Abstract Background Meteorin-like hormone (Metrnl) is prominently expressed in activated M2 macrophages and has demonstrated potential therapeutic effects a range of cardiovascular diseases by modulating inflammatory responses. Nevertheless, its precise role the underlying mechanisms myocardial ischemia/reperfusion injury (MI/RI) are not fully understood. This study examined whether Metrnl can mitigate MI/RI through AMPK-mediated polarization macrophages. Methods In vivo, adeno-associated...

Cardiovascular diseases (CVDs) have emerged as a predominant threat to human health, surpassing the incidence and mortality rates of neoplastic diseases. Extracellular vesicles (EVs) serve vital mediators in intercellular communication material exchange. Endothelial progenitor cells (EPCs), recognized precursors vascular endothelial (ECs), garnered considerable attention recent years due potential therapeutic value their derived extracellular (EPC-EVs) context CVDs. This comprehensive review...

Autoimmunity is involved in the valvular damage caused by rheumatic heart disease (RHD). Increased evidence has linked microRNAs (miRNAs/miRs) to autoimmune disease. Signal transducer and activator of transcription 3 (STAT3) sphingosine‑1‑phosphate receptor 1 (S1PR1) suppressor cytokine signaling (SOCS1) have been widely studied for their roles autoimmunity inflammation. Thus, current study aims investigate role played miR‑155‑5p RHD‑induced via S1PR1, SOCS1/STAT3 interleukin (IL)‑6/STAT3...

Abstract Exosomes are nanosized bilayer membrane vesicles that may mediate intercellular communication by transporting bioactive molecules, including noncoding RNAs, mRNAs, and proteins. Research has shown exosomes play an important role in acute myocardial infarction (AMI), but the function regulation of exosomal long RNAs (lncRNAs) AMI unclear. Thus, RNA sequencing (RNA-Seq) was conducted to investigate lncRNA transcriptome from MI patients identified 65 differentially expressed lncRNAs...

MicroRNA (miR)-143-3p is a potential regulatory molecule in myocardial ischemia/reperfusion injury (MI/RI), wherein its expression and pathological effects remains controversial. Thus, mouse MI/RI cell hypoxia/reoxygenation (H/R) models were built for clarifying the miR-143-3p's role MI/RI. Following ischemia 30 min, mice underwent reperfusion 3, 6, 12 24 h. It was found miR-143-3p increased ischemic heart tissue over time after reperfusion. Cardiomyocytes transfected with more susceptible...

Abstract Patients with acute myocardial infarction complicated diabetes are more likely to develop ischemia/reperfusion (I/R) injury (MI/RI) during reperfusion therapy. Both HMGB1 and RAGE play important roles in MI/RI. However, the specific mechanisms of associated not fully clarified diabetic This study aimed investigate whether HMGB1-RAGE axis induces MI/RI via regulating autophagy apoptosis. A db/db mouse model was established, where anti-HMGB1 antibody inhibitor (FPS-ZM1) were...

Oridonin (ORI), the major pharmacological component extracted from a traditional Chinese medicine, possesses beneficial effect on myocardial ischemia/reperfusion (I/R) injury. However, underlying molecular mechanism by which ORI effects take place is not completely known. Thus, whether works via downregulating oxidative stress and nod-like receptor protein-3 (NLRP3) inflammasome pathway was investigated in this study. Mice underwent surgery to induce I/R injury, some were administered (10...

The specific pathophysiological pathways through which diabetes exacerbates myocardial ischemia/reperfusion (I/R) injury remain unclear; however, dysregulation of immune and inflammatory cells, potentially driven by abnormalities in their number function due to diabetes, may play a significant role. In the present investigation, we simulated I/R inducing ischemia ligation left anterior descending coronary artery mice for 40 min, followed reperfusion 24 h. Previous studies have indicated that...

Background: Rheumatic heart disease (RHD), which is caused mainly by Group A Streptococcus, leads to fibrotic damage valves. Recently, endothelial‒mesenchymal transition (EndMT), in activin plays an important role, has been shown be factor RHD valvular injury. However, the mechanism of activity and EndMT injury not clear. Methods: Our study was divided into two parts: vivo vitro. We constructed a small interfering RNA (ACVR2A-siRNA) silencing receptor type IIA (ACVR2A) adeno-associated virus...

