A5101476190- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Galectins and Cancer Biology
- Cancer-related gene regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Fungal Biology and Applications
- Extracellular vesicles in disease
- RNA regulation and disease
- Powdery Mildew Fungal Diseases
- Cardiovascular Disease and Adiposity
- Lung Cancer Treatments and Mutations
- Genetic Mapping and Diversity in Plants and Animals
- Angiogenesis and VEGF in Cancer
- Developmental Biology and Gene Regulation
Nanchang University
2017-2022
Second Affiliated Hospital of Nanchang University
2017-2022
Jinan University
2021
Shuguang Hospital
2020-2021
Shanghai University of Traditional Chinese Medicine
2020-2021
Shandong Agricultural University
2021
Zhuhai People's Hospital
2021
Shanghai University
2020
Peking University
2013-2018
Peking University Cancer Hospital
2009-2018
The dysregulation of circular RNA (circRNA) expression is involved in the progression several cancers, including non-small cell lung cancer (NSCLC). However, role and underlying molecular mechanisms circRNA FGFR3 (circFGFR3) NSCLC remains unknown. Here, we used quantitative real-time polymerase chain reaction to validate that circFGFR3 was higher tissues than paratumor tissues. Furthermore, our study indicated forced promoted invasion proliferation. Mechanistically, found proliferation via...
Abstract Exosomes are nanosized bilayer membrane vesicles that may mediate intercellular communication by transporting bioactive molecules, including noncoding RNAs, mRNAs, and proteins. Research has shown exosomes play an important role in acute myocardial infarction (AMI), but the function regulation of exosomal long RNAs (lncRNAs) AMI unclear. Thus, RNA sequencing (RNA-Seq) was conducted to investigate lncRNA transcriptome from MI patients identified 65 differentially expressed lncRNAs...
To analyze the relationship between titin (TTN) mutation gene and tumor mutational burden (TMB) with prognosis of lung squamous cell carcinomas (LUSC), to explore feasibility TTN as a potential prognostic marker for LUSC. We analyzed somatic landscape LUSC samples using datasets obtained from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Sequence data were divided into wild mutant groups, differences in TMB values groups compared Mann-Whitney U-test. Kaplan Meier...
This study explored the relationships among expression of LAPTM4B, VEGF, and survivin clinicopathological characteristics prognosis in breast cancer patients.The these three molecules 110 stage I-III patients with follow-up data was detected via immunohistochemistry. Kaplan-Meier Cox proportional hazard regression analyses were performed to assess prognostic significance markers cancer. Moreover, levels evaluated 5 cell lines Western blot analysis.LAPTM4B, over-expressed specimens highly...
To explore the immunoregulatory effects of circ_CELF1 in non-small cell lung cancer (NSCLC).The mRNA level primary tissue samples was analyzed by qRT-PCR. The assays CCK-8, colony formation, wound healing as well Transwell were employed for measurement malignant transformation. murine subcutaneous tumor model used to assess tumorigenesis NSCLC vivo. circRNA precipitation, RNA immunoprecipitation, and luciferase reporter performed study relationship between circ_CELF1, miR-491-5p,...
// Jianwen Xiong 1, * , Xiaoqiang Zhang Xianglai Chen 1 Yiping Wei De-guo Lu 2 Yun-wei Han Jianjun Xu Dongliang Yu Department of Cardiothoracic Surgery, The Second Affiliated Hospital Nanchang University, Nanchang, Jiangxi Province 330006, P. R. China Oncology, Southwest Medical Luzhou, Sichuan 646000, These authors have contributed equally to this work Correspondence to: Yu, email: dongliangyumd@yahoo.com Xu, Jianjunxua@gmail.com Keywords: NSCLC, notch, hazard ratio, prognosis, KM plotter...
Polymorphisms of the lysosomal‐associated protein transmembrane‐4 beta ( LAPTM 4B) gene are related to various forms tumour susceptibility, which led us hypothesize that some unique transcription factors targeting this polymorphism region may affect biological function 4B in progression. In study, we found factor AP 4 directly binds promoter and induces its transcription. addition, demonstrated promotes hepatocellular carcinoma (HCC) cell proliferation metastasis depresses chemotherapy...
The study aims to evaluate serum VEGF expression in gastric cancer patients and investigate its relationship with clinicopathological parameters. We also examined the levels GC having received surgery or chemotherapy treatment assess predictive prognostic value as a biomarker. enrolled 154 not neoadjuvant 100 healthy controls. In groups, 13 15 were investigated. 42 different efficacy recruited well. was by ELISA. Serum level remarkably upregulated group compared (p < 0.001). of significantly...
Abstract Background Previous studies have reported the role of circular RNAs (circRNAs) in progression non‐small‐cell lung cancer (NSCLC). SWT1‐derived circRNAs were confirmed to affect apoptosis cardiomyocytes; however, biological functions cancers are still unknown. Here, we investigated potential NSCLC. Methods We used quantitative real‐time polymerase chain reaction (qRT‐PCR) measure expression circSWT1 NSCLC tissues and paired normal tissues. The tumor assessed by CCK‐8, colony...
In this study, 3 chloroplast sequences (rnL-trnF, rpl20-rps12, and rbcl) were amplified sequenced in 236 individuals from 12 wild rose (Rosa rugosa) populations China to determine their genetic diversity, differentiation pedigree geographic structure order provide information necessary for formulating protection strategies. total, 19 haplotypes obtained. The gene flow (Nm) among the was 0.7, species exhibited low overall diversity (Ht = 0.427 ± 0.0863). coefficients of Nst 0.270 > Gst 0.197...
Lysosomal-associated protein transmembrane 4 beta (LAPTM4B) is known as an oncogene associated with many human malignant tumors. There are two alleles of the gene, LAPTM4B*1 and LAPTM4B*2. Previous studies have shown that LAPTM4B polymorphism contributes to risk cancers. This case-control study was investigate relationship between gene susceptibility melanoma. The genotypes were determined in 617 control subjects 220 patients melanoma by utilizing polymerase chain reaction based on specific...
As some evidence has demonstrated the role of microRNA-221 (miR-221) on coronary heart disease (CHD), aim present study was to investigate effect miR-221-3p CHD via regulating NLRP3/ASC/pro-caspase-1 inflammasome pathway.Sixty patients and 60 healthy controls were collected detect expression miR-221-3p, NLRP3, ASC, pro-caspase-1 in peripheral blood contents related factors serum. The rats model injected with agomir or antagomir explore its functions ASC expression, electrocardiogram data,...
Objective To establish a SYBR green Ⅰ real-time PCR method for detecting serum miR-21 and preliminarily explore its value in diagnosing breast cancer.Methods Total RNA was extracted from by Trizol reagent.Then miR-16 ( internal reference gene ) were reverse transcribed into corresponding cDNA stem-loop RT primers.Their amplified detected using PCR.The accuracy of assay analyzed signal to noise ratio (SNR) ; the specificity evaluated melting curve; precision assessed R2 standard curve...
Objective To investigate uPA expression in three breast cancer cell lines with different invasive and metastatic potentials. Methods at mRNA level was detected by RT-PCR FQ-PCR. protein examined western blot analysis immunocytochemistry the of MCF7 (low metastatic), MDA231 (medium metastatic) BICR-H1 (high metastatic). Results The results showed that reference gene GAPDH expressed similarly lines,and 227 bp, but not BICR-H1; FQ-PCR cross point values BICR-H1, were 36. 93, 31.51 36.73...