A5054705832- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- Mental Health Treatment and Access
- Receptor Mechanisms and Signaling
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced MRI Techniques and Applications
- Electroconvulsive Therapy Studies
- Psychosomatic Disorders and Their Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Diet and metabolism studies
- Personality Disorders and Psychopathology
New York Psychoanalytic Society and Institute
2016-2025
Columbia University
2016-2025
Columbia University Irving Medical Center
2016-2025
New York State Psychiatric Institute
2015-2024
Janssen (United States)
2023
Icahn School of Medicine at Mount Sinai
2014-2023
Cornell University
1983-2021
Weill Cornell Medicine
2021
University Hospital and Clinics
2021
University Medical Center
2021
The Columbia–Suicide Severity Rating Scale was initially designed to assess suicidal ideation and behavior in clinical trials. Psychometric analysis of data on adolescents indicated that a lifetime history worst-point including either intent or with plan predicts future risk an actual attempt is four times as great the associated current ideation—including desire be dead—or increased general ratings depression.
The classical dopamine hypothesis of schizophrenia postulates a hyperactivity dopaminergic transmission at the D 2 receptor. We measured in vivo occupancy striatal receptors by 18 untreated patients with and matched controls, comparing receptor availability before during pharmacologically induced acute depletion. Acute depletion intrasynaptic resulted larger increase (19% ± 11%) compared control subjects (9% 7%, P = 0.003). increased occurred both first-episode neuroleptic-naive previously...
To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination generate mice lacking specific serotonergic receptor subtypes. In present report, demonstrate that without 5-HT1A display decreased exploratory activity and increased fear aversive environments (open or elevated spaces). knockout also exhibited a immobility in forced swim test, an effect commonly associated with antidepressant treatment....
ContextElectroconvulsive therapy (ECT) is highly effective for treatment of major depression, but naturalistic studies show a high rate relapse after discontinuation ECT.ObjectiveTo determine the efficacy continuation pharmacotherapy with nortriptyline hydrochloride or combination and lithium carbonate in preventing post-ECT relapse.DesignRandomized, double-blind, placebo-controlled trial conducted from 1993 to 1998, stratified by medication resistance presence psychotic depression index...
The authors investigated the predictive potential of a stress-diathesis model for suicidal behavior based on correlates past acts. In this model, acts are precipitated by stressors such as life events or major depressive episode in setting propensity acting urges. This diathesis is expressed tendency to develop more pessimism response stressor and/or presence aggressive/impulsive traits. was tested determining whether clinical predict during 2-year follow-up patients with episode.Patients...
Objective: In 2003 and 2004, U.S. European regulators issued public health warnings about a possible association between antidepressants suicidal thinking behavior. The authors assessed whether these discouraged use of in children adolescents they led to increases suicide rates as result untreated depression. Method: examined Dutch data on prescription for selective serotonin reuptake inhibitors (SSRIs) from 2005 (patients up age 19), well adolescents, using available (through 2004 the...
• A statistically significant 28% increase in the mean (±SD) number of serotonin<sub>2</sub>receptors (127.8±13.4 vs 99.6 ±11.1 fmol/mg protein) and a 73% β-adrenergic receptor binding (14.5±1.5 8.4 ±1.5 fmol/mg) was found frontal cortices violent suicide victims compared with matched controls. No differences were serotonin<sub>,</sub>binding sites (109.5 ± 13.4 99.9 ±8.8 fmol/mg). We have previously reported reduced density presynaptic tritiated imipramine on serotonergic nerve terminals...
Background: Recently discovered relationships between the gastrointestinal microbiome and brain have implications for psychiatric disorders, including major depressive disorder (MDD). Bacterial transplantation from MDD patients to rodents produces depression-like behaviors. In humans, case-control studies examined gut in healthy affected individuals. We systematically reviewed existing comparing microbial composition volunteers. Methods: A PubMed literature search combined terms...
OBJECTIVE: Suicidal behavior is highly prevalent in borderline personality disorder and major depressive episode, although the characteristics of suicide attempts two disorders are believed to differ. Comorbidity episode may obscure that uniquely related psychopathology each disorder. We compared suicidal patients with disorder, plus determine whether differed between groups if aspects core predicted specific attempt characteristics. METHOD: Eighty-one inpatients including 49 were 77 alone...
Few studies have investigated the association between religion and suicide either in terms of Durkheim's social integration hypothesis or regulative benefits religion. The relationship attempts has received even less attention.Depressed inpatients (N=371) who reported belonging to one specific described themselves as having no religious affiliation were compared their demographic clinical characteristics.Religiously unaffiliated subjects had significantly more lifetime first-degree relatives...