A5101699564- Phytochemistry and Biological Activities
- Plant chemical constituents analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Sesquiterpenes and Asteraceae Studies
- NF-κB Signaling Pathways
- Phytochemical compounds biological activities
- Medicinal Plant Pharmacodynamics Research
- Traditional and Medicinal Uses of Annonaceae
- Neurological Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Synthesis of Organic Compounds
- Essential Oils and Antimicrobial Activity
- Natural Compound Pharmacology Studies
- Bioactive Compounds and Antitumor Agents
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- ATP Synthase and ATPases Research
- Plant Parasitism and Resistance
- Sphingolipid Metabolism and Signaling
- Ziziphus Jujuba Studies and Applications
- Traditional Chinese Medicine Analysis
- Cytokine Signaling Pathways and Interactions
Peking University
2016-2025
Peking University First Hospital
2010-2020
Korea Institute of Science and Technology
2010
Two new rare 8-methylbenzo[h]coumarins, muralatins A and B (1, 2), nine C-8-substituted coumarins, C–K (3–11), 22 known analogues (12–33) were isolated from the leaves of Murraya alata. The absolute configurations compounds 5, 11, 23, 24, 27, 30, 33 assigned via comparison their specific rotations, by Mosher's method, single-crystal X-ray diffraction electronic circular dichroism (ECD) data in situ formed transition metal complexes. putative biosynthesis pathway to 1 2 is proposed, chemical...
Microglial-mediated neuroinflammation has been established as playing a vital role in pathogenesis of neurodegenerative disorders. Thus, rational regulation microglia functions to inhibit inflammation injury may be logical and promising approach disease therapy. The purposes the present study were explore neuroprotective effects potential molecular mechanism Schizandrin A (Sch A), lignin compound isolated from Schisandra chinesnesis. Our observations showed that Sch could significantly...
The hypothalamus plays a fundamental role in controlling lipid metabolism through neuroendocrine signals.However, there are currently no available drug targets the that can effectively improve human metabolism.In this study, we found antimalarial artemether (ART) significantly improved by specifically inhibiting microglial activation of high-fat diet-induced mice.Mechanically, ART protects thyrotropin-releasing hormone (TRH) neurons surrounding cells from inflammatory damage and promotes...
The traditional Chinese medicine Cistanche deserticola has been reported to be valid for cardiovascular and cerebrovascular diseases. However, its active components the protection of ischemic stroke are not clear. We aimed explore C. against as well potential mechanisms.We investigated brain protective effects extracts from deserticola, total glycosides (TGs), polysaccharides (PSs), oligosaccharides (OSs) in a rat model middle cerebral artery occlusion-reperfusion (MCAO/R). 2, 3,...
Abstract Fifteen novel carbazole alkaloids, euchrestifolines A–O ( 1 – 15 ), were obtained from Murraya euchrestifolia . Their structures elucidated by spectroscopic analysis, Mosher’s ester, calculated ECD, and transition metal complex ECD methods. Notably, A–C 3 ) are the first naturally occurring pyrrolidone carbazoles to be identified, while D–F 4 6 represent rare alkaloids containing a phenylpropanyl moiety; euchrestifoline G 7 features unique benzopyranocarbazole skeleton. More...
Exotines A and B (1 2), two heterodimers of isopentenyl-substituted indole coumarin derivatives linked through a new fused heptacyclic ring system, were isolated from the roots Murraya exotica. Their structures established by comprehensive NMR MS spectroscopic data analysis, absolute configurations determined single-crystal X-ray crystallographic analysis ECD calculations. Compounds 1 2 showed inhibition nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells with IC50...
Abstract Nine guaiane‐type sesquiterpenes and one eudesmane‐type – namely argyinolides A–J ( 1 10 ) as well nine known analogues were isolated from the leaves of Artemisia argyi Levl. et Vant. Their structures determined by interpretation spectroscopic data (MS, 1D 2D NMR). A combination X‐ray crystal diffraction, specific optical rotations, CD spectroscopy, ECD calculation, Mosher ester methods was employed to resolve absolute configurations compounds. Biological investigations into their...
Three new prenylated phenylpropenols, exotiacetals A–C (1–3), 10 coumarin derivatives, exotimarins A–I (4–13), and 35 known analogues (14–48) were isolated from the roots of Murraya exotica. The absolute configurations compounds assigned via comparison their specific rotations, single-crystal X-ray diffraction data, Mosher's method, ECD exciton coupling experimental calculated data in situ formed transition metal complexes. Compounds 1–3, which possess an unprecedented...
Twelve new dimeric sesquiterpenoids (1-12) were isolated from the dried whole plants of Artemisia rupestris. Their structures determined using MS and NMR data, absolute configurations elucidated on basis experimental calculated ECD spectra. Compounds 1-9 are presumably formed via biocatalyzed [2+2] or [4+2] cycloaddition reactions. Stereoselectivity Diels-Alder reaction dictated formation endo-products. The exhibited moderate inhibition NO production stimulated by lipopolysaccharide in BV-2...
Diabetic encephalopathy (DE) is a serious complication caused by long-term cognitive impairment in diabetic patients. At present, there no effective treatment for DE. Icariin (ICA) bioactive ingredient isolated from Epimedium . Previous research indicated that ICA was neuroprotective against A β -induced PC12 cell insult; however, the effect of on an advanced glycosylation end product- (AGE-) induced neural injury model has not been studied. In this study, we investigated effects AGE-induced...
Bioactive natural products are invaluable sources for drug discovery. Unraveling their molecular targets uncovers the mechanisms of action and provides novel development. However, current approaches target identification fall short in terms efficiency, due to extensive list candidates limited functional clues. Here we pioneer a strategy that integrates thermal proteome profiling proximity co-aggregation (TPP-TPCA) high-efficient identification. By linking downstream perturbed protein...
MC13 is a novel coumarin compound found in Murraya, an economic crop whose leaves are widely used as condiment (curry) cuisine. The aims of the present study were to investigate neuroprotective effects on microglia-mediated inflammatory injury model well potential molecular mechanism. Cell viability and apoptosis assay demonstrated that was not toxic neurons significantly protected from upon lipopolysaccharide (LPS) stimulation. Results showed markedly inhibited LPS-induced production...
Two new structurally unique trimeric carbazole alkaloids, murratrines A and B (1, 2), 11 dimers, murradines A–K (3–13), four known analogues (14–17) were isolated from the leaves stems of Murraya tetramera. The structures relative configurations 1–13 elucidated on basis comprehensive 1D 2D NMR spectroscopy, high-resolution mass spectrometry, electronic circular dichroism (ECD) data analysis. Murratrines 2) both contain an unprecedented skeleton, D (3, 6) are first natural...