A5084967433- Physics of Superconductivity and Magnetism
- Quantum and electron transport phenomena
- Neurological Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Medicinal Plant Pharmacodynamics Research
- Advanced Condensed Matter Physics
- stochastic dynamics and bifurcation
- Flavonoids in Medical Research
- Alzheimer's disease research and treatments
- Traditional Chinese Medicine Analysis
- Quantum Information and Cryptography
- Magnetic properties of thin films
- Phagocytosis and Immune Regulation
- Advanced Chemical Physics Studies
- Genetic and Kidney Cyst Diseases
- Barrier Structure and Function Studies
- Genetics, Aging, and Longevity in Model Organisms
- Immune cells in cancer
- Diabetes Treatment and Management
- Cell Adhesion Molecules Research
- Pharmacology and Obesity Treatment
- High-pressure geophysics and materials
- Lipoproteins and Cardiovascular Health
- Electronic and Structural Properties of Oxides
- Phytochemistry and biological activity of medicinal plants
Institute of Electrical Engineering
2024
Chinese Academy of Sciences
2006-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Guangzhou University of Chinese Medicine
2021-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2021-2022
Peking University First Hospital
2018-2021
Peking University
2018-2021
Xiyuan Hospital
2021
Guangzhou Institutes of Biomedicine and Health
2018-2019
Institute of Physics
2003-2019
The class III PI3-kinase (PIK3C3) is an enzyme responsible for the generation of phosphatidylinositol 3-phosphate (PI3P), a critical component vesicular membrane. Here, we report that PIK3C3 deficiency in zebrafish results intestinal injury and inflammation. In pik3c3 mutants, gut tube forms but fails to be maintained. Gene expression analysis reveals barrier-function-related inflammatory bowel disease (IBD) susceptibility genes (e-cadherin, hnf4a, ttc7a) are suppressed, while response...
Hematopoietic stem cells (HSCs)/progenitor (HPCs) are generated from hemogenic endothelial (HECs) during the endothelial-to-hematopoietic transition (EHT); however, underlying mechanism remains poorly understood. Here, using an array of approaches, including CRSPR/Cas9 gene knockouts, RNA-Seq, ChIP-Seq, ATAC-Seq etc., we report that vitamin C (Vc) is essential in HPC generation human pluripotent cell (hPSC) differentiation defined culture conditions. Mechanistically, found absence Vc fail to...
Diabetic encephalopathy (DE) is a serious complication caused by long-term cognitive impairment in diabetic patients. At present, there no effective treatment for DE. Icariin (ICA) bioactive ingredient isolated from Epimedium . Previous research indicated that ICA was neuroprotective against A β -induced PC12 cell insult; however, the effect of on an advanced glycosylation end product- (AGE-) induced neural injury model has not been studied. In this study, we investigated effects AGE-induced...
Recently, it has been found that the level of urinary D-ribose in type 2 diabetes is notably higher than age-matched normal control, and more reactive glycation D-glucose induces oxidative stress. Kaempferol one main bioactive components Astragalus membranaceus , with numerous physiological actives, such as antioxidant. The present study investigated protective effects kaempferol on D-ribose-treated mesangial cells. CCK-8 LDH assay were used to test cell viability toxicity....
Centriolar satellites are non-membrane cytoplasmic granules that deliver proteins to centrosome during biogenesis and ciliogenesis. highly dynamic cell cycle or ciliogenesis how they regulated remains largely unknown. We report here sorting nexin 17 (SNX17) regulates the homeostasis of a subset centriolar satellite including PCM1, CEP131, OFD1 serum-starvation-induced Mechanistically, SNX17 recruits deubiquitinating enzyme USP9X antagonize mindbomb 1 (MIB1)-induced ubiquitination degradation...
The properties of phase escape in a dc superconducting quantum interference device (SQUID) at 25 mK, which is well below quantum-to-classical crossover temperature ${T}_{cr}$, the presence strong resonant ac driving have been investigated. SQUID contains two $\text{Nb}/{\text{Al-AlO}}_{x}/\text{Nb}$ tunnel junctions with Josephson inductance much larger than loop so it can be viewed as single junction having adjustable critical current. We find that increasing microwave power $W$ and certain...
