A5003628502- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Diagnosis and Treatment
- Mass Spectrometry Techniques and Applications
- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- Advanced Proteomics Techniques and Applications
- Glutathione Transferases and Polymorphisms
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Pleural and Pulmonary Diseases
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Extracellular vesicles in disease
- Multiple and Secondary Primary Cancers
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
Capital Medical University
2018-2025
National Clinical Research Center for Digestive Diseases
2021-2025
Nanchang University
2015-2024
Second Affiliated Hospital of Nanchang University
2015-2024
Karlsruhe Institute of Technology
2024
Guangxi Medical University
2004-2023
Chinese Institute for Brain Research
2018-2023
Ministry of Education of the People's Republic of China
2018-2023
Beijing Geriatric Hospital
2018-2023
Guangxi Normal University
2004-2023
Abstract Introduction Neuronal‐derived exosomal Aβ42, T‐tau, and P‐T181‐tau have been demonstrated to be biomarkers of Alzheimer's disease (AD). However, no study has assessed the association between exosomes CSF. Methods This was a multicenter with two‐stage design. The subjects included 28 AD patients, 25 aMCI 29 controls in discovery stage; results which were confirmed validation stage (73 AD, 71 aMCI, 72 controls). Results concentrations group higher than those control groups (all P <...
Exosomes are an emerging candidate for biomarkers of Alzheimer's disease (AD). This study investigated whether exosomal synaptic proteins can predict AD at the asymptomatic stage.We conducted a two-stage-sectional (discovery stage: AD, 28; amnestic mild cognitive impairment [aMCI], 25; controls, 29; validation 73; aMCI, 71; 72), including preclinical (160) and controls (160), confirmation in familial (mutation carriers: 59; non-mutation 62).The concentrations growth associated protein 43...
Breast cancer (BC) is a common cause of morbidity and mortality, particularly in women. Moreover, the discovery diagnostic biomarkers for early BC remains challenging task. Previously, we [Jasbi et al. J. Chromatogr. B. 2019, 1105, 26−37] demonstrated targeted metabolic profiling approach capable identifying metabolite marker candidates that could enable highly sensitive specific detection BC. However, coverage this method was limited exhibited suboptimal classification (EBC). To expand...
Neuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers Alzheimer's disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in can aid diagnosis AD.The were collected by ultracentrifuge. Protein samples extracted exosomes. Cerebrospinal fluid levels amyloid β (Aβ)42 phosphorylated tau (P-tau)181 measured diagnostic purposes. A pilot (controls, 20; AD, 20)...
Targeted mass spectrometry (MS) is an important measurement approach in metabolomics with strong analytical performance, given its specificity, sensitivity, and quantitative capacity. However, traditional targeted-MS relies heavily on chemical standards for the development of various detection panels; thus, metabolite coverage often limited to those well-known commercially available compounds. To address this fundamental gap, we previously developed a novel [H. Gu et al. Anal. Chem. 2015,...
Abstract Background The identification of pathogenic mutations in Alzheimer’s disease (AD) causal genes led to a better understanding the pathobiology AD. Familial (FAD) is known be associated with APP, PSEN1, and PSEN2 involved Aβ production; however, these genetic defects occur only about 10–20% FAD cases, more new mechanism causing remain largely obscure. Methods We performed exome sequencing on family members pedigree identified gene variant ZDHHC21 p.T209S. A T209S/T209S knock-in mouse...
A straight-forward analytical strategy called internal extractive electrospray ionization mass spectrometry (iEESI-MS), which combines solvent extraction of chemicals inside a bulk sample with in situ spectrometry, has been established to directly characterize the interior molecular specificity. The method allows both qualitative and quantitative analysis analytes distributed 3-dimensional volume (e.g., 1 ~ 100 mm3) various synthetic biological matrices chewing gum, leaves, fruits, roots,...
Accumulating evidence has demonstrated that mitochondrial dysfunction is a prominent early event in the progression of Alzheimer’s disease (AD). Whether protecting function can reduce amyloid-β oligomer (AβO)-induced neurotoxicity PS1 V97L transgenic mice remains unknown. In this study, we examined possible protective effects honokiol (HKL) on induced by AβOs neurons, and cognitive AD mice. We determined HKL increased sirtuin 3 (SIRT3) expression levels activity, which turn markedly improved...
Abstract Tissue spray ionization mass spectrometry (TSI-MS) directly on small tissue samples has been shown to provide highly specific molecular information. In this study, we apply method the analysis of 38 pairs human lung squamous cell carcinoma (cancer) and adjacent normal (normal). The main components pulmonary surfactants, dipalmitoyl phosphatidylcholine (DPPC, m/z 757.47), (POPC, 782.52), oleoyl (DOPC, 808.49) arachidonic acid stearoyl (SAPC, 832.43), were identified using...
Abstract Introduction Alzheimer's disease (AD) is associated with altered metabolites. This study aimed to determine the validity of using circulating metabolites differentiate AD from other dementias. Methods Blood were measured in three data sets. Data set 1 (controls, 27; AD, 28) was used for analyzing differential 2 93; 92) establish a diagnostic model use metabolite panel. The applied 3 76; dementias, 205) verify its capacity differentiating Results revealed 7 upregulated and 77...
To analyze the relationship between titin (TTN) mutation gene and tumor mutational burden (TMB) with prognosis of lung squamous cell carcinomas (LUSC), to explore feasibility TTN as a potential prognostic marker for LUSC. We analyzed somatic landscape LUSC samples using datasets obtained from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Sequence data were divided into wild mutant groups, differences in TMB values groups compared Mann-Whitney U-test. Kaplan Meier...
Abstract Oxidative stress refers to an imbalance between oxidative and antioxidative systems due environmental factors. Although is implicated in the pathogenesis of Alzheimer's disease (AD), its precise role not yet understood. We aimed investigate pathogenic mechanisms by using vitro cultured neurons vivo AD models PS1V97L‐transgenic (Tg) mice. Our results showed that when became increasingly evident, endogenous protective pathway nuclear factor E2‐related 2 (Nrf2)/antioxidant response...
Coccidioidomycosis, also known as Valley fever (VF), is a potentially lethal fungal infection that results in more than 200 deaths per year the United States. Despite important role of metabolic processes molecular pathogenesis VF, robust markers to enable effective screening, rapid diagnosis, accurate surveillance, and therapeutic monitoring VF are still lacking. We present targeted liquid chromatography–tandem mass spectrometry-based profiling approach for identifying marker candidates...
Background: Osteoporosis is a major clinical problem in elderly men and women. The correlation between total cholesterol bone mineral density remains controversial. NHANES the cornerstone for national nutrition monitoring to inform health policy. Methods: Sample sizes location of study time when it was conducted: we obtained 4236 non-cancer from (National Health Nutrition Examination Survey) database 1999 2006. Data were analyzed with use statistical packages R EmpowerStats. We relationship...
Abstract Aim This study investigated the scientific research ability of Chinese specialist nurses (SNs) in Guangxi Zhuang Autonomous Region and its influencing factors. Design A cross‐sectional design. Methods total 652 SNs were from March to October 2021. The nursing level was measured using Nursing Research Competence Nurses Self‐evaluation Scale. Descriptive statistics, univariate analysis ordinal logistic regression used evaluate factors affecting SNs. Results median score 31...