A5034351703- Mitochondrial Function and Pathology
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Air Quality and Health Impacts
- Particle Detector Development and Performance
- Optical Coherence Tomography Applications
- Particle physics theoretical and experimental studies
- Reproductive System and Pregnancy
- Photoacoustic and Ultrasonic Imaging
- Indoor Air Quality and Microbial Exposure
- Adipose Tissue and Metabolism
- Astrophysics and Cosmic Phenomena
- Education and Work Dynamics
- MicroRNA in disease regulation
- Odor and Emission Control Technologies
- RNA modifications and cancer
- Neutrino Physics Research
- Gaussian Processes and Bayesian Inference
- Dark Matter and Cosmic Phenomena
- Autophagy in Disease and Therapy
- Water Quality Monitoring Technologies
- Retinal and Macular Surgery
- Nuclear Physics and Applications
- Climate Change and Health Impacts
University of California, Riverside
2016-2025
Beijing University of Civil Engineering and Architecture
2024
China Agricultural University
2024
Nanjing Agricultural University
2018-2024
Changchun University of Science and Technology
2023-2024
UC Irvine Health
2024
University of California, Irvine
2023
Hefei Meiling (China)
2023
Xi’an University of Posts and Telecommunications
2021-2023
Ministry of Agriculture and Rural Affairs
2021-2022
Using detailed simulations of calorimeter showers as training data, we investigate the use deep learning algorithms for simulation and reconstruction particles produced in high-energy physics collisions. We train neural networks on shower data at calorimeter-cell level, show significant improvements when using these compared to methods which rely currently-used state-of-the-art algorithms. define two models: an end-to-end network performs simultaneous particle identification energy...
Changes in endometrial cell morphology and function are absolutely necessary for successful embryo implantation. In this study, miR‐26a was widely expressed dairy goats, found to be regulated by β‐estradiol (E2) progesterone (P4) epithelium cells (EECs) as well stromal (ESCs). Furthermore, played a role the regulation of proliferation apoptosis directly regulating PTEN indirectly PI3K/AKT pathway EECs but not ESCs goats vitro. addition, expression osteopontin (OPN), vascular endothelial...
Particulate matter (PM) is a carrier of many substances. Microorganisms are vital constituents contained in PM, and their varieties concentrations closely connected to human health animal production. This study aimed investigate the distribution characteristics bioaerosols inside pig house respiratory tract pigs. Environmental indices nursery were monitored winter, including temperature, relative humidity, total suspended particulate (TSP), PM10, PM2.5, NH3, CO2, CO NO. The airborne...
Abstract Due to dissimilarities in genetics and metabolism, current animal models cannot accurately depict human neurological diseases. To develop patient‐specific vitro neural models, a functional material‐based technology that offers multi‐potent stimuli for enhanced tissue development is devised. An electrospun piezoelectric poly(vinylidene fluoride‐trifluoroethylene) (P(VDF‐TrFE)) nanofibrous scaffold systematically optimized maximize its properties while accommodating the cellular...
This study aimed to investigate whether dietary fiber pectin can alleviate PM2.5-induced pulmonary inflammation and the potential mechanism. PM2.5 samples were collected from a nursery pig house. The mice divided into three groups: control group, group + group. in intratracheally instilled with suspension twice week for four consecutive weeks, those subject same exposure, but fed basal diet supplemented 5% pectin. results showed that body weight feed intake not different among treatments (p...
Biomechanical forces have been shown to significantly affect tissue development, morphogenesis, pathogenesis and healing, especially in orthopaedic tissues. Such biological processes are critically related the differentiation of human mesenchymal stem cells (hMSCs). However, mechanistic details regarding how mechanical direct MSC subsequent formation still elusive. Electrospun three-dimensional scaffolds were used culture subject hMSCs various magnitudes dynamic compressive strains at 5, 10,...
The training process of a domain generalization (DG) model involves utilizing one or more interrelated source domains to attain optimal performance on an unseen target domain. Existing DG methods often use auxiliary networks require high computational costs improve the model's ability by incorporating diverse set domains. In contrast, this work proposes method called Smooth-Guided Implicit Data Augmentation (SGIDA) that operates in feature space capture diversity To amplify capacity,...
The ability to detect and localize sperm in the testes is crucial for treatment of non-obstructive azoospermia (NOA), a condition where retrieval challenging due lack visible sperm. Enhancing accuracy efficiency detection can significantly improve outcomes microdissection testicular extraction (micro-TESE) procedures NOA patients. We aim use optical coherence tomography (OCT) presence or absence imaged areas sperm-containing seminiferous tubules rat model NOA. Volumetric OCT scanning was...