Atherosclerosis is a chronic inflammatory disease that strongly threatens human health, and macrophages play pivotal role in its pathogenesis. Ubiquitin-specific peptidase 22 (USP22) involved the regulation of macrophage inflammation. However, atherosclerotic microenvironment remains unclear. In this study, we found USP22 overexpression alleviated atherosclerosis progression ApoE-/- mice. vitro, silencing enhanced inflammation foam cell formation, efferocytosis was significantly impaired....

Rheumatic heart disease (RHD) is an autoimmune caused by rheumatic fever following group A hemolytic streptococcal infection and primarily affects the mitral valve. RHD currently a major global health problem. However, exact pathological mechanisms associated with RHD‑induced cardiac valve damage remain to be elucidated. The endothelial‑mesenchymal transition (EndMT) serves key role in number of diseases important fibrosis activin/Smad2 3 signaling pathway involved regulating EndMT....

Myocardial ischemia-reperfusion injury (MIRI) is a common complication of acute myocardial infarction that seriously endangers human health. Cinnamon, traditional Chinese medicine, has been used to counteract MIRI as it shown possess anti-inflammatory and antioxidant properties. To investigate the mechanisms action cinnamon in treatment MIRI, deep learning-based network pharmacology method was established predict potential active compounds targets. The results showed oleic acid, palmitic...

Background: Rheumatic heart disease (RHD) is an autoimmune caused by recurrent infections of Group A streptococcus (GAS), ultimately leading to inflammation and the fibrosis valves. Recent studies have highlighted crucial role C-C chemokine receptor type 2-positive (CCR2+) macrophages in diseases tissue fibrosis. However, specific involvement CCR2+ RHD remains unclear. Methods: This study established rat model using inactivated GAS complete Freund’s adjuvant, demonstrating a correlation...

Rheumatic heart disease (RHD) affects numerous individuals annually; however, its pathogenesis remains unclear. The sphingosine 1‑phosphate receptor 1 (S1PR1) and signal transducer activator of transcription 3 (STAT3) have recently been shown to be involved in valvular damage via the promotion differentiation T helper 17 (Th17) cells during development RHD‑induced damage. present study investigated whether altering expression S1PR1 or STAT3 attenuates due RHD. Inactivated group A...

Abstract Rheumatic heart disease (RHD) is an important and preventable cause of cardiovascular death disability, but the lack clarity about its exact mechanisms makes it more difficult to find alternative methods or prevention treatment. We previously demonstrated that increased IL-17 expression plays a crucial role in development RHD-related valvular inflammatory injury. Macrophage autophagy/polarization may be pro-survival strategy initiation resolution process. This study investigated...

There is a lack of an effective prognostic model for predicting outcomes in patients with primary pulmonary hypertension (PPH). A retrospective analysis was conducted on PPH from MIMIC and eICU databases. predictive developed to assess mortality risk. The Consistency Index (C-index) Receiver Operating Characteristic (ROC) curve were utilized the overall performance its discriminatory capacity. model's calibration clinical applicability assessed through decision (DCA). nomogram employed...

Abstract Background : Rheumatic heart disease (RHD) is an autoimmune caused by rheumatic fever following infection with Group A Streptococcus (GAS) that primarily affects the mitral valve, and our previous study has shown endothelial-mesenchymal transition (EndMT) plays important role in valve damage due to RHD. TGF-β1 profibrotic factor, but its not been explored The current aimed investigate of Methods RHD rats were established using inactivated GAS. Successful modelling rat was verified...

Abstract Background Rheumatic heart disease (RHD) is a social health problem that affects many patients every year, but its pathogenesis still unclear. Recent studies have found the sphingosine 1-phosphate receptor 1 (S1PR1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway activated during development valvular damage caused by RHD. STAT3 plays an important role in differentiation CD4 + T cells into helper 17 (Th17) cells, Th17 cell-related cytokines are involved...

Abstract Background: Rheumatic heart disease (RHD) affects many patients every year, but its pathogenesis is still unclear. Recent studies have found that the sphingosine 1-phosphate receptor 1 (S1PR1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway involved in valvular damage by promoting differentiation T helper 17 (Th17) cells during development caused RHD. In this work, we investigated whether altering S1PR1/STAT3 attenuates due to Methods: Inactivated Group...