A5090425045- Lung Cancer Treatments and Mutations
- Intracranial Aneurysms: Treatment and Complications
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Actinomycetales infections and treatment
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Photodynamic Therapy Research Studies
- Neonatal Respiratory Health Research
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Medical Imaging and Pathology Studies
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Respiratory viral infections research
- Infectious Diseases and Tuberculosis
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
Peking University First Hospital
2010-2025
Peking University
2010-2025
Northwestern University
2018-2025
Chongqing Medical University
2007-2024
Second Affiliated Hospital of Chongqing Medical University
2007-2024
Dalian Medical University
2007-2024
China Medical University
2024
First Hospital of China Medical University
2024
Guangdong Pharmaceutical University
2023-2024
Children's Hospital of Fudan University
2024
The coronavirus 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has spread across the world and is responsible for over 1,686,267 deaths worldwide. Co-infection with influenza A virus (IFV-A) during upcoming flu season may complicate diagnosis treatment of COVID-19. Little known about epidemiology outcomes co-infection. Data 213 COVID-19 patients treated at Tongji Hospital in Wuhan from January 28, 2020 to March 24, were retrospectively analyzed....
Nirmatrelvir-ritonavir, also known as paxlovid, is a widely used antiviral drug against coronavirus disease 2019 (COVID-19). Azvudine, previously to treat human immunodeficiency virus-1, has been COVID-19 in China. However, only few clinical studies have evaluated the effects of azvudine. Additionally, comparing nirmatrelvir-ritonavir with azvudine limited number.We carried out retrospective case‒control analysis at Third People's Hospital Tibet Autonomous Region. Eighty-two eligible...
RNA interference is a promising therapy in glioma treatment. However, the application of has been limited by instability and lack tumor targeting. Here, we report novel DNA tetrahedron, which can effectively deliver small interfering to cells induce apoptosis. siRNA, that suppress expression survivin glioma, was loaded into tetrahedron (TDN). To enhance ability active targeting this nanoparticle, modified one side nanostructure with aptamer as1411 (As-TDN-R), selectively recognize nucleolin...
Background Glioma is one of the most common, primary, and lethal adult brain tumors because its extreme aggressiveness poor prognosis. Several recent studies relevant to immune function CD44, a transmembrane glycoprotein as significant hyaluronic acid receptor, have achieved great success, revealing critical role CD44 in infiltration gliomas. The overexpression has been verified correlate with cancer migration, while clinical features expression not yet thoroughly characterized Methods...
In the phase 3 FLAURA trial, osimertinib was compared with first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as a first-line treatment for EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib showed longer progression-free survival (PFS), overall (OS), and similar safety profile. However, more studies demonstrating effectiveness of strategy are needed in real-world populations.We enrolled 1,556 patients EGFR-mutated stage IIIc-IV NSCLC from...
The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the long-term exposure traffic-related air function, airway inflammation, and respiratory symptoms.We enrolled 1003 residents aged 57.96 ± 8.99 years living Shichahai Community Beijing. Distances between home addresses nearest major roads were measured calculate home-road distance. used distance categories 1, 2, 3, representing <100 m, 100-200 >200 respectively, as dose indicator...
Immune-nutritional status is correlated with a clinical outcome in critical illness. Recently, controlling nutritional (CONUT) score and prognostic nutrition index (PNI) has been reported to predict prognosis following cancer other diseases. The aim of this study was explore the relationship between CONUT PNI 6-month patients severe traumatic brain injury (STBI).We retrospectively analyzed data 78 STBI, including PNI. Patients were divided into high group low group. also respectively....
Abstract Background Scarring central airway stenosis (SCAS) is a potentially life-threatening condition with debilitating symptoms. Interventional bronchoscopy increasingly used to relieve symptoms in patients SCAS, but recurrent frequently observed. Little data exist on the long-term prognosis of interventional for SCAS. We aimed assess prognostic factors bronchoscopic interventions SCAS optimize treatment. Methods This was retrospective study that enrolled 119 consecutive from January 2010...
A therapeutic option for advanced non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance is a clinical challenge. The outcomes of pembrolizumab in those inconclusive. Cytokine release syndrome (CRS) rarely reported immune-related adverse event the field immune checkpoint inhibitors therapy, raising challenges given paucity data such presentations. We present unique case 67-year-old female EGFR-mutated NSCLC who...
Severe and critical coronavirus pneumonia 2019 (COVID-19) often occurs in elder patients with multiple comorbidities, severe hypoxemia events constitute a key factor for the deterioration of some cases. The type COVID-19 could progress into acute respiratory distress syndrome multi-organ dysfunction, which are major causes death. Early non-invasive ventilation (NIV) treatment possible pathophysiological abnormalities is helpful to improve prognosis. Close monitoring oxygenation, reducing...
For lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) sensitive mutation and synchronous brain metastasis (syn-BM), when how to apply radiotherapy (RT) during first-line tyrosine kinase inhibitor (TKI) treatment remains debatable.From a real-world multicenter database, EGFR-mutant syn-BM diagnosed between 2010-2020 treated TKIs were enrolled divided into upfront TKI + RT groups. Median intracranial progression-free survival (mIC-PFS), median overall (mOS), their risk...
We present a structured light system to dynamically measure human chest wall motion for respiratory volume estimation. Based on projection of an encoded color pattern and few active markers attached the trunk, volumes are obtained by evaluating 3-D topographic changes in anatomically consistent measuring region during respiration. Three setups established: single-sided illuminating-recording setup standing posture, inclined supine double-sided posture. Results compared with pneumotachography...
Background Intravenous infusion of Endostar for three to four hours per day 14 days reduces patient compliance and affects quality life. Continuous intravenous (CI) represents a novel method administration; however, it is unclear whether effective safe when compared the traditional method. Methods We retrospectively reviewed patients with advanced non‐small cell lung cancer (NSCLC) administered CI (20 patients) or intermittent (II, 49 combined first‐line chemotherapy. Three in II group...
Abstract Anaplastic lymphoma kinase (ALK) rearrangements are drivers of a subset non‐small cell lung cancer (NSCLC). The rapid progression ALK inhibitors has significantly prolonged the progression‐free survival patients with gene‐sensitive mutations. However, response rare to tyrosine remains unknown. Here, we report case striatin (STRN)‐ALK‐positive NSCLC showing primary resistance first‐line therapy alectinib and limited clinical activity crizotinib in alectinib‐resistant setting.
Abstract Background Photodynamic therapy (PDT) is a promising interventional treatment approach that contributes to antitumor immunity. It has been reported PDT can enhance the effectiveness of immune checkpoint inhibitors (ICIs), but its mechanism yet unclear. Herein, we implemented bioinformatics analysis detect common pathways and potential biomarkers in non-small cell lung cancer (NSCLC), PDT, NSCLC immunotherapy investigate links between NSCLC, their clinical impact. Methods...
Immune checkpoint inhibitors (ICIs) across multiple treatment lines have not yet been evaluated comprehensively. The purpose of this research was to investigate whether or continuous cross-line ICIs therapy is effective in treating non-small cell lung cancer (NSCLC).
Recently, five novel single nucleotide polymorphisms (SNPs), rs10937625 in STK32B (serine/threonine kinase 32B), rs17590046 PPARGC1A (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), and rs12764057, rs10822974, rs7903491 CTNNA3 (catenin alpha 3), were found to be associated with increased risk of essential tremor (ET) a genome-wide association study (GWAS)in individuals Caucasian ancestry. Considering the overlap between ET Parkinson's disease (PD) pathological features...