A5009094807- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Organoselenium and organotellurium chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Synthesis and Reactions
- Conducting polymers and applications
- Oxidative Organic Chemistry Reactions
- Organic and Inorganic Chemical Reactions
- Perovskite Materials and Applications
- Vanadium and Halogenation Chemistry
- Organic Electronics and Photovoltaics
Wenzhou Medical University
2019-2024
Wenzhou University
2021
State Council of the People's Republic of China
2021
Herein, we describe the first example of copper-catalyzed oxidative thioamination maleimides with secondary amines and Bunte salts achievement C–N C–S bonds in a single flask. The protocol showcases prominently broad substrate scope is also efficient for late-stage modification an array pharmaceuticals. Preliminary mechanistic investigation indicates amination to form reactive enaminone subsequent intermolecular alkenyl C–H thiolation.
The first example of copper-catalyzed four-component coupling reaction aryl iodides, Se powder, secondary amines, and maleimides is developed. This provides an efficient concise route to access aminoarylselenated via double C–Se bonds C–N bond formation. appealing features this transformation are the use powder as a selenating reagent, green catalytic system, wide range substrate scope, late-stage selenation bioactive compounds.
Three-component amino- and carbotrideuteromethylthiolation of alkenes in water.
The first copper-catalyzed oxidative aminophosphorothiolation of maleimides with secondary alkylamines and diethylphosphorodithioate has been established.
An unprecedented copper-catalyzed oxidative aminohalogenation of electron-deficient maleimides with secondary amines and NXS (X = Cl, Br, I) was developed, in which the N-X bonds generated situ were used as difunctionalized reagents. The distinctive features this multicomponent reaction include a simple green catalytic system, spectral substrate range, late-stage modification drug molecules. Most importantly, umpolung radical cascade strategy exploits formation N-iodoamines that enable...
Abstract A copper‐catalyzed oxidative carboamination of maleimides with alkyl amines and α‐bromo carboxylates is described. These multicomponent reactions show good functional group compatibility are suitable for the late‐stage modification a series neuroprotective agents, providing direct path library synthesis 3‐carbo‐4‐amino maleimides. The initial amination to form enamines intermediate, followed by radical alkylation carboxylate compounds, triggers relayed catalytic reaction achieve...
Abstract A copper‐catalyzed decarboxylative alkylselenation of propiolic acids with Se powder and epoxides leading to alkynyl selenides is developed. This protocol not only provides an approach obtain the formation double C−Se bonds, but also expands applicability carboxylic acid. magnified image
The nucleophilic substitution of organohalides with alkylamines is one the most heralded reactions in synthetic chemistry. However, resulting halide anions are often wasted routine workup experiments and not fully utilized. Herein, we report a halogen recycling strategy for radical aminohalogenation maleimides XCH 2 CH X (X = Cl, Br) excellent functional group compatibility. strategy's generality demonstrated by 38 aminohalogenated products, twofold aminochlorination, late‐stage...
The methylthio group plays a significant role in antitumor bioactive molecules, candidate drugs and natural products. Deuteration modification of drugs, which could prolong the half‐life, reduce toxicity, enhance targeting, has become an important strategy development discovery innovative drugs. Combining unique properties with deuteration effect, rapid introduction trideuteromethylthiol groups into small organic molecules is essential for advancing research deuterated With new...