not established. We found that loss all ganglia (TG) neurons preferentially increased intrinsic excitability small-diameter TG nociceptors express neuropeptide CGRP or TRPM8 channels. Surprisingly, number expressing TRPV1 In dorsal root neurons, neither persistent outward current nor was...
Proliferative Diabetic Retinopathy (PDR) is a seri-ous retinal disease threatening diabetic patients. Intense neovascularization in the image most important clinical symptom of PDR, leading to visual distortion if not controlled. Accurate and timely detection from images allows patients receive adequate treatment avoid further vision loss. In this work, we propose automatic segmentation model based on im-proved Pyramid Scene Parsing Network (PSP-Net). To improve accuracy model, introduce...
Mutations in the hairless (Hr) gene both mice and humans have been implicated development of congenital atrichia, but role Hr skin hair follicle (HF) biology remains unknown. Here, we established transgenic (TG) overexpressing mutant to investigate its specific HF. Three lines were successfully constructed, two them (TG3 TG8) displayed a pattern loss regrowth with alternation expression HR protein. The inhibited endogenous individuals, which led alopecia. Interestingly, regrew increase...
Objective To explore the feasibility and advantages of early open-heart radical operation on infants children with Tetralogy Fallot(TOF) in different ages to analyze its perioperative outcomes. Methods The clinical data 390 TOF were analyzed, who underwent extracorporeal circulation surgery from January 2007 2014 at Department Cardiovascular Surgery, Third Affiliated Hospital Zhengzhou University.The operative age ranged 3 months 14 years(mean years). There 172 infants(<1 year old)and...