A5101950494- Skin and Cellular Biology Research
- Coral and Marine Ecosystems Studies
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Genetic and phenotypic traits in livestock
- Wnt/β-catenin signaling in development and cancer
- Virus-based gene therapy research
- Microbial Community Ecology and Physiology
- Ruminant Nutrition and Digestive Physiology
- RNA and protein synthesis mechanisms
- RNA regulation and disease
- Viral Infections and Immunology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Hair Growth and Disorders
- Marine and fisheries research
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Cancer and Skin Lesions
- Epigenetics and DNA Methylation
- Evaluation Methods in Various Fields
- Genetic and rare skin diseases.
- Plant Molecular Biology Research
- Animal Nutrition and Physiology
- Medicinal Plant Pharmacodynamics Research
- Plant Virus Research Studies
Nanjing Medical University
2021-2025
Changzhi Medical College
2025
Huazhong Agricultural University
2013-2024
James Cook University
2018-2024
Australian Institute of Tropical Health and Medicine
2020-2024
Shanxi Medical University
2024
The University of Queensland
2024
University of Malaya
2024
Chongqing University of Education
2024
Guangdong Ocean University
2023-2024
Genomes of 150 coral colonies reveal evolutionary processes related to past climatic change on the Great Barrier Reef.
Dimethylsulfoniopropionate (DMSP) is an important molecule in the marine sulfur cycle, produced large amounts by corals and their dinoflagellate endosymbionts, Symbiodiniaceae. Although are known to harbour bacteria that can catabolise DMSP, recent discovery of capable producing DMSP coastal deep-sea environments raises possibility a bacterial contribution output corals. Here, 157 associated with four common coral species were isolated screened for ability produce targeting dsyB , key gene...
Colorimetric recognition and sensing of sulfide with high selectivity by virtue glutathione-modified gold nanoparticle (GSH-AuNP) is presented. The assay developed based on a specific anion-for-molecule ligand exchange reaction, through which replaces glutathione self-assembled the AuNP. unique feature GSH-AuNP probe makes it novel colorimetric sensor for sulfide.
Herein we report the "OR" and "AND" colorimetric logic gates for small molecules using split/integrated aptamers unmodified gold nanoparticles, which generate visually observed outputs according to Boolean operations.
Abstract Neurofibromatosis type 1 ( NF1 ) is an autosomal dominant hereditary disease that primarily characterized by multiple café au-lait spots (CALs) and skin neurofibromas, which are attributed to defects in the tumor suppressor . Because of age-dependent presentation NF1, it often difficult make early clinical diagnosis. Moreover, identifying genetic alterations patients represents a complex challenge. Currently, there no effective detective methods comprehensive mutation data available...
Type 2 diabetes mellitus (T2DM) is characterized by the inability of insulin-producing β-cells to overcome insulin resistance. We previously identified an imprinted region on chromosome 14, DLK1-MEG3 locus, as being downregulated in islets from humans with T2DM. In this study, using targeted epigenetic modifiers, we prove that increased methylation at promoter Meg3 mouse βTC6 results decreased transcription maternal transcripts associated locus. As a result, sensitivity cytokine-mediated...
A colorimetric probe based on 2-mercaptosuccinic acid-functionalized gold nanoparticles has been developed to exhibit selectivity towards Ca2+, Sr2+, and Ba2+ ions over other metallic cations under specified conditions finds its practical application in detecting Ca2+ levels water.
Abstract Olmsted syndrome (OS) is a rare keratinization disorder, typically characterized by two primary diagnostic hallmarks—mutilating palmoplanter and periorificial keratoderma. However, there’s growing body of literature reporting on the phenotypic diversity OS, including absence aforementioned hallmarks presence some unusual clinical features. Here we presented an atypical familial case OS that could be confused with Huriez due to scleodactyly-like appearance tapered fingers in proband....
Geographic tongue (GT) is a benign inflammatory disorder of unknown etiology. Epidemiology and histopathology in previous studies found that generalized pustular psoriasis (GPP) factor associated with GT, but the molecular mechanism remains obscure. To investigate without GPP, three cohorts were recruited to conduct genotyping IL36RN, which causative gene GPP. In family spanning generations diagnosed only GT ("GT alone"), was caused by c.115+6T>C/p.Arg10ArgfsX1 mutation IL36RN gene. An...
