A5101418356- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Renal and related cancers
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Periodontal Regeneration and Treatments
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Shoulder Injury and Treatment
- Advanced Breast Cancer Therapies
- Corneal Surgery and Treatments
- Sarcoma Diagnosis and Treatment
- Surgical Sutures and Adhesives
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Bone fractures and treatments
- Cancer Treatment and Pharmacology
- Wound Healing and Treatments
- Pediatric Urology and Nephrology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Diabetic Foot Ulcer Assessment and Management
Shanghai Jiao Tong University
2019-2025
Renji Hospital
2008-2025
Nanchong Central Hospital
2025
Tsinghua University
2024
Changchun University of Chinese Medicine
2024
Children's Hospital of Zhejiang University
2018-2024
Southwest Hospital
2019-2023
Inner Mongolia People's Hospital
2023
Nantong University
2021-2022
Shanxi Medical University
2006-2022
NLRP1 (NLR family, pyrin domain containing 1), the first NLR protein, described to form an inflammasome, plays critical roles in innate immunity and inflammation. However, has not been reported be linked LUAD (lung adenocarcinoma) risk, prognosis, immunotherapy or any other treatments. This research aimed explore prognostic value mechanism of LUAD. We performed bioinformatics analysis on data downloaded from TCGA (The Cancer Genome Atlas) GEO (Gene Expression Omnibus), jointly analyzed with...
Autologous platelet-rich plasma (au-PRP) has been widely used for the management of refractory chronic wounds. However, patients with diabetic lower extremity ulcers (DLEUs) usually have complicated clinical conditions, and utility au-PRP is limited. In this study, feasibility, effectiveness, safety allogeneic (al-PRP) were investigated compared in treatment DLEUs. A total 75 in-patients type 2 diabetes assigned to al-PRP group ( n = 20), 25), conventional wound therapeutic (CWT) 30) matched...
To develop and validate a machine learning-based CT radiomics method for preoperatively predicting the stages (stage I non-stage I) of Wilms tumor (WT) in pediatric patients. A total 118 patients with WT, who underwent contrast-enhanced computed tomography (CT) scans our center between 2014 2021, were studied retrospectively divided into two groups: stage disease. Patients randomly training cohorts (n = 94) test 24). 1,781 radiomic features from seven feature classes extracted preoperative...
Background There is no effective drug treatment for the organ failure (OF) caused by severe acute pancreatitis (SAP). Objective We aimed to evaluate efficacy of cyclooxygenase-2 inhibitors (COX-2-Is) on SAP and its safety. Design In this multicentre, double-blind, randomised, placebo-controlled, investigator-initiated trial, 348 patients with aged 18–75 years, <1 week from onset illness admission, Acute Physiology Chronic Health Evaluation II Score ≥7 or modified Marshall ≥2, were...
In the phase 3 FLAURA trial, osimertinib was compared with first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as a first-line treatment for EGFR-mutant non-small cell lung cancer (NSCLC). Osimertinib showed longer progression-free survival (PFS), overall (OS), and similar safety profile. However, more studies demonstrating effectiveness of strategy are needed in real-world populations.We enrolled 1,556 patients EGFR-mutated stage IIIc-IV NSCLC from...
This study investigated the effect of mesenchymal stem cell implantation on flexor tendon healing using a rabbit model repair. Specifically, we compared difference between autologous and allogeneic cells. The influence number outcome was also investigated.Repaired tendons rear paws rabbits were randomly assigned into four groups: control group, 1 million cells, 4 Rabbits sacrificed at 3 or 8 weeks after surgery.Implantation cells resulted in significant increase range motion with group three...
Abstract Background Experiencing a hyperglycaemic crisis is associated with short- and long-term increased risk of mortality. We aimed to develop an explainable machine learning model for predicting 3-year mortality providing individualized factor assessment patients after admission. Methods Based on five representative algorithms, we trained prediction models data from admitted two tertiary hospitals between 2016 2020. The were internally validated by tenfold cross-validation externally...
Head and neck cancer is 1 of the major global health issues but received limited attention, its incidence has rarely been systematically studied in China.The population-based registry urban Tianjin was used to examine changing pattern rates potential causes China.Between 1981 2002, age-standardized rate (ASIR) head decreased by 1.39% per year among males 2.20% females. Significant decreasing trends were found for age group 45 54 years women 55 64 both men women. Slight increasing 0 44...
