A5100783587- Cancer Research and Treatments
- Inflammasome and immune disorders
- Sulfur Compounds in Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Heme Oxygenase-1 and Carbon Monoxide
- NF-κB Signaling Pathways
- Biochemical effects in animals
- Medical Imaging Techniques and Applications
- Galectins and Cancer Biology
- Radiopharmaceutical Chemistry and Applications
- Molecular Sensors and Ion Detection
- Ubiquitin and proteasome pathways
- Neurological Disease Mechanisms and Treatments
- Advanced Nanomaterials in Catalysis
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Acupuncture Treatment Research Studies
- Paraoxonase enzyme and polymorphisms
- Traditional and Medicinal Uses of Annonaceae
- Medicinal Plants and Neuroprotection
- Cholesterol and Lipid Metabolism
- Plant Stress Responses and Tolerance
- Neuroendocrine regulation and behavior
- Spinal Fractures and Fixation Techniques
Shanghai Medical College of Fudan University
2023
Xi'an Medical University
2020
Air Force Medical University
2015-2020
Anhui Medical University
2020
First Affiliated Hospital of Anhui Medical University
2020
China Pharmaceutical University
2014-2019
Boston College
2016
Peking University First Hospital
2015
Peking University
2015
Columbia University
2014
When innate immune cells such as macrophages are challenged with environmental stresses or infection by pathogens, they trigger the rapid assembly of multi-protein complexes called inflammasomes that responsible for initiating pro-inflammatory responses and a form cell death termed pyroptosis. We describe here identification an intracellular NLRP3-mediated inflammatory signaling, IL-1β production pyroptosis in primed murine bone marrow-derived is mediated disruption glycolytic flux. This...
Abstract Non-small cell lung cancer (NSCLC) is one of the most common malignancies in world. Although extensive studies showed that luteolin exhibited antitumor effects against NSCLC, mechanism has not been fully established. In present study, we found significantly reduced expression absent melanoma 2 (AIM2) at both mRNA and protein levels leading to suppression AIM2 inflammasome activation, which induced G2/M phase arrest inhibited epithelial–mesenchymal transition (EMT) NSCLC....
The NLRP3 inflammasome is the most characterized activated by cellular infection or stress, which responsible for maturation of proinflammatory cytokines IL-1β and IL-18. precise molecular mechanism negative regulation activation needs to be further defined. Here we identify leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) as an NLRP3-associated inhibitor activation. LRRFIP2 binds via its N terminus upon activation, also interacts with Flightless-I, a pseudosubstrate caspase-1, Coil...
Background/Aims: Stroke is among the top causes of death worldwide. Neuroprotective agents are thus considered as potentially powerful treatment stroke. Methods: Using both HT22 cells and male Sprague-Dawley rats in vitro vivo models, we investigated effect NaHS, an exogenous donor H2S, on focal cerebral ischemia-reperfusion (I/R) induced brain injury. Results: Administration NaHS significantly decreased infarcted area compared to I/R group a dose-dependent manner. Mechanistic studies...
Glycine decarboxylase complex (GDC) is a multi-protein complex, comprising P-, H-, T- and L-protein subunits, which plays major role in photorespiration plants. While structural analysis has demonstrated that the H subunit of GDC (GDCH) pivotal GDC, research on GDCH biological processes plants seldom reported. Here, function GDCH, stresses resulting from GDCH-knockdown interactions these with other cellular were studied rice Under high CO(2), OsGDCH RNA interference (OsGDCH-RNAi) grew...
<b><i>Background:</i></b> Inflammatory response exerts an important role in ischemia/reperfusion (I/R) injury. TLR4 and myeloid differentiation factor 88 (MyD88) are key components inflammation involved the cerebral I/R Irisin is a skeletal muscle-derived myokine produced after exercise, which was found to suppress inflammation. In this study, we investigated whether irisin could protect brain from injury through TLR4/MyD88 pathway....
