A5078170751- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Neutropenia and Cancer Infections
- Nausea and vomiting management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Stress Responses and Cortisol
Xuzhou Medical College
2016-2025
Soochow University
2025
Tongde Hospital of Zhejiang Province
2025
Ludong University
2025
Xinjiang University
2025
Weihai Maternal and Child Health Hospital
2025
Affiliated Hospital of Xuzhou Medical College
2012-2024
Fuyang City People's Hospital
2024
Cancer Hospital of Chinese Academy of Medical Sciences
2023
University of Chinese Academy of Sciences
2023
Background/Aims: Targeting cancer stem cells (CSCs) is emerging as a promising method for treatment. We previously indicated that knockdown of Neuropilin 1(NRP-1) could inhibit breast cell proliferation. Here, we continue exploring the roles and mechanisms VEGF-A/NRP-1 axis in CSCs formation. Methods: qRT-PCR was used to detect levels VEGF-A NRP-1 sphere wild-type cells. Mammospheres formation, flow cytometry, soft agar colony tumor formation assays were performed evaluate effects on...
Kai-Xin-San (KXS) is a traditional Chinese medicinal formula composed of Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii and Poria for relieving major depressive disorder Alzheimer’s disease in medicine (TCM) clinics. Previous studies on the antidepressant mechanism KXS mainly focused neurotransmitter neurotrophic factor regulation, but few reports exist neuronal inflammation regulation. In current study, we found that exerted effects chronic unpredictable mild stress-induced...
Advanced hepatocellular carcinoma (HCC) is a severe malignancy that poses serious threat to human health. Owing challenges in early diagnosis, most patients lose the opportunity for radical treatment when diagnosed. Nonetheless, recent advancements cancer immunotherapy provide new directions of HCC. For instance, monoclonal antibodies against immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1/death ligand-1 and cytotoxic t-lymphocyte associated antigen-4...
Others and ours studies have established the promoting roles of NRP-1 (neuropilin-1) in breast cancer, however, underlying mechanisms by which is regulated are still confused. Here, bioinformatics analysis indicated that RNA binding protein PUM2 could bind to mRNA. Clinical samples showed expression was significantly increased cancer tissues, negatively correlated with overall survival relapse-free patients, positively expression. Meanwhile, remarkably non-adherent spheroids. vitro...
Gastric cancer (GC) is the fifth most common malignancy and third leading cause of death worldwide. Despite advancements in immunotherapies, patient prognosis remains poor, necessitating identification key prognostic factors to optimize treatment approaches. Insulin resistance, as indicated by triglyceride glucose (TyG) index, increasingly recognized for its impact on progression immune modulation, potential role GC particular interest. To investigate whether TyG a surrogate marker insulin...
RNA degradation using ribonuclease targeting chimeras (RiboTACs) is a promising approach for cancer therapy. However, potential off-target serious issue. Here, RiboTAC designed tumor microenvironment triggered activation. The activated (TaRiboTAC) incorporates two pre-miR-21 binders, near-infrared fluorophore IR780, an RGD peptide and phenylboronic acid caged recruiter. recruiter embedded in the molecule exposed acidic pH, cage removed by H2O2 making TaRiboTAC responsive to high levels...
The roles and related mechanism of miR-376a in breast cancer cell progression are unclear.Kaplan-Meier plotter analysis was used to analyze the correlation between overall survival (OS) patients. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) performed detect level cells. Cell viability, transwell migration invasion, apoptosis were constructed investigate effects on Luciferase reporter RNA immunoprecipitation (RIP) explore targeting NRP-1.miR-376a expression...
HER2-positive breast cancer was aggressive, resulting in a poorer prognosis. This multicenter study analyzed the real-world data of women treated with pyrotinib-based therapy, aiming to describe their characteristics, treatment regimens, and investigate clinical outcomes.A total 141 patients were enrolled from February 2019 April 2020. Last follow-up time 2021. All therapy 21-day cycles. The primary endpoint progression-free survival (PFS).The median PFS (mPFS) for 12.0 months (95%CI...
Aims: To compare the effectiveness and safety of transarterial chemoembolization (TACE) combined with apatinib plus camrelizumab (TACE+AC) versus TACE alone (TACE+A) for patients advanced HBV-related hepatocellular carcinoma (HBV–HCC).
 Methods: The clinical data HBV–HCC who received either TACE+AC or TACE+A treatment were retrospectively analyzed. Overall survival (OS), progression-free (PFS), objective response rate (ORR), disease control (DCR), adverse events (AEs) compared between...
