A5007336405- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- interferon and immune responses
- Chemokine receptors and signaling
- Musculoskeletal synovial abnormalities and treatments
- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Management of metastatic bone disease
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Soft tissue tumor case studies
- Orthopedic Infections and Treatments
- Vascular Tumors and Angiosarcomas
- Peptidase Inhibition and Analysis
- Shoulder and Clavicle Injuries
- Neurofibromatosis and Schwannoma Cases
- Cardiac tumors and thrombi
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Colorectal and Anal Carcinomas
- Immune cells in cancer
Second Affiliated Hospital of Zhejiang University
2016-2025
Zhejiang Lab
2021-2025
Zhejiang University
2009-2025
Zhejiang University Medical College Affiliated Stomatological Hospital
2018-2025
Peking University First Hospital
2013-2021
Peking University
2013-2021
Breast Center
2020
Clinical Orthopaedics and Related Research
2018
Virginia Oncology Associates
2011-2012
Dana-Farber Cancer Institute
2011-2012
The poor 5-year survival rate in high-grade osteosarcoma (HOS) has not been increased significantly over the past 30 years. This work aimed to develop a radiomics nomogram for prediction at time of diagnosis HOS.In this retrospective study, an initial cohort 102 HOS patients, diagnosed from January 2008 March 2011, was used as training cohort. Radiomics features were extracted pretreatment diagnostic computed tomography images. A signature constructed with lasso algorithm; then, score...
Abstract The mechanism by which osteosarcomas metastasize is elusive, and challenges remain regarding its treatment with modalities including immunotherapy. CXCL12 deeply involved in the process of tumor metastasis T-cell homing, driven a chemokine gradient, but healthy bones are supposed to preferentially express CXCL12. Here, we show for first time that epigenetically downregulate expression via DNA methyltransferase 1 (DNMT1) consequently acquire ability impair cytotoxic homing site....
Abstract Precise timing of macrophage polarization plays a pivotal role in immunomodulation tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti‐inflammatory and regenerative effects while the essential proinflammatory M1 phenotype early inflammation stage is largely underestimated. Herein, superparamagnetic hydrogel capable timely controlling constructed by grafting nanoparticles collagen nanofibers. The magnetic responsive network enables efficient...
Osteosarcoma is the most prevalent malignant bone tumour with a poor prognosis. Shikonin (SHK) derived from traditional Chinese medicine Lithospermum that has been extensively studied for its notable anti-tumour effects, including osteosarcoma. However, application certain limitations. Valproic acid (VPA) histone deacetylase inhibitor (HDACI) recently employed as an adjunctive therapeutic agent allows chromatin to assume more relaxed state, thereby enhancing efficacy. This study was aimed...
Abstract Purpose: Standard treatment for patients with unresectable locally advanced or metastatic soft-tissue sarcoma (LA/M STS) is chemotherapy based on anthracyclines, but patient tolerance of limited. The present trial (NCT03792542) investigated the use anlotinib as first-line STS, in particular liposarcoma. Patients and Methods: Eligible were previously untreated, pathologically confirmed, LA/M STS cases. Anlotinib was given orally at a dose 12 mg once daily from days 1 to 14 every 3...
Purpose: Chondrosarcoma with metastatic disease has a very poor prognosis. However, the prognosis and potential prognostic factors of patients primary chondrosarcoma bone metastasis at presentation have not been documented because its rarity. Therefore, we examined this special cohort identify possible factors. Methods: The Surveillance, Epidemiology, End Results (SEER) program database was used to diagnosis from 2000 2013. analysis performed using Kaplan-Meier method Cox proportional...
There is a paucity of literature about prognostic evaluation for patients with breast cancer (BC) and bone metastasis at presentation. To date, little known how to accurately predict the prognosis BC Thus, an accurate prediction tool in this population urgently needed. Our goal construct novel nomograms presentation.We searched Surveillance, Epidemiology, End Results (SEER) database presentation between 2010 2016. Multivariate analysis was performed obtain significantly independent...
Purpose: Older osteosarcoma patients have a very poor prognosis and treatment for them remains challenge. The outcomes potential prognostic factors of primary or secondary older are rarely documented. Therefore, we examined the two special cohorts to identify possible factors, provide optimal strategy them. Methods: Surveillance, Epidemiology, End Results (SEER) program database was used aged over 40 years from 1973 2015. analysis performed using Kaplan-Meier method Cox proportional hazards...
Abstract Background The recent development of antibodies specific for the major hotspot mutations in epidermal growth factor receptor (EGFR), L858R and E746_A750del, may provide an opportunity to use immunohistochemistry (IHC) as a screening test EGFR gene mutations. This study was designed optimize IHC protocol criteria interpretation results using DNA sequencing gold-standard. Methods Tumor sections from fifty lung adenocarcinoma specimens Chinese patients were immunostained...
Abstract Kinase fusions represent an important type of somatic alterations that promote oncogenesis and serve as diagnostic markers in lung cancer. We aimed to identify the landscape clinically relevant kinase Chinese cancer explore rare rearrangements; thus, providing valuable evidence for therapeutic decision making. performed genomic profiling 425 cancer-relevant genes from tumor/plasma biopsies a total 17,442 patients using next generation sequencing (NGS). Patients’ clinical...
