A5101922905- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Enhanced Recovery After Surgery
- Airway Management and Intubation Techniques
- Reproductive Physiology in Livestock
- Nitric Oxide and Endothelin Effects
- Respiratory Support and Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Surgical Treatments
- Infant Health and Development
- COVID-19 Clinical Research Studies
- Acupuncture Treatment Research Studies
- Renin-Angiotensin System Studies
- Nosocomial Infections in ICU
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Advanced Measurement and Detection Methods
- Regulation of Appetite and Obesity
- Alcohol Consumption and Health Effects
- Soil Carbon and Nitrogen Dynamics
- Stress Responses and Cortisol
- Healthcare and Venom Research
- Agriculture, Soil, Plant Science
- Hormonal Regulation and Hypertension
- SARS-CoV-2 and COVID-19 Research
Peking University People's Hospital
2013-2025
Peking University
2013-2025
Shanghai University of Sport
2025
First Affiliated Hospital Zhejiang University
2019-2024
Beijing University of Agriculture
2024
Beijing Geriatric Hospital
2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
China Meteorological Administration
2024
Jiamusi University
2023
China has a large population of older people, but not yet undertaken comprehensive study on the prevalence, risk factors, and management both dementia mild cognitive impairment (MCI).For this national cross-sectional study, 46 011 adults aged 60 years or were recruited between March 10, 2015, Dec 26, 2018, using multistage, stratified, cluster-sampling method, which considered geographical region, degree urbanisation, economic development status, sex age distribution. 96 sites randomly...
Nirmatrelvir-ritonavir, also known as paxlovid, is a widely used antiviral drug against coronavirus disease 2019 (COVID-19). Azvudine, previously to treat human immunodeficiency virus-1, has been COVID-19 in China. However, only few clinical studies have evaluated the effects of azvudine. Additionally, comparing nirmatrelvir-ritonavir with azvudine limited number.We carried out retrospective case‒control analysis at Third People's Hospital Tibet Autonomous Region. Eighty-two eligible...
To analyze the clinical characteristics, microbiological analysis, and drug resistance patterns of intensive care unit (ICU) bloodstream infection. A prospective cohort study method was employed to collect data from patients suspected infection (BSI) during their stay in ICUs across 67 hospitals 16 provinces cities nationwide, July 1, 2021, December 31, 2022. Electronic collection technology used gather general information on ICU patients, including gender, age, length hospital stay, as well...
Shear stress is one of the most important stimulators for release endothelium-derived relaxing factors. Although shear stress-induced nitric oxide (NO) has been extensively investigated, it remains to be elucidated whether hyperpolarizing factor (EDHF) contributes endothelium-dependent relaxations stress. This study was designed address this point in isolated rat mesenteric artery. Large arteries (400-500 μm) and resistance (150-250 were precontracted with phenylephrine (at 80 mm Hg...
Hematological malignant tumors represent a group of major diseases carrying substantial risk to the lives affected patients. Risk factors for mortality in critically ill patients have garnered attention recent research endeavors. The present aimed identify predicting intensive care unit (ICU) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, study analyzed and compared rate between haploidentical (Haplo-SCT) those identical sibling donor (ISD)...
Ketosis, especially its subclinical form, is frequently observed in high-yielding dairy cows and linked to various diseases during the transition period. Although adipose tissue plays a significant role development of metabolic disorders, exact impact on emergence ketosis (SCK) still poorly understood. The objectives this study were characterize compare profiling transcriptome lipidome blood between SCK healthy investigate potential correlation disorders lipid metabolism. We obtained samples...
Abstract Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery brain from prior experience during wakefulness altered after acute SDS. However, effect SDS on sleep/wake behavior mice varies between studies. In addition, whether sleep changes response contribute not well established. Here, we first investigated effects states active period mice. Our results showed that total...
