A5100445602- Acute Myeloid Leukemia Research
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Neurogenesis and neuroplasticity mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Platelet Disorders and Treatments
- Neuroscience of respiration and sleep
- Vestibular and auditory disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine regulation and behavior
- Amino Acid Enzymes and Metabolism
- Hematopoietic Stem Cell Transplantation
- RNA Interference and Gene Delivery
- Circadian rhythm and melatonin
- Protein Degradation and Inhibitors
- Nitric Oxide and Endothelin Effects
- S100 Proteins and Annexins
Nantong University
2014-2025
First Affiliated Hospital Zhejiang University
2016-2025
Yancheng Third People's Hospital
2024-2025
Beijing University of Chinese Medicine
2025
Zhejiang University
2015-2024
Affiliated Hospital of Nantong University
2024
Shandong University
2023
La Trobe University
2018-2023
Kunming Children's Hospital
2022-2023
Hangzhou Cancer Hospital
2023
Hematopoietic stem cell (HSC) aging is accompanied by hematopoietic reconstitution dysfunction, including loss of regenerative and engraftment ability, myeloid differentiation bias, elevated risks malignancies. Gut microbiota, a key regulator host health immunity, has recently been reported to affect hematopoiesis. However, there currently limited empirical evidence explaining the direct impact gut microbiome on In this study, we performed fecal microbiota transplantation (FMT) from young...
The data presented here are the first to describe distribution of estrogen receptor-β(ERβ)-like immunoreactivity in brain tissue. We employed an affinity purified rabbit antisemm made against a portion C-terminal ERβ protein. majority ERβ-like immunoreactive (ERβ-ir) neurons were found following regions: lateral septum, bed nucleus stria terminalis, paraventricular nucleus, supraoptic medial amygdala, dentate gyms and CA1 CA2 fields hippocampus. A few ERβ-ir noted anterior hypothalamus,...
Abstract NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in proliferation and give rise to myelinating oligodendrocytes during early brain development. In contrast other glial cell types, the most intriguing aspect of glia is their ability directly sense synaptic inputs from neurons. However, whether this interaction bidirectional or unidirectional, its physiological relevance has not yet been clarified. Here, we report that form complexes with...
Traumatic brain injury (TBI) is one of the leading causes neurological disability in young adults. Edaravone, a novel synthetic small-molecule free-radical scavenger, has been shown to have neuroprotective effect both animal models cerebral ischemia and stroke patients; however, underlying mechanism poorly understood. In this report, we investigated potential mechanisms edaravone treatment rat model TBI. TBI was induced right cortex male adult rats using Feeney's weight-drop method....
Selective elimination of unwanted synapses is vital for the precise formation neuronal circuits during development, but underlying mechanisms remain unclear. Using inositol 1,4,5-trisphosphate receptor type 2 knockout (Itpr2−/−) mice to specifically disturb somatic Ca2+ signaling in astrocytes, we showed that developmental ventral posteromedial nucleus relay synapse was impaired. Interestingly, intracerebroventricular injection ATP, not adenosine, rescued deficit Itpr2−/− mice. Further...
When infecting host cells, influenza virus must move on microfilaments (MFs) at the cell periphery and then along microtubules (MTs) through cytosol to reach perinuclear region for genome release. But how viruses switch from actin roadway microtubule highway remains obscure. To settle this issue, we systematically dissected role of related motor proteins in transport between cytoskeletal filaments situ real-time using quantum dot (QD)-based single-virus tracking (SVT) multicolor imaging. We...
Highlights•Kdm5a promotes NK cell activation by regulating interferon-γ production•Kdm5a inhibits SOCS1 expression and STAT4 activation•Kdm5a is recruited to the promoter p50 maintain a repressive chromatin configuration•Kdm5a required for clearance of LmSummaryThe H3K4me3 demethylase Kdm5a regulates gene transcription implicated in carcinogenesis. However, role innate immune response remains poorly understood. Here, we demonstrate that deficiency impairs natural killer (NK) cells, with...
Significance Neuronal cells maintain a small number of synaptic vesicles (SVs) that are “primed,” i.e., ready to release upon receiving the triggering signal allow for tightly regulated and rapid neurotransmitters. The proteins involved in this process known, but how they assemble operate together is poorly understood. Here we report visualization protein organization under primed SVs cultured neurons native conditions. Using cryoelectron tomography analysis, find there symmetric arrangement...
Abstract Background At present, the hereditary hearing loss homepage, ( https://hereditaryhearingloss.org/ ), includes 258 deafness genes and more than 500 that have been reported to cause deafness. With few exceptions, region-specific distributions are unclear for many of identifie d variants genes. Methods Here, we used a custom capture panel perform targeted sequencing 518 in cohort 879 deaf Chinese probands who lived Yunnan. Mutation sites parents were performed by high-throughput...
There is currently a paucity of reliable techniques for predicting the response breast tumors to neoadjuvant chemotherapy. The standard approach monitor gross changes in tumor size as measured by physical exam and/or conventional imaging, but these methods generally do not show whether responding until patient has received many treatment cycles. One promising address this clinical need integrate quantitative vivo imaging data into biomathematical models growth order predict eventual based on...