MC13 is a novel coumarin compound found in Murraya, an economic crop whose leaves are widely used as condiment (curry) cuisine. The aims of the present study were to investigate neuroprotective effects on microglia-mediated inflammatory injury model well potential molecular mechanism. Cell viability and apoptosis assay demonstrated that was not toxic neurons significantly protected from upon lipopolysaccharide (LPS) stimulation. Results showed markedly inhibited LPS-induced production...
TNF receptor-associated factor 6 (TRAF6) is a key hub protein involved in Toll-like receptor-dependent inflammatory signaling pathway, and it recruits additional proteins to form multiprotein complexes capable of activating downstream NF-κB pathway. Ubiquitin-proteasome system (UPS) plays crucial role various degradations, such as TRAF6, leading inhibitory effects on response immunologic function. However, whether ubiquitination-dependent TRAF6 degradation can be used novel anti-inflammatory...
Phytochemical investigation of methanol extract from the spikes Prunella vulgaris L. led to isolation two new pentacyclic triterpenoid glycosides Vulgasides I (1) and II (2) along with 13 known compounds (3–15). Their structures were established on basis nuclear magnetic resonance (1D 2D) mass spectroscopic data analysis. All isolated screened for glycogen phosphorylase inhibitory activity also evaluated their effect insulin sensitivity in 3T3‐L1 adipocytes. Two (1, 2) did not demonstrate...
Ilex kudingcha C.J. Tseng (Kudingcha) is a traditional Chinese drink consumed in East Asia. The present study evaluated the vitro anticancer effects of Kudingcha MCF-7 human breast adenocarcinoma cells using 3-(4,5-dimethyl‑2-thiazolyl)‑2,5-diphenyltetrazolium bromide (MTT) assay. At concentration 200 µg/ml, inhibited growth by 81%. This was greater degree inhibition than that observed at concentrations 100 and 50 µg/ml (58 19%, respectively). To elucidate inhibitory mechanisms underlying...
Brain ischemia leads to poor oxygen supply, and is one of the leading causes brain damage and/or death. Neuroprotective agents are thus in great need for treatment purpose. Using both young aged primary cultured hippocampal neurons as vitro models, we investigated effect sodium hydrosulfide (NaHS), an exogenous donor hydrogen sulfide, on oxygen-glucose deprivation (OGD) damaged that mimick focal cerebral ischemia/reperfusion (I/R) induced injury. NaHS (250 μM) protected neurons, indicated by...
Although learning and memory decline are associated with aging, some older individuals show high cognitive function. The mechanism underlying successful aging is not clear, although augmented N-methyl-D-aspartate receptor-independent long-term depression (LTD) has been found in successfully aged rats. We hypothesized that metabotropic glutamate receptor dependent LTD (mGluR-LTD) mice explored its molecular mechanisms. divided into impaired unimpaired groups examined mGluR-LTD the...
Abstract Aberrant N-linked glycosylation is a prominent feature of cancers. Perturbance oligosaccharide structure on cell surfaces directly affects key processes in tumor development and progression. In spite the critical role played by glycans biology, discovery small molecules that specifically disturbs still under investigation. To identify more saccharide-structure-perturbing compounds, repurposed drug screen using library consisting 1530 FDA-approved drugs was performed. Interestingly,...
Background: Intracranial vertebral artery dissection aneurysms (VADAs) may cause acute ischemia or hemorrhage and the urgent endovascular treatment is needed. Although majority of patients obtained a good functional outcome after surgery, surprising finding was bad quality life (QOL) in follow-up. The purpose this study to evaluate clinical efficacy analyze contributing factors QOL reconstructive therapy for intracranial VADAs. Methods: In prospective study, 33 consecutive VADAs with...
<p>(a) Western blot analysis of protein expression pattern PD-L1 in HEK293T cells after the exposure to indicated concentrations penfluridol for 24 hours. (b) Protein B16-F10 treatment with 12 hours as determined by western blot. (c) The toxicity effect on (top) and B16-OVA (bottom) cells. (d) MAN1A1 treated siRNA.</p>
<p>(a) The stability of proteins was determined by cellular thermal shift at different concentrations penfluridol.</p>
<p>Supplementary Figure S1-S4 Supplementary Table S1</p>
<p>Supplementary Figure S1-S4 Supplementary Table S1</p>