A5100699691- Heavy metals in environment
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cholinesterase and Neurodegenerative Diseases
- Mycorrhizal Fungi and Plant Interactions
- Cancer, Hypoxia, and Metabolism
- Phytoestrogen effects and research
- Alzheimer's disease research and treatments
- Chromium effects and bioremediation
- Phytochemicals and Antioxidant Activities
- Metabolism, Diabetes, and Cancer
- Ruminant Nutrition and Digestive Physiology
- Bioactive Compounds in Plants
- Fungal Biology and Applications
- Calcium signaling and nucleotide metabolism
- Natural product bioactivities and synthesis
- Plant Stress Responses and Tolerance
- Computational Drug Discovery Methods
- Microbial Metabolites in Food Biotechnology
- Cancer-related molecular mechanisms research
- Sphingolipid Metabolism and Signaling
- Legume Nitrogen Fixing Symbiosis
- MicroRNA in disease regulation
- Immune cells in cancer
Southern Medical University
2012-2025
Henan University of Science and Technology
2024-2025
State Ethnic Affairs Commission
2024
Guizhou Minzu University
2024
Yale Cancer Center
2020
Yale University
2020
John Brown University
2019
Zhujiang Hospital
2016
Institute of Botany
2012
Chinese PLA General Hospital
2011
Alzheimer9s disease (AD) is a progressive and irreversible neurodegenerative disorder. Familial AD (FAD) mutations in presenilins have been linked to calcium (Ca<sup>2+</sup>) signaling abnormalities. To explain these results, we previously proposed that function as endoplasmic reticulum (ER) passive Ca<sup>2+</sup> leak channels. directly investigate the role of neuronal ER homeostasis, here performed series imaging experiments with primary cultures from conditional presenilin...
We and others have recently shown that soyasaponins abundant in soybeans can decrease inflammation by suppressing the nuclear factor kappa B (NF-kB)-mediated inflammation. However, exact molecular mechanisms which inhibit NF-kB pathway not been established. In this study macrophages, (A1, A2 I) inhibited lipopolysaccharide (LPS)-induced release of inflammatory marker prostaglandin E2 (PGE2) to a similar extent as inhibitor (BAY117082). Soyasaponins also suppressed LPS-induced expression...
Purpose Butyrate, a short-chain fatty acid derived from dietary fiber, inhibits proliferation and induces cell death in colorectal cancer cells. However, clinical trials have shown mixed results regarding the anti-tumor activities of butyrate. We previously that sodium butyrate increases endoplasmic reticulum stress by altering intracellular calcium levels, well-known autophagy trigger. Here, we investigated whether butyrate-induced mediated autophagy, there was crosstalk between apoptotic...
Colorectal cancer (CRC) is one of the most common malignancies, and effective treatment prevention methods are lacking. Sodium butyrate (NaB) a short-chain fatty acid produced by intestinal microbial fermentation dietary fiber. It has been shown to be in inhibiting CRC, but mechanism not known.Human normal epithelial cell line FHT colorectal tumor HCT-116 were treated with NaB alone or combination different programmed death inhibitors. Cell activity was then assessed MTT assays PI staining;...
Lots of active substances are hydrophobic materials at ambient and body temperatures, decreasing their bioavailability posing great challenges to successful incorporation into medication functional foods. The goal this research was develop a nanoemulsion delivery system containing crystalline bioactive component (nobiletin) improve the anti-inflammatory activity. Nobiletin incorporated oily phase, nanoemulsions were fabricated using high-speed high-pressure homogenization. Particle size,...
Cadmium contamination can lead to a decrease in crop yield and quality. However, Cd-tolerant rice improve resistance genes, tolerance heavy metals, protect plants from oxidative damage. In this study, Japonica rice: Chunyou 987 Indica Chuanzhong you 3607 were used reveal the molecular response mechanism of under cadmium concentration 3 mg/kg through comparative experiments combined with physiology proteomics. The results showed that compared indica rice, japonica more robust Cd stress...
Background Inflammatory bowel disease (IBD), encompassing Crohn's (CD) and ulcerative colitis (UC), can seriously impact patients' quality of life. Sodium butyrate (NaB), a product dietary fiber fermentation, has been shown to alleviate IBD symptoms. Some studies have that it is related ferroptosis. However, the precise mechanism linking NaB, IBD, ferroptosis not clear.
Scope Obesity is linked to a chronic low‐grade inflammatory state that contributes the development of obesity‐associated metabolic disorders. The anti‐inflammatory activities and mechanisms soyasaponin monomers (A 1 , A 2 I) have been recently demonstrated in cell models. However, their potential vivo abilities reduce inflammation alleviate disorders obese status remain unclear. Methods results High fat diet (HFD)‐fed male C57BL/6J mice are intervened by aspirin (0.1 mg kg –1 body weight) or...
Arbuscular mycorrhizal fungi (AMF) and plant growth-promoting bacteria enhance tolerance to abiotic stress promote growth in contaminated soil. However, the interaction mechanism between rhizosphere microbial communities under chromium (Cr) remains unclear. This study conducted a greenhouse pot experiment metagenomics analysis reveal comprehensive effects of AMF (Rhizophagus intraradices) nitrogen-N metabolizing promoters on Iris tectorum. The results showed that significantly increased...
The SOCE (store-operated Ca2+ entry) pathway plays a key role in both normal cells and cancerous cells. However, its molecular mechanism remains long-lasting puzzle of signalling. In this paper, we provide evidence that butyric acid, dietary fibre-derived short-chain fatty induces apoptosis colon cancer via signalling networks. We found sodium butyrate (NaB) release from endoplasmic reticulum, which turn causes extracellular influx HCT-116 are important, because the addition chelators, EGTA...
Background
We and others recently showed that soyasaponin Bb (SSBb ) inhibited lipopolysaccharide (LPS)-induced inflammation in macrophages. Since the recruitment of toll-like receptor 4 (TLR4) into lipid rafts is vital for LPS-initiated signaling, we investigated whether this process would be modulated by SSBb .By using sucrose gradient ultracentrifuge, found pretreatment macrophages with LPS-induced recruitments TLR4, myeloid differentiation primary response protein 88 (MyD88) Toll/IL-1...
In this study, we examined the effect of xylooligosaccharide (XOS) supplementation on growth performance, carcass characteristics, and meat quality Hu lambs. total, 60 lambs (two months old weighing 17.32 ± 0.81 kg) were randomly assigned to four treatment groups, each with three replicates five per replicate. The fed basal diets supplemented 0, 1.5, 3, or 4.5 g/kg XOSs in a diet for days, groups designated XOS0%, XOS1.5%, XOS3%, XOS4.5%, respectively. results revealed, compared theXOS0%...
Abstract. During the reproductive process in female mammals, approximately 99 % of follicles involved egg development undergo atresia and are not utilised. The primary cause follicular is granulosa cell (GC) apoptosis. MicroRNAs (miRNAs) play an important regulatory role atresia. It has been widely confirmed that miR-383 regulation GC proliferation, apoptosis, steroid hormone secretion; however, its effect on sheep ovarian remains unknown. In this study, we examined ovine proliferation We...
Abstract Objectives: Sphingosine kinase (SphK), which is regulated by hypoxia, catalyses phosphorylation of sphingosine to produce sphingosine‐1‐phosphate, stimulates invasiveness gliomas. However, whether SphK involved in proliferation glioma cells under hypoxic conditions not clearly understood. In this study, we have investigated the role hypoxia. Materials and methods: Effects small interfering RNA (siRNA) on SphKs, SKI (inhibitor SphK) U0126 ERK) hypoxia were studied using CCK‐8 assay...