Fibrin glue has been widely used in a variety of surgical procedures to promote haemostasis and tissue bonding. It can also be as cell carrier for stem cells on tendons. However, the data about effect fibrin flexor tendon healing is very limited. The present study examined role TISSEEL® rabbit model injury. rabbits were killed 3 or 8 weeks after operation. range-of-motion fingers biomechanical properties tendons measured compared between control group TISSEEL-treated group. findings have...
Abstract Background Three‐dimensional visualization preoperative evaluation ( 3D‐VPE) and enhanced recovery after surgery (ERAS) have been suggested to improve outcomes of cancer in patients, yet little is known regarding their clinical benefit patients with gallbladder (GBC). We hypothesized that the combination 3D‐VPE ERAS would outcome undergoing for GBC. Objective This study aimed determine if can overall survival GBC, establishing a novel patient management strategy Methods A total 227...
Purpose: TNBC is generally more aggressive than other BC subtypes and has limited therapeutic options. We aimed to construct comprehensive reliable nomograms predict the OS BCSS of patients offer clinicians guidance for improving prognosis patients. Patients methods: used SEER 19 Cancer Registry identify 21,419 eligible diagnosed from January 1, 2010 December 31, 2015, divided database randomly into a training cohort (n=10,709) validation (n=10,710). The log-rank test Cox analysis together...
Abstract Background Endocrine therapy is the preferred treatment for patients with hormone receptor ‐positive metastatic breast cancer (MBC). While visceral metastasis a negative prognostic factor, few studies have distinguished between prognoses of metastases at different sites. Patients and methods In total, 398 receiving fulvestrant 500 mg single center over 6‐year period were analyzed. Logistic regression models used to identify factors associated progression‐free survival (PFS)....
Background: Endoscopic ultrasonography (EUS) is widely used as a staging modality for gastric cancer. However, the results of studies on use EUS N in cancer vary. This study aimed at studying overall diagnostic accuracy Methods: Published were identified through searching MEDLINE, Web Science, EMBASE, SpringerLink and ScienceDirect databases. A bivariate random effect model was to estimate sensitivity, specificity, positive likelihood ratio (PLR), negative (NLR), odds (DOR). hierarchical...
Background: Inducible co-stimulator (ICOS) is a cell-enhanced co-stimulatory receptor that has shown great potential in the regulation of innate and adaptive immunity. However, role ICOS lung adenocarcinoma (LUAD) remains unclear. Methods: We used data from Cancer Genome Atlas(TCGA) database to identify expression prognostic LUAD. The results were validated using Gene Expression Omnibus(GEO) Kaplan-Meier plotter databases. A model with predictive performance for overall survival LUAD...
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive mesenchymal tumor in children. Herein, we describe our experience neoadjuvant therapy (NAT) subsequent surgery for treatment UESL children.To evaluate efficacy NAT explore new choice successful operation children.We retrospectively analyzed six patients newly diagnosed with unresectable who received then at center between January 2004 December 2019. The was considered if it involved large part both lobes or had...
Skeletal muscle laceration is a common injury. Repair of disrupted delicate tissue still clinical challenge for surgeons. A few different repair techniques have been reported. However, the best technique has not identified. The aim present study to compare biomechanical features in muscles identify most effective one.New Zealand white rabbits (2.5-3 kg) were euthanized and medial gastrocnemius isolated. completely transected with scalpels then repaired by 3 techniques, namely, (1) 2-strand...
The prognostic benefits and safety of extended lymphadenectomy for hilar cholangiocarcinoma remain uncertain. available evidence is still insufficient concerning its retrospective aspect. aim this study to explore the clinical effect compared regional in patients with cholangiocarcinoma. Relay-HC trial a prospective, multicenter, randomized controlled trial. Seven hundred thirty-four eligible resectable perihilar across 15 tertiary hospitals China will be randomly assigned (1:1) receive...
Abstract Renal cell carcinoma (RCC) is infrequent in the pediatric population. In addition, till date, only a few reports have summarized characteristics of RCC and differences between adult RCC. Therefore, current study aimed to investigate clinical children adolescents, identify adolescent patients through literature retrieval. The data 13 diagnosed with at Children's Hospital Zhejiang University School Medicine 2005 2019 were retrospectively analyzed. Three aged <5 years, 2 6 10 8 11...
Wilms tumor (WT) is the most common kidney cancer in infants and young children. The determination of clonality bilateral WTs critical to treatment, because lineage-independent metastatic tumors may require different treatment strategies. Here we found synchronous WT (n = 24 from 12 patients) responded differently preoperative chemotherapy. Transcriptome, whole-exome whole-genome analysis 6 demonstrated that each side was clonally independent terms somatic driver mutations, copy number...