Purpose: To evaluate the potential for artificial intelligence-based video analysis to determine surgical instrument characteristics when moving in three-dimensional vitreous space. Methods: We designed and manufactured a model eye which we recorded choreographed videos of many instruments throughout eye. labeled each frame describe tool characteristics: type, location, depth, insertional laterality. trained two different deep learning models predict evaluated performances on subset images....
Abstract Generation of simulated detector response to collision products is crucial data analysis in particle physics, but computationally very expensive. One subdetector, the calorimeter, dominates computational time due high granularity its cells and complexity interactions. Generative models can provide more rapid sample production, currently require significant effort optimize performance for specific geometries, often requiring many describe varying cell sizes arrangements, without...
A high-salt diet is a cause of gastritis, but the associated mechanism remains unclear. Recent studies have shown that gastric flora with variety stomach diseases, it not known whether involved in gastritis induced by diet.Gastritis successfully C57BL/6 mice fed (salt: 5% NaCl) for four weeks. Through 16S rRNA gene sequencing, composition microbiota normal and diets are compared, results which show induces significant changes flora. Phylogenetic investigation communities reconstruction...
Increasing evidence has shown that miRNAs play important roles in endometrium development during the menstrual cycle humans and many other animals. Our previous data indicated miR-182 levels increase 15.55-fold pleiotrophin (PTN) decrease 20.97-fold receptive (RE, D15) compared with pre-receptive (PE, D5) dairy goats. The present study shows is widely expressed different tissues of goats its expression are regulated by E2 P4 endometrial epithelium cells (EECs). We confirmed PTN a target...
The dysbiosis of lung microbiota and inflammatory factors play a crucial role in the occurrence lipopolysaccharides (LPS)-induced injury. Recently, mogroside V (MGⅤ) has received increasing attention due to its potential health benefits pneumonia, but complex mechanism needs further experimental elucidation. In this study, we established an LPS-induced chicken injury model investigate protective effect MGⅤ on acute broiler related mechanisms. A total 192 1-day-old white-finned broilers were...
In this study, an RT-qPCR analysis showed that the expression levels of miR-449a in pre-receptive endometrium were lower compared to receptive endometrium, which is consistent with previous sequencing data (previous investigations). To detect role endometrial receptivity, we transfected caprine stromal cells (ESCs) cultured vitro mimics. The results revealed decreased mRNA and protein LGR4 by targeting its 3'-untranslated region. mimics significantly reduced G1 cell population from 52.56%...
Abstract Chronic persistent stress is an important cause of gastritis, but the underlying mechanism remains to be further researched, especially role gastric microbiota in this process. Here, we used water avoidance (WAS) test mouse models for chronic stress‐induced gastritis investigate mechanisms disease. The effect on was analyzed based 16S rRNA sequencing; changes hydrogen sulfide (H 2 S) and inflammatory cytokine levels tissues were detected by Western blotting, ELISA,...
ABSTRACT The gut microbiota of poultry is influenced by a variety factors, including feed, drinking water, airborne dust, and footpads, among others. Gut can affect the immune reaction inflammation in lungs. To investigate effect variation on lung induced PM 2.5 (fine particulate matter) broilers, 36 Arbor Acres (AA) broilers were randomly assigned to three groups: control group (CON), exposure (PM), plus oral antibiotics (PMA). We used non-absorbable (ABX: neomycin amikacin) modify...
Mitochondrial dysfunction is the key pathogenic mechanism of cerebral injury induced by high-altitude hypoxia. Some Chinese herbal monomers may exert anti-hypoxic effects through enhancing efficiency oxidative phosphorylation. In this study, 10 kinds on mitochondrial respiration and membrane potential mitochondria isolated from hypoxia-exposed rats in vitro were investigated to screen drugs. Rats exposed a low-pressure environment 405.35 mm Hg (54.04 kPa) for 3 days establish hypoxic models....
A conventional optical lens can enhance lateral resolution in coherence tomography (OCT) by focusing the input light onto sample. However, typical Gaussian beam profile of such a will impose tradeoff between depth focus (DOF) and resolution. The is often compromised to achieve mm-scale DOF. We have experimentally shown that using cascade system an ultrasonic virtual tunable waveguide (UVTOW) short focal-length provide large DOF without severely compromising compared external with same...
It is widely stated in the literature that closed mature autophagosomes (APs) fuse with lysosomes/vacuoles during macroautophagy/autophagy. Previously, we showed unclosed APs accumulated as clusters outside vacuoles Vps21/Rab5 and ESCRT mutants after a short period of nitrogen starvation. However, fate such remains unclear. In this study, used combination cellular biochemical approaches to show double-membrane entered formed single-membrane autophagic bodies prolonged starvation or rapamycin...