Aims Osseous invasion exhibited in soft-tissue sarcoma (STS) is recognized as a prognostic risk factor. Achieving wide margin the default surgical approach for local control. However, STSs where tumour contact with adjacent cortex but without clear evidence of osseous invasion, such medullary question whether bone resection can provide better control or survival than more conservative sub-periosteal excision remains controversial. The aim this study was to assess thigh STS cortical results...
Sensory innervation triggers the regenerative response after injury. However, dysfunction and impairment of sensory nerves, accompanied by excessive inflammation impede tissue regeneration. Consequently, specific induction to mediate immunoregulation becomes a promising therapeutic approach. Herein, we developed cell/drug-free strategy selectively boost endogenous harness immune responses for promoting rehabilitation. Specifically, dual-functional phage was constructed with nerve–homing...
This study aims to investigate the feasibility and oncological outcomes of vessel-sparing surgery for soft tissue sarcomas located near femoral vessels in thigh. A comparison was made with cases where tumor not adjacent vessels, focusing on recurrence rates, survival prognosis, viability surgical techniques. retrospective analysis conducted 211 cases. After well-differentiated liposarcoma were excluded from further analysis, 148 involved tumors while 22 vessels. Postoperative functional...
To review the clinical details and further treatments for recurrent spinal giant cell tumors (SGCT), to analyze risk factors of recurrence shed new light on treatment options prognosis SGCT.A retrospective analysis SGCT between April 2003 January 2014 was performed. A total 10 patients comprising 3 men 7 women with a mean age 28.9 years (range, 21-40 years) were included in study. All complete data, radiographs, CT, MRI, scans pathological data reviewed. The tumor locations regions involved...
Primary bone sarcomas of the hands or feet are rare lesions and poorly documented. Moreover, prognostic determinants have not been reported.The Surveillance, Epidemiology, End Results (SEER) program database was used to screen patients with from 1973 2013, attention paid chondrosarcoma, Ewing sarcoma, osteosarcoma. The values overall survival (OS) cancer-specific (CSS) were assessed using Cox proportional hazards regression model univariate multivariate analyses. Kaplan-Meier method obtain...
Roughly 30-40% of lung cancer (LC) patients develop bone metastasis during the course disease. The genetic differences between primary LC and matched are not yet fully understood.A total 40 with were collected 450 targeted cancer-related genes sequenced for genomic-alteration (GA) identification.Among patients, 33 had adenocarcinomas 7 squamous cell carcinomas. metastatic sites (LUADs) pelvis (6 patients), spine (16 limbs (11 patients). A 425 422 GAs detected in lesions, respectively. most...
Human Vγ9Vδ2 T cells have attracted considerable attention as novel alternative antigen-presenting (APCs) with the potential to replace dendritic in antitumor immunotherapy owing their high proliferative capacity and low cost. However, utility of γδ APCs induce CD8+ cell-mediated immune response, well mechanism by which they perform APC functions, remains unexplored. In this study, we found that activated were capable inducing robust cell responses osteosarcoma cells. Activated also...
The long term survival of osteosarcoma has remained unchanged in the last several decades. Immunotherapy is proved to be a promising therapeutic strategy against osteosarcoma, especially for those with metastasis. Our previous study explored sensibilization zoledronate (ZOL) γδ T cell-mediated cytotoxicity but we haven't yet elucidated specific mechanism. Besides, high concentration required achieve these effects, whereas plasma ZOL declines rapidly circulation. Valproic acid (VPA), histone...
This study was performed to explore the clinical efficacy of bone transport using external fixation for treatment large defects after tibial tumor resection in five patients. Bone started 14 days postoperatively at 1 mm/day and adjusted according callus-to-diameter ratio. The time, graft fusion, relapse, metastasis were recorded. Clinical evaluated Musculoskeletal Tumor Society (MSTS) scoring system. tumors included osteosarcoma (n=2), Ewing sarcoma (n=1), malignant schwannoma hemangioma...
In this study, we present a novel coating with Zn-releasing ability that promotes osseointegration of Ti6Al4V implants. The coatings were prepared by sol–gel technique, and nanosized Zn-containing β-tricalcium phosphate particles added to the Ca(NO3)2–P2O5–HPF6 sol system incorporate Zn ions into fluoridated hydroxyapatite (FHA) coatings. derived (ZTFHA) demonstrated slow sustained release behavior. ZTFHA able support cell growth osteoblast-like cultures promoted an obvious increase in...
Sacral schwannoma is relatively rare and both the early diagnosis appropriate treatment of sacral schwannomas are equally very challenging.11 cases operated at Second Affiliated Hospital, School Medicine, Zhejiang University, from 2012 to 2016, were investigated retrospectively 10 followed up. All patients assessed with X-ray, CT MRI, underwent an intralesional excision.One patient was male, nine female average age 48 (ranging between 31 63). Three suffered back leg pain, seven had no...