A5100446648- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Immune cells in cancer
- interferon and immune responses
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Psoriasis: Treatment and Pathogenesis
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Nanoplatforms for cancer theranostics
- Bladder and Urothelial Cancer Treatments
- IL-33, ST2, and ILC Pathways
- Bone Metabolism and Diseases
- Dermatology and Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
Zhejiang University
2016-2025
Zhejiang Center for Disease Control and Prevention
2021-2025
Peking University First Hospital
2022-2025
Peking University
2022-2025
Anhui Medical University
2025
Stomatology Hospital
2025
Harbin Engineering University
2025
The University of Western Australia
2020-2024
Sir Run Run Shaw Hospital
2008-2024
Shanghai University
2024
Abstract Myeloid-derived suppressor cells (MDSCs) potently suppress the anti-tumor immune responses and also orchestrate tumor microenvironment that favors angiogenesis metastasis. The molecular networks regulating accumulation functions of tumor-expanded MDSCs are largely unknown. In this study, we identified microRNA-494 (miR-494), whose expression was dramatically induced by tumor-derived factors, as an essential player in activity targeting phosphatase tensin homolog (PTEN) activation...
MicroRNAs are small non-coding RNA molecules that regulate gene expression by either translational inhibition or mRNA degradation. play pivotal roles in the regulation of both innate and adaptive immune responses, including TLR-triggered inflammatory response. Here we reported microRNA-223 (miR-223) was significantly decreased murine macrophages during activation lipopolysaccharide (LPS) poly (I∶C) stimulation. The inducible miR-223 down-regulation resulted signal transducer activator...
Abstract Metabolite alteration has been associated with the pathogenesis of inflammatory bowel disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is involved in metabolism and synthesis glycoproteins, exhibits anti-inflammatory anti-oxidative activities. We show here circulating level mannose increased patients IBD mice experimental Mannose treatment attenuates intestinal barrier damage two mouse colitis models, dextran sodium sulfate (DSS)-induced spontaneous...
Although certain therapeutic agents with immunogenic properties may enhance antitumor immunity, cancer cells can eliminate harmful cytoplasmic entities and escape immunosurveillance by orchestrating autophagy. Here, an ingenious in situ self-assembled nanomicelle dissolving microneedle (DMN) patch was designed for intralesional delivery of cell death-inducer (IR780) autophagy inhibitor (chloroquine, CQ) coencapsulated micelles (C/I-Mil) efficient therapy. Upon insertion into skin, the...
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine that crucial for dampening the inflammatory response after pathogen invasion, and was found to be produced by macrophages exposure lipopolysaccharide (LPS). It remains unclear whether microRNA-mediated regulatory mechanism involved in LPS-induced IL-10 production. Here we reported miR-98 expression significantly decreased following LPS stimulation. We also targets 3'untranslated region of transcript. Overexpression inhibited...
NK cells are important innate immune with potent cytotoxicity that can be activated by type I IFN from the host once infected. How cell is and then tightly regulated remain to fully elucidated. MicroRNAs (miRNAs, or miRs) regulators of response, but full scale miRNome in human remains determined. In this study, we reported an in-depth analysis miRNomes resting IFN-α-activated cells, found two abundant miRNAs, miR-378 miR-30e, markedly decreased IFN-α, further proved miR-30e directly targeted...
Resident and inflammatory mononuclear phagocytes (MPhs) with functional plasticity in the intestine are critically involved pathology of bowel diseases (IBDs), mechanism which remains incompletely understood. In present study, we found that increased expression E3 ligase F-box WD repeat domain–containing 7 (FBXW) inflamed was significantly correlated IBD severity both human mouse models. Myeloid Fbxw7 deficiency protected mice from colitis induced by dextran sodium sulfate (DSS) or...
Serum levels of miR-194 have been reported to predict prostate cancer recurrence after surgery, but its functional contributions this disease not studied. Herein, it is demonstrated that a driver metastasis. Prostate tissue were associated with aggressiveness and poor outcome. Ectopic delivery stimulated migration, invasion, epithelial-mesenchymal transition in human cell lines, stable overexpression enhanced metastasis intravenous intraprostatic tumor xenografts. Conversely, inhibition...
Tumor-induced, myeloid-derived suppressor cells (MDSCs)-mediated immune dysfunction is an important mechanism that leads to tumor escape and the inefficacy of cancer immunotherapy. Importantly, tumor-infiltrating MDSCs have much stronger ability compared in periphery. However, mechanisms microenvironment induces accumulation function are poorly understood. Here, we report Interleukin-33 (IL-33) - a cytokine which can be abundantly released tissues both 4T1-bearing mice breast patients,...
Proper selection and effective delivery of combination drugs targeting multiple pathophysiological pathways key to spinal cord injury (SCI) hold promise address the thus far scarce clinical therapeutics for improving recovery after SCI. In this study, we aim develop a clinically feasible way targeted with different physiochemical properties SCI site, detail underlying mechanism neural recovery, detect any synergistic effect related therapy. Methods: Liposomes (LIP) modified scar-targeted...
Abstract To improve the efficiency and application prospects of metal peroxides in tumor therapy, synthesis bimetallic via simple yet effective approaches will be highly significant. In this work, hyaluronic acid modified zinc‐copper (ZCPO@HA) nanoparticles are synthesized through a one‐step symbiotic method by co‐hydrolysis zinc acetate copper weakly alkaline solution, followed modification with sodium hyaluronate. Upon decomposition microenvironment, ZCPO@HA can generate considerable...
The NLRP3 inflammasome is the most characterized activated by cellular infection or stress, which responsible for maturation of proinflammatory cytokines IL-1β and IL-18. precise molecular mechanism negative regulation activation needs to be further defined. Here we identify leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) as an NLRP3-associated inhibitor activation. LRRFIP2 binds via its N terminus upon activation, also interacts with Flightless-I, a pseudosubstrate caspase-1, Coil...
Protein ubiquitination regulated by ubiquitin ligases plays important roles in innate immunity. However, key regulators of during response and new types (apart from Lys48- Lys63-linkage) control signaling have not been clearly understood. Here we report that F-box only protein Fbxo21, a functionally unknown component SCF (Skp1–Cul1–F-box protein) complex, facilitates Lys29-linkage activation ASK1 (apoptosis signal-regulating kinase 1), promotes type I interferon production upon viral...
Parkinson's disease (PD) is the second most common neurodegenerative in world; however, it lacks effective and safe treatments. Ginkgo biloba dropping pill (GBDP), a unique Chinese G. leaf extract preparation, exhibits antioxidant neuroprotective effects has potential as an alternative therapy for PD. Thus, aims of this study were to evaluate GBDP vitro vivo PD models compare chemical constituents pharmacological activities EGb 761. Using liquid chromatography tandem-mass spectrometry, 46...
Kai-Xin-San (KXS) is a traditional Chinese medicinal formula composed of Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii and Poria for relieving major depressive disorder Alzheimer’s disease in medicine (TCM) clinics. Previous studies on the antidepressant mechanism KXS mainly focused neurotransmitter neurotrophic factor regulation, but few reports exist neuronal inflammation regulation. In current study, we found that exerted effects chronic unpredictable mild stress-induced...