A5010124184- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Gastroesophageal reflux and treatments
- Long-Term Effects of COVID-19
- Memory and Neural Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
- Pancreatitis Pathology and Treatment
- Inflammasome and immune disorders
- Melanoma and MAPK Pathways
- Evolutionary Psychology and Human Behavior
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
Shanghai Xiandai Architectural Design
2025
Huazhong University of Science and Technology
2015-2024
Union Hospital
2014-2024
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2024
First Affiliated Hospital of Zhengzhou University
2023-2024
Northeast Petroleum University
2024
Southern University of Science and Technology
2023
Tongji Hospital
2023
Peking University
2022-2023
Peking University Third Hospital
2022-2023
Summary Background To date, large amounts of epidemiological and case study data have been available for the Coronavirus Disease 2019 (COVID-19), which suggested that mortality was related to not just respiratory complications. Here, we specifically analyzed kidney functions in COVID-19 patients their relations mortality. Method In this multi-centered, retrospective, observational study, included 193 adult with laboratory-confirmed from 2 hospitals Wuhan, 1 hospital Huangshi (Hubei province,...
Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions the intact amygdala and prefrontal cortex are required for emotion-based that relies on ability to assess risk, attribute value, identify advantageous strategies. We tested hypothesis pain-related cognitive result from amygdala-driven impairment medial cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo , patch clamp brain slices, various...
Abstract Background Recurrent abdominal pain is a common and costly health‐care problem attributed, in part, to visceral hypersensitivity. Increasing evidence suggests that gut bacteria contribute perception by modulating the microbiome‐gut‐brain axis. However, specific microbial signals remain poorly defined. γ ‐aminobutyric acid ( GABA ) principal inhibitory neurotransmitter key regulator of central from peripheral afferent neurons. Although are reported produce , it not known whether...
Background: To date, large amounts of epidemiological and case study data have been available for the Coronavirus Disease 2019 (COVID-19), which suggested that mortality was related to not just respiratory complications. Here, we specifically analyzed kidney functions in COVID-19 patients their relations mortality.Methods: In this multi-centered, retrospective, observational study, included 193 adult with laboratory-confirmed from 2 hospitals Wuhan, 1 hospital Huangshi (Hubei province, 83 km...
A major site of extrahypothalamic expression corticotropin-releasing factor (CRF) and its G-protein-coupled CRF1 CRF2 receptors is the amygdala, a key player in emotions affective disorders. Pain-related plasticity laterocapsular division central nucleus amygdala (CeLC) generates emotional-affective responses anxiety-like behavior. receptor antagonists have anxiolytic effects. Although both couple positively to adenylyl cyclase, they can opposite effects, but underlying mechanism unknown....
Background and Aims Research has increasingly suggested that gut flora plays an important role in the development of post-infectious irritable bowel syndrome (PI-IBS). Studies curative effect probiotics for IBS have usually been positive but not always. However, differences treatment effects mechanisms among probiotic stains, or mixture them, are clear. In this study, we compared different (Befidobacterium, Lactobacillus, Streptococcus three) on intestinal sensation, barrier function...
Background and Aims In December 2019, an outbreak of coronavirus disease 2019 (COVID‐19) emerged in Wuhan, China. Although it has been reported that some patients with COVID‐19 showed elevated liver biochemistries, there are few studies regarding the clinical features prognosis these patients. Approach Results this multicenter, retrospective study, we collected data on laboratory‐confirmed from three hospitals China, who died or were discharged between February 1, 2020, 20, 2020. Data...
Background: A previous study has shown that 81% of the COVID-19 patients had mild or moderate symptoms. However, most studies on sequelae in focused severe cases and long-term follow-up health consequences non-severe are limited. The current aimed to assess nearly 1 year after diagnosis with a particular focus recovery COVID-19. Methods: We enrolled 120 infected SARS-CoV-2 discharged from Wuhan Union hospital west district (designated for COVID-19) Fangcang shelter hospitals between January...
