A5025960711- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Opioid Use Disorder Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Causal Inference Techniques
- Alcohol Consumption and Health Effects
- Smoking Behavior and Cessation
- Mental Health Research Topics
- Homelessness and Social Issues
- Schizophrenia research and treatment
- Statistical Methods and Bayesian Inference
- Behavioral Health and Interventions
- Statistical Methods in Clinical Trials
- Prenatal Substance Exposure Effects
- Functional Brain Connectivity Studies
- Cannabis and Cannabinoid Research
- Attention Deficit Hyperactivity Disorder
- Treatment of Major Depression
- Suicide and Self-Harm Studies
- Digital Mental Health Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Inference
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
University of Pennsylvania
2016-2025
Philadelphia VA Medical Center
2008-2025
Mental Illness Research, Education and Clinical Centers
2010-2025
United States Department of Veterans Affairs
2004-2025
VA Western New York Healthcare System
2025
VA Pittsburgh Healthcare System
2025
VA Connecticut Healthcare System
2025
Center for Clinical Research (United States)
2019-2024
AtlantiCare
2023
Trinity College Dublin
2022-2023
OBJECTIVE: Suicidal behavior is highly prevalent in borderline personality disorder and major depressive episode, although the characteristics of suicide attempts two disorders are believed to differ. Comorbidity episode may obscure that uniquely related psychopathology each disorder. We compared suicidal patients with disorder, plus determine whether differed between groups if aspects core predicted specific attempt characteristics. METHOD: Eighty-one inpatients including 49 were 77 alone...
<h3>Context</h3>The usual treatment for opioid-addicted youth is detoxification and counseling. Extended medication-assisted therapy may be more helpful.<h3>Objective</h3>To evaluate the efficacy of continuing buprenorphine-naloxone 12 weeks vs youth.<h3>Design, Setting, Patients</h3>Clinical trial at 6 community programs from July 2003 to December 2006 including 152 patients aged 15 21 years who were randomized or a 14-day taper (detox).<h3>Interventions</h3>Patients in 12-week group...
<h3>Importance</h3> Selecting effective antidepressants for the treatment of major depressive disorder (MDD) is an imprecise practice, with remission rates about 30% at initial treatment. <h3>Objective</h3> To determine whether pharmacogenomic testing affects antidepressant medication selection and such leads to better clinical outcomes. <h3>Design, Setting, Participants</h3> A pragmatic, randomized trial that compared guided by vs usual care. Participants included 676 clinicians 1944...
Abstract Social scientists are commonly interested in relating a latent trait (e.g., criminal tendency) to measurable individual covariates poor parenting) understand what defines or perhaps causes the trait. In this article we develop an efficient and convenient method for answering such questions. The basic model presumes that two types of variables have been measured: Response (possibly longitudinal) partially determine class membership, risk factors wish relate these variables. assumes...
A childhood history of sexual or physical abuse is highly prevalent in borderline personality disorder (BPD) and associated with self-destructive behavior clinical nonclinical samples. Viewing BPD as a “high risk” disorder, we asked if was risk factor for adult suicidal it related to other known factors suicide BPD. semistructured Abuse History obtained 61 criteria-defined patients, who were characterized by structured interviews self-reports Axis I disorders, Suicide History, severity,...
Context: Telephone-based disease management protocols have shown promise in improving outcomes a number of medical and psychiatric disorders, but this approach to continuing care has received little study alcohol-and drug-dependent individuals.Objective: To compare telephone-based with 2 more intensive face-to-face interventions.Design: A randomized 3-group clinical trial 2-year follow-up.Setting: Two outpatient substance abuse treatment programs, one community-based the other at Veterans...
Summary We present a linear rank preserving model (RPM) approach for analyzing mediation of randomized baseline intervention's effect on univariate follow‐up outcome. Unlike standard analyses, our does not assume that the mediating factor is also randomly assigned to individuals in addition intervention (i.e., sequential ignorability), but make several structural interaction assumptions currently are untestable. The G‐estimation procedure proposed RPM represents an extension work direct...
Alcohol is the second most common cause of cirrhosis necessitating liver transplantation in United States, yet rates posttransplant drinking approach 50% and no controlled clinical trials alcoholism treatment exist this population. Eligible patients were randomly assigned to receive Motivational Enhancement Therapy (MET), or referral local sources ("treatment as usual" [TAU]). Addictive behavior, mood states, general health compared. Candor concerning alcohol use was encouraged by keeping...
Alcohol use disorder is one of the leading causes disability worldwide. While effective pharmacological treatments exist, they are efficacious only in certain individuals, contributing to their limited use. Secondary analysis clinical trial data suggests that a functional polymorphism (rs1799971, Asn40Asp) µ-opioid receptor gene (OPRM1) associated with risk relapse heavy drinking following treatment opioid antagonist naltrexone.To prospectively examine whether rs1799971 predictive naltrexone...
Abstract Examined the chronological and statistical relations among onsets of psychopathology, alcohol cannabis use, substance-related problem problems from late childhood through early adolescence in boys fathers with substance use disorder (SUD; high average risk: n = 177) without SUD (low 203) using survival analysis. Proportional hazard models indicated that antisocial disorders were predicted by risk group mediated observed relation between problems. Negative affect but did not predict...
Repeated measurements and mixed-effects models were used to analyze the effects of an intensive long-term street-level police intervention on syringe exchange program use. Utilization data for 9 months before after beginning analyzed. Use fell across all categories time periods studied, with significant declines in use among total participants, male Black participants. Declines participants much more pronounced than decreases White female