Background: Breast cancer (BC) is the most prevalent solid affecting women's health globally.Matrine (MAT), a traditional Chinese herb, has exhibited antitumor effects against BC.However, its mechanism of action, particularly whether it involves control cell proliferation and epithelial-mesenchymal transition (EMT), remains unknown. Aims:To explore MAT's role in BC regulatory mechanisms, as well to identify targets for development novel medicines improvement treatment modalities.Study...
Introduction: Immunotherapy targeting PD-1/PD-L1 shows significant benefits in lung cancer. Cutaneous immune-related adverse events (irAEs) are frequent, early-developing side effects of ICIs, and their potential role as prognostic markers non-small cell cancer (NSCLC) therapy requires further exploration. Methods: Data patients with NSCLC treated camrelizumab Combined chemotherapy were collected at Xuzhou Medical University from 2019 to 2023. irAEs monitored using CTCAE v5.0, therapeutic...
With China becoming an aging society, the number of elderly care institutions (ECIs) is continuously increasing in response to growing population older persons. However, regional disparities may lead uneven distribution ECIs, which could affect equity care. This study identified limiting factors development ECIs across different regions, thereby promoting accessing for population. utilised point-of-interest data on from 2018 2022. The spatiotemporal and causes were assessed along four...
<title>Abstract</title> <bold>Background</bold> As a cell adhesion factor, cluster of differentiation 99 (CD99) mainly plays role in regulating differentiation. Recent studies have revealed an important for CD99 the initiation and progression several cancers. However, comprehensive pan-cancer analysis has not been performed. <bold>Methods</bold> In this study, we utilized advanced bioinformatics techniques to conduct in-depth investigation expression across diverse tumors, its prognostic...
This study investigates efficient dehydration and solidification techniques for waste mud generated from loess pile foundations during highway construction in Lanzhou, Northwest China. The mud, characterized by high viscosity (85% moisture content) alkalinity (pH 11.2), poses environmental risks if untreated. Dehydration experiments identified an optimal composite flocculant mixture of 3.5 g polyaluminum chloride (PAC) 22 mL anionic polyacrylamide (APAM) per 500 accelerating sedimentation...
This study focuses on Neogene red-bed soft rock tunnels in the Huicheng Basin, China. Through engineering geological investigation, remote wireless monitoring systems, and total station multi-parameter monitoring, deformation characteristics of surrounding under high situ stress environments their influencing factors were systematically analyzed. The findings reveal that follows a three-stage evolutionary pattern “rapid, slow, stable”. Construction disturbances can disrupt stable state,...
6038 Background: For patients with unresectable recurrent or metastatic solid tumors that progress after chemotherapy, immune checkpoint inhibitors (ICIs), targeted therapy, treatment options are limited. GT201, featuring membrane-bound IL-15 (mbIL-15) expressed on TILs, aims to enhance activation in the tumor microenvironment and may demonstrate efficacy durable responses these advanced cases. We present data from nine enrolled open-label, single-arm studies investigate safety trends of...
5613 Background: Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TILs) has shown promising results in melanoma patients. However, its effectiveness other solid tumors, especially "cold" is still being explored. GT300, a next-generation TIL product, engineered CRISPR/AaCas12bMax to disrupt two key immunoregulatory targets identified through genome-wide CRISPR screening. This modification aims enhance function and overcome the suppressive tumor microenvironment,...
e13016 Background: Pyrotinib is an irreversible tyrosine kinase inhibitor that inhibits EGFR, HER2, and HER4. Multiple studies have demonstrated the efficacy safety of pyrotinib in HER2-positive advanced breast cancer. The phase 3 PHILA study combined with trastuzumab chemotherapy achieved promising first-line treatment Here we supplemented real-world evidence on use pyrotinib. Methods: PRETTY was a nationwide, prospective observational conducted at 61 sites China from August 2019 to...
Gastric cancer (GC), a leading cause of mortality, exhibits profound molecular heterogeneity and immunosuppressive tumor microenvironment (TME) features that limit therapeutic efficacy. This review elucidates the dual roles tertiary lymphoid structures (TLS) tumor-infiltrating lymphocytes (TILs) in GC progression. TLS, ectopic organs formed under chronic inflammation, correlate with improved survival immunotherapy sensitivity by fostering effector T/B cell interactions antigen presentation....