Neurons express multiple types of voltage-gated calcium (Ca 2+ ) channels. Two subtypes neuronal L-type Ca channels are encoded by V 1.2 and 1.3 pore-forming subunits. Both subunits contain class I PDZ (postsynaptic density-95/Discs large/zona occludens-1) domain-binding consensus at their C termini. In yeast two-hybrid screen rat brain cDNA library with the C-terminal bait 1.3a (long splice variant) channel subunit, we isolated clones postsynaptic adaptor protein Shank. We demonstrated a...
Corticotropin-releasing factor receptor CRF1 has been implicated in the neurobiological mechanisms of anxiety and depression. The amygdala plays an important role affective states disorders such as is also emerging a neural substrate pain affect. However, involvement interaction remains to be determined. This study tested hypothesis that receptors are critically involved pain-related anxiety. Anxiety-like behavior was determined adult male rats using elevated plus maze (EPM) test. open-arm...
Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be most neurotoxic A beta species affecting brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death CNS. Recent evidence indicates that oligomers recruited at synapse, oppose expression long-term potentiation (LTP), perturb intracellular calcium balance, disrupt dendritic spines,...
Hypokalemic periodic paralysis (HypoPP) is a familial skeletal muscle disorder that presents with recurrent episodes of severe weakness lasting hours to days associated reduced serum potassium (K+). HypoPP genetically heterogeneous, missense mutations calcium channel (CaV1.1) or sodium (NaV1.4) accounting for 60% and 20% cases, respectively. The mechanistic link between CaV1.1 the ictal loss excitability during an attack in unknown. To address this question, we developed mouse model targeted...
Research supports an association between extraversion and dopamine (DA) functioning. DA facilitates incentive motivation the conditioning encoding of contexts that predict reward. Therefore, we assessed whether is related to efficacy acquiring conditioned contextual facilitation three processes are dependent on DA: motor velocity, positive affect, visuospatial working memory. We exposed high low extraverts days drug reward (methylphenidate, MP) with a particular laboratory context (Paired...
Background Corticotropin-releasing factor (CRF) plays an important role in affective states and disorders. CRF is not only a “stress hormone” but also neuromodulator outside the hypothalamic-pituitary-adrenocortical (HPA) axis. The amygdala, brain center for emotions, major site of extrahypothalamic expression its G-protein-coupled receptors. Our previous studies showed that endogenous activation CRF1 receptors arthritis pain model contributes to amygdala hyperactivity pain-related...
Hypoalbuminemia has been reported in COVID-19 patients. Exploring the influencing factors and possible adverse consequences of albumin reduction may provide some guidance for treatment
Atrial Natriuretic Peptide (ANP) has known anti-inflammatory effects.However, the role of ANP in Ulcerative colitis (UC) remains unclear.This study aimed to explore expression and function UC, its potential regulatory stimulator interferon genes (STING) pathway.Human colon biopsy serum samples were collected between September 2018 December 2019 at Wuhan Union Hospital.Levels receptors STING pathway components detected people with UC mice dextran sulfate sodium (DSS)-induced colitis.These...
Background BAFF production is increased in IBD patients. However, the specific role of still uncovered. This study aimed to investigate expression and function experimental colitis potential mechanisms. Methods levels serum colon tissues were measured by ELISA DSS-induced mice. Mouse-derived antibody was administered DSS The changes body weight, disease activity index (DAI) scores, length, spleen histopathological damage, inflammatory indicators, NF-κB signaling, NLRP3 inflammasome assayed...
Hypertension, sleep disorders, and depression are highly prevalent in the elderly population all associated with cognitive impairment, but role that quality play association between hypertension impairment is unclear. The aim of this study was to investigate whether have a mediating impairment.A cross-sectional conducted collect data from Tongji Hospital Comprehensive Geriatric Assessment Database. Sleep quality, function were measured by Pittsburgh Quality Index (PSQI), Depression Scale...
Mitochondrial transfer plays an important role in various diseases, and many mitochondrial biological functions can be regulated by HMGB1. To explore the of hepatocellular carcinoma (HCC) its relationship with HMGB1, field emission scanning electron microscopy, immunofluorescence, flow cytometry were used to detect between HCC cells. We found that cells was confirmed using tunnel nanotubes (TNTs). The mitochondria from highly invasive less could enhance migration invasion ability latter....