A5100344568- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Pelvic floor disorders treatments
- Tracheal and airway disorders
- Head and Neck Anomalies
- Hernia repair and management
- Enhanced Recovery After Surgery
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Pediatric Hepatobiliary Diseases and Treatments
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Ocular Oncology and Treatments
- ATP Synthase and ATPases Research
- Vestibular and auditory disorders
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Ear Surgery and Otitis Media
- Cancer Mechanisms and Therapy
- Colorectal and Anal Carcinomas
- Nuclear Structure and Function
- Ovarian cancer diagnosis and treatment
- Glaucoma and retinal disorders
Shanghai Jiao Tong University
2014-2025
Renji Hospital
2016-2025
Shanghai Children's Hospital
2022-2023
Shanghai University of Traditional Chinese Medicine
2022
State Key Laboratory of Oncogene and Related Genes
2022
XinHua Hospital
2008-2021
Shanghai Cancer Institute
2016
Wuhan University
2012
Zhongnan Hospital of Wuhan University
2012
BACKGROUND: Our previous study found ANLN was over-expressed in colorectal cancer(CRC), however the role of CRC remained unknown. OBJECTIVE: To investigate relationship expression with clinical features and to determinate prognostic significance CRC. METHODS: The tissue adjacent normal mucosa were measured, between as well overall survival analyzed. RESULTS: overexpressed associated tumor invasion enlarged size. Furthermore, Kaplan-Meier analysis revealed that higher poorer survival....
We report the clinical outcome of surgical repair for rectovaginal fistula (RVF) carried out by one operative team. also investigate predictive factors healing.A retrospective cohort 63 patients underwent local RVF during January 2008 and December 2017 group. The features were reviewed. association between closure diverse parameters, including method, location, prior repair, diverting stoma, was analyzed.Sixty-three consecutive 80 repairs our Forty-five eventually healed after an average...
Abstract The bromodomain and extra-terminal domain inhibitors (BETi) are promising epigenetic drugs for the treatment of various cancers through suppression oncogenic transcription factors. However, only a subset colorectal cancer (CRC) cells response to BETi. We investigate additional agents that could be combined with BETi overcome this obstacle. JQ1-resistant CRC were used screening effective combination therapies JQ1. RNA-seq was performed explore mechanism synergistic effect. efficacy...
Gallbladder cancer (GBC) is a malignant tumor highly resistant to chemotherapy. MicroRNAs (miRNAs) are found extensively involved in modulation of carcinogenesis and chemoresistance. This study aimed investigate cisplatin (DDP)-susceptibility regulated by expression the miRNAs underlying pathways GBC.The microRNA-31 (miR-31) was selected microarray due biggest fold change between DDP-resistant parental cells. Ectopic overexpression miR-31 decreased cell proliferation, viability invasion...
Although proteasome inhibitors such as bortezomib had significant therapeutic effects in multiple myeloma and mantel cell lymphoma, they exhibited minimal clinical activity a monotherapy for solid tumors, including colorectal cancer. We found this study that inhibition induced remarkable nuclear exportation of ubiquitinated proteins. Inhibition CRM1, the export carrier protein, hampered protein synergistically enhanced cytotoxic action on colon cancer cells containing wild-type p53, which...
Adolescents and young adults (AYAs) diagnosed with cancer between ages 15~45 years may exhibit unique biologic genomic characteristics as well clinical features, resulting in differences characters drug resistance. However, compared to other solid cancers, relatively few studies have been conducted this age group cholangiocarcinoma (CCA). This study is investigate the molecular features of AYAs CCA. Three cohorts, including external dataset (TCGA MSKCC) perihilar CCA databank Chinese...
INTRODUCTION Meshes have been applied in abdominal hernia repair for lower recurrence rate and less postoperative pain. According to several guidelines, tension-free has considered the gold standard repair.[1] However, complications related mesh implantation still exist, such as late-onset deep infection. This rare complication was first defined by Mann et al. 1998.[2] Since then, similar cases reported. Late-onset infection is acute inflammatory response surgical area within months or years...
Abstract Background Three‐dimensional visualization preoperative evaluation ( 3D‐VPE) and enhanced recovery after surgery (ERAS) have been suggested to improve outcomes of cancer in patients, yet little is known regarding their clinical benefit patients with gallbladder (GBC). We hypothesized that the combination 3D‐VPE ERAS would outcome undergoing for GBC. Objective This study aimed determine if can overall survival GBC, establishing a novel patient management strategy Methods A total 227...
Abstract Gallbladder cancer (GBC) is the leading malignancy of biliary system showing refractory chemoresistance to current first‐line drugs. Growing epidemiological evidences have established that incidence GBC exhibits significant gender predominance with females two‐threefold higher than males, suggesting oestrogen/oestrogen receptors (ERs) signalling might be a critical driver tumorigenesis in gallbladder. This study aims evaluate antitumour activity tamoxifen (TAM), major agent hormonal...
Patients' satisfaction is an increasingly important indicator for successful ear reconstruction surgeries. However, there no scientifically sound patient-based outcome instrument in this field. This study aims at developing a patient-reported measure microtia investigating patients' and perception of reconstructed clinical researches.The development questionnaire included 3 stages. Traditional psychometric tests were used analysis. At first stage, preliminary version the was developed using...
Abstract Background Gallbladder cancer (GBC) is known for its high malignancy and multidrug resistance. Previously, we uncovered that impaired integrity stability of the elongator complex leads to GBC chemotherapy resistance, but whether restoration can be an efficient therapeutic strategy remains unknown. Methods RT-qPCR, MS-qPCR ChIP-qPCR were used evaluate direct association between ELP5 transcription DNA methylation in tumour non-tumour tissues GBC. EMSA, chromatin accessibility assays,...
The prognostic benefits and safety of extended lymphadenectomy for hilar cholangiocarcinoma remain uncertain. available evidence is still insufficient concerning its retrospective aspect. aim this study to explore the clinical effect compared regional in patients with cholangiocarcinoma. Relay-HC trial a prospective, multicenter, randomized controlled trial. Seven hundred thirty-four eligible resectable perihilar across 15 tertiary hospitals China will be randomly assigned (1:1) receive...
Objective To investigate the changes of predictive ocular motor function in patients with Parkinson's disease(PD),and to discuss its clinical value.Methods Videonystagmography(VNG)Was used examine 24 idiopathic disease,15 males and 9 females,aged 61 ±6(50-69),and sex age-matched healthy control subjects on random saccade(with target moving at intervals positions)and 1.25-second light 10 degrees right or left from center).Result In saccade program,the latency PD was 284 ms ±58...
Advanced Metabolic Analysis In article number 2101220, Qian, Fan, Jia, and co-workers have developed a nanoparticle enhanced laser desorption/ionization mass spectrometry platform to record aqueous humor metabolic fingerprinting (AH-MF) of retinoblastoma (RB) with high performance. Early advanced RB patients are differentiated by machine learning AH-MF identified biomarkers area-under-the-curve over 0.9 accuracy 80%. This work will