Background: There is wide heterogeneity in sepsis causative pathogens, host response, organ dysfunction, and outcomes. Clinical biologic phenotypes of are proposed, but the role pathogen data on classification unknown. Methods: We conducted a secondary analysis Recombinant Human Activated Protein C (rhAPC) Worldwide Evaluation Severe Sepsis (PROWESS) Study. used latent class (LCA) to identify using, (i) only clinical variables (“host model”) and, (ii) combining with microbiology (e.g., site...
To facilitate adeno-associated virus (AAV)-mediated gene therapy in China, we conducted a study on the distribution of AAV-neutralizing antibodies (NAbs) healthy subjects and patients with Duchenne muscular dystrophy (DMD)/Becker (BMD). A total 352 adult controls (ACs) from national multicenter study, 100 schoolchild (SCs), 281 DMD/BMD Peking Union Medical College Hospital were enrolled this study. Cell-based inhibition assays applied, serum samples demonstrating 50% infection considered...
Nω-nitro-L-arginine methyl ester (L-NAME), one of the synthetic L-arginine analogues with inhibitory effects nitric oxide (NO) synthesis, is now widely used to examine role NO in various organs. We and others demonstrated that long-term treatment L-NAME causes hypertension cardiovascular lesions (perivascular fibrosis medial thickening), especially at microvascular levels. However, convincing evidence still lacking these are solely mediated by inhibition synthesis endothelium-derived (EDNO)....
Abstract Rationale: Isolated splenic metastasis from colorectal cancer is very rare, as metastatic involving the spleen usually a manifestation of widely disseminated disease. Splenectomy best therapeutic option for this entity and probably only chance radical cure. Patient Concerns: A 73-year-old male presented with abdominal distension dark red bloody stool 6-month duration. Diagnoses: Synchronous isolated cancer. Interventions: Based on multidisciplinary team (MDT) mode, patient underwent...
Abstract Objective Postoperative bowel obstruction was one of the most severe complications in patients who received colorectal surgeries. This study aimed to explore risk factors early postoperative and construct a nomogram predict possibility occurrence. Methods The records 1437 underwent elective surgery Peking University People’s Hospital from 2015 2020 were retrospectively collected. Risk identified by logistic regression analysis then constructed. Bootstrap applied verify stability...
To investigate the role of cell adhesion molecules CD44v6 and CEA in occurrence, development, metastasis colorectal cancer (CRC). Materials methods: The expression 76 CRC tissues 43 normal colon was detected using an immunohistological technique. relationship between 2 molecules’ their pathologic characteristics, especially for metastasis, investigated. Furthermore, relevance also assessed. Results: Expression protein higher than paracarcinoma tissue mucosa (both P < 0.001). Positive...
Abstract Background Postoperative pulmonary complications (PPCs) seems to be high in patients undergoing pelvic and sacrum tumor resection assisted by abdominal aortic balloon occlusion. We hypothesized that the accumulative occlusion time (AOT) of may predictive PPCs. The objective study was identify influence AOT on Methods Retrospectively analyzed perioperative factors 584 who underwent our hospital from January 1, 2016 December 31, 2018. PPCs including suspected infection, atelectasis,...
Abstract Purpose The debate surrounding factors influencing postoperative flatus and defecation in patients undergoing colorectal resection prompted this study. Our objective was to identify independent risk develop prediction models for bowel function surgeries. Methods A retrospective analysis of medical records conducted who surgeries at Peking University People’s Hospital from January 2015 October 2021. Machine learning algorithms were employed construct the time first defecation....
Background Adequate bowel preparation is essential for successful colonoscopy and polypectomy procedures. However, a significant proportion of patients still exhibit suboptimal preparation, ranging from 18% to 35%. The effectiveness agents can be hampered by volume taste, adversely affecting patient compliance tolerance. Therefore, exploring strategies minimise laxative improve tolerance adherence imperative ensure optimal quality. Methods analysis This study two-arm, single-blinded,...