Hybrid superconducting devices based on high-mobility two-dimensional electron gases with strong spin-orbit coupling are considered to offer a flexible and scalable platform for topological quantum computation. Here, we report the realization electrical characterization of hybrid high-quality InSb nanosheets niobium (Nb) electrodes. In these devices, observe gate-tunable proximity-induced supercurrent multiple Andreev reflections, indicating transparent Nb-InSb nanosheet interface. The high...
Type 2 Diabetes mellitus (T2DM) is closely correlated with cognitive impairment and neurodegenerative disease. Bushen Huoxue (BSHX) a compound Chinese medicine used clinically to treat diabetes-induced impairment. However, its underlying mechanisms remain unclear. In the present study, KKAy mice, genetic model of type diabetes obesity insulin resistant hyperglycemia, received daily administration BSHX for 12 weeks. Blood glucose was measured every four After weeks, treatment significantly...
We report the observation of quantum stochastic synchronization (QSS) in a dissipative system---a moderately damped current-biased Josephson junction. show that when junction is biased subcritically by combination constant current and small sinusoidal modulation signal, forced phase between otherwise random, incoherent tunneling signal may arise as consequence interplay fluctuation weak periodic drive. It found optimal occurs at frequency ${f}_{\text{QSS}}$ comparable to rate. also find...
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome featuring ectopic lipid accumulation in hepatocytes. NAFLD has been a severe threat to humans with global prevalence over 25% yet no approved drugs for treatment date. Previous studies showed that procyanidin B2 (PCB2), an active ingredient from herbal cinnamon, excellent hepatoprotective effect; however, mechanism remains inconclusive. The present study aimed investigate protective effect and...
To effectively implement quantum algorithms on noisy intermediate-scale (NISQ) processors is a central task in modern technology. NISQ feature tens to few hundreds of qubits with limited coherence times and gate operations errors, so naturally require employing circuits short lengths via compilation. Here, we develop reinforcement learning (RL)-based compiler for superconducting processor demonstrate its capability discovering novel hardware-amenable lengths. We show that the three-qubit...
CRISPR/Cpf1 system is a novel genomic editing tool. Because of its more sophisticated components, and lower off-target rate, it has the potential to become better gene-editing Previous reports showed that could work effectively in multiple species. But our data show AsCpf1 activity big difference different vertebrates. Using vitro experiments, we finally learned between species due temperature.
The SQUID microscope is the most suitable instrument for imaging magnetic fields above sample surfaces if one mainly interested in field sensitivity. In this paper, both moment sensitivity and spatial resolution of are analysed with a simple point model. result shows that ratio sensor size to sensor–sample distance effectively influences resolution. comparison some experimental results images room temperature samples from our high-Tc an unshielded environment, brief discussion further...
Diabetic cognitive impairment is one of the common complications type 2 diabetes, which can cause neurological and microvascular damage in brain. Bushen Huoxue prescription (BSHX), a compound Chinese medicine, has been used clinically to treat diabetes-induced impairment. However, its underlying mechanisms remain unclear. In this study, KK-Ay diabetic model mouse was administered BSHX daily for 12 weeks. Bodyweight, random blood glucose (RBG), fasting (FBG) were measured every 4...
Calamine and its related medicines came into China as articles of tribute from other countries in ancient times. It was not recorded the books Chinese materia medica before Song Dynasty but widely used ophthalmology, dermatology traumatology was, specifically Ming Qing Dynasty. This paper systematically examines evolution calamine herb archives traditional medicine terms ophthalmic eternal treatment prescriptions. found that a total 320 formulas or prescriptions involved calamine, mainly...
Femtosecond pump-probe spectroscopy has been used to study ultrafast relaxation dynamics in low-temperature-grown AlGaAs/GaAs multiple quantum wells (MQW's). It was found that the carrier lifetime of as-grown MQW's much longer than those had subjected 30 s rapid thermal annealing. The lifetimes samples annealed three different temperatures (600, 700, and $800\ifmmode^\circ\else\textdegree\fi{}\mathrm{C})$ were measured $700\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$ be shorter other two....
We aimed to assess the efficacy of Jiang Tang San Huang (JTSH) tablet for treatment patients with type 2 diabetes mellitus (T2DM).