A5106233314- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Virus-based gene therapy research
- Geological and Geochemical Analysis
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- High-pressure geophysics and materials
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- earthquake and tectonic studies
- Genomics, phytochemicals, and oxidative stress
- Marine Sponges and Natural Products
- Advanced Photocatalysis Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Autophagy in Disease and Therapy
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- Protein Degradation and Inhibitors
- Blood Coagulation and Thrombosis Mechanisms
- Ubiquitin and proteasome pathways
Changchun Institute of Applied Chemistry
2023-2025
Chinese Academy of Sciences
1995-2025
University of Science and Technology of China
2023-2025
State Key Laboratory of Rare Earth Resources Utilization
2025
University of Wisconsin–Madison
2025
Sichuan University
2002-2024
State Key Laboratory of Biotherapy
2013-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Shenzhen Institutes of Advanced Technology
2023
China Medical University
2023
Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally,...
Ultrasound (US)-mediated piezocatalytic tumor therapy has attracted much attention due to its notable tissue-penetration capabilities, noninvasiveness, and low oxygen dependency. Nevertheless, the efficiency of is limited an inadequate piezoelectric response, separation electron–hole (e––h+) pairs, complex microenvironment (TME). Herein, ultrathin two-dimensional (2D) sulfur-vacancy-engineered (Sv-engineered) Cu@SnS2–x nanosheet (NS) with enhanced effect was constructed via heterovalent...
Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites,...
Tumor immunotherapy has been widely used clinically, but it is still hindered by weak antitumor immunity and immunosuppressive tumor microenvironment (TME). Here, a kind of simple disodium hydrogen phosphate nanoparticle (Na2HPO4 NP) prepared to "accelerate" "increasing throttle" "relaxing brake" simultaneously. The obtained Na2HPO4 NPs release large amount Na+ HPO42‐ ions within cells, thereby activating the caspase 1/GSDMD‐mediated pyroptosis pathway achieve immune activation. Meanwhile,...
Abstract To improve the efficiency and application prospects of metal peroxides in tumor therapy, synthesis bimetallic via simple yet effective approaches will be highly significant. In this work, hyaluronic acid modified zinc‐copper (ZCPO@HA) nanoparticles are synthesized through a one‐step symbiotic method by co‐hydrolysis zinc acetate copper weakly alkaline solution, followed modification with sodium hyaluronate. Upon decomposition microenvironment, ZCPO@HA can generate considerable...
Metabolic reprogramming, as one of the characteristics cancer, is associated with tumorigenesis, growth, or migration, and modulation metabolic pathways has emerged a novel approach for cancer therapy. However, conventional metabolism-mediated apoptosis process in tumor cells exhibits limited immunogenicity inadequate activation antitumor immunity. Herein, phospholipid-coated sodium citrate nanoparticles (PSCT NPs) are successfully prepared, which dissolve then release significant amounts...
Triple-negative breast cancer (TNBC) has been clearly recognized as a heterogeneous tumor with the worst prognosis among subtypes of (BC). The advent and application current small-molecule drugs for treating TNBC, well other novel inhibitors, others, have made treatment options TNBC more selective. However, there are still problems, such poor patient tolerance, large administration doses, high dosing frequency, toxic side effects, necessitating development efficient less strategies. High...
Highly proliferative and reactive oxygen species (ROS) overexpression make pancreatic cancer upregulate cysteine (Cys) uptake to maintain redox homeostasis, which indicates that Cys may be a potential target for the treatment of cancer. Herein, polyvinylpyrrolidone (PVP) modified CuO nanoparticles (PVPCuO NPs) are proposed first inducing imbalance initiated by depletion. The PVPCuO NPs not only deplete produce H2O2 but also exhibit peroxidase (POD)-like activity, efficiently converting into...
Abstract Mesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent biocompatibility, easy‐to‐modify surface, adjustable particle size, and remarkable immuno‐enhancing activity. However, the application of MSNs is still greatly limited by some severe challenges including unclear complicated relationships structure immune effect. Herein, three commonly used with different skeletons MSN tetrasulfide bonds (TMSN),...
Abstract Acute myeloid leukemia (AML) is a heterogeneous malignant blood cancer that occurs mainly in the elderly. Its treatment outcome greatly influenced by leukemia-driving mutations. Oncogenic NRAS mutations are associated with both AML progression and multi-drug resistance failure AML. We have previously developed NRAS; ASXL1-driven secondary (NA-AML) mouse model, which characterized suppressive immune microenvironment resulting reduced killing activities of T cells. Targeting...
Tumor immunotherapy has been widely used clinically, but it is still hindered by weak antitumor immunity and immunosuppressive tumor microenvironment (TME). Here, a kind of simple disodium hydrogen phosphate nanoparticle (Na2HPO4 NP) prepared to "accelerate" "increasing throttle" "relaxing brake" simultaneously. The obtained Na2HPO4 NPs release large amount Na+ HPO42‐ ions within cells, thereby activating the caspase 1/GSDMD‐mediated pyroptosis pathway achieve immune activation. Meanwhile,...
Pyroptosis hold great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference (IIT), are developed induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear. It was reported that MoO42− ions could stimulate immune responses, but their pyroptosis‐inducing mechanisms were not fully understood. Herein, we synthesized uniform and dispersed silver molybdate (Ag2MoO4) nanoparticles (AMO) via a...
Pyroptosis hold great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference (IIT), are developed induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear. It was reported that MoO42− ions could stimulate immune responses, but their pyroptosis‐inducing mechanisms were not fully understood. Herein, we synthesized uniform and dispersed silver molybdate (Ag2MoO4) nanoparticles (AMO) via a...
Abstract Immunotherapeutic efficacy is often limited by poor immunogenicity, immunosuppressive tumor microenvironment (TME), and cytoprotective mechanisms, leading to low immune activation. To this end, here, L‐amino acid oxidase (LAAO) loaded gallium‐magnesium layered double hydroxide (MG‐LAAO) prepared for significantly enhanced immunotherapy through multi‐network synergistic regulation. First, MG‐LAAO induces cell pyroptosis initiating caspase‐1/GSDMD caspase‐3/GSDME pathways, further...
Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally,...
Abstract Single‐atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)‐mediated cancer therapy. However, the high energy barriers of reaction intermediates on single‐atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi‐enzyme mimetic MoCu dual‐atom nanozyme (MoCu DAzyme) various catalytic...