Abstract Many genes encoding CCT domain‐containing proteins regulate flowering time. In rice ( Oryza sativa ), 41 such have been identified, but only a few shown to heading date. Here, test whether and how additional family date in rice, we classified these into five groups based on their diurnal expression patterns. The patterns of the same subfamily or close phylogenetic clades tended be similar. We generated knockout mutants entire gene via CRISPR/Cas9. dates 4 14 previously were altered,...
Abstract Climate change threatens the survival of coral reefs on a global scale, primarily through mass bleaching and mortality as result marine heatwaves. While these short-term effects are clear, predicting fate over coming century is major challenge. One way to understand longer-term effect rapid climate examine response populations past shifts. Coastal shallow-water ecosystems such have been reshaped many times by sea-level changes during Pleistocene, yet few studies directly linked this...
C2H2-type zinc finger proteins are classic and extensively studied members of the family. participate in plant growth, development stress responses. In this study, 99 protein genes were identified classified into four groups, many functionally related cis-elements identified. Differential C2H2-ZFP gene expression specific responses analyzed under drought, cold, salt, pathogen stresses based on RNA-Seq data. Thirty-two C2H2 response to multiple stresses. Seven, 3, 5, 8 specifically expressed...
This study was conducted to investigate the effects of chitosan oligosaccharide (COS) supplementation on intestinal development and functions, inflammatory response, antioxidant capacity related signaling pathways in broilers aged d 1 14. A total 240 one-day old male Arbor Acres (40.47 ± 0.30 g) were randomly allotted 4 groups, each group consisted 6 replicate pens with 10 per replicate. Broilers fed a basal diet COS at 0 (CON group), 200 (COS200 400 (COS400 800 mg/kg (COS800 group) for 14...
Cold airflow experiments were conducted within a small-scale furnace of down-fired pulverized-coal 300 MWe utility boiler. With focus on the large combustion difference between zones near front and rear walls in boilers, we investigate aerodynamic field at different staged-air declination angles 0°, 15°, 30°, 45°, 55°. For deflected flow appeared lower furnace, with downward velocities wall decaying more rapidly than wall. In addition to reach into turbulence intensity longitudinal-velocity...
Neurogenin 1 (ngn1), with the functions of controlling differentiation neurons, determining specific neuronal subtype, and inhibiting glial differentiation, is quantitatively detected for first time. By using specifically modified silver nanoparticles (AgNP) as signaling element, a label-free, rapid sensitive colorimetric immunoassay synthetic peptide fragment ngn1 (amino acid sequence: AQDDEQERRRRRGRTR) reported. The detection procedure based on an anti-aggregation mechanism, by which...
The evolutionary outcomes of high elevation adaptation have been extensively described. However, whether widely distributed endemic animals adopt uniform mechanisms during to different elevational environments remains unknown, especially with respect extreme environments. To explore this, we analysed the phenotypic and genomic data seven populations plateau zokor (Myospalax baileyi) along elevations ranging from 2,700 4,300 m. Based on whole-genome sequencing demographic reconstruction...
The future survival of coral reefs in the Anthropocene depends on capacity corals to adapt as oceans warm and extreme weather events become more frequent. Targeted interventions designed assist evolutionary processes require a comprehensive understanding distribution structure standing variation, however, efforts map genomic variation have so far focussed almost exclusively SNPs, overlooking structural variants that been shown drive adaptive other taxa. Here, we show reef-building coral,...
Olmsted syndrome (OS) is a rare disorder characterized by mutilating palmoplantar keratoderma and periorificial keratotic plaques, but which shows considerable clinical heterogeneity. Recently, transient receptor potential vanilloid 3 ( TRPV3 ) mutations associated with autosomal dominant or recessive OS have been reported. Here we describe classically case definitive diagnosis of based on features genetic assay. Genetic analysis revealed heterozygous variants in the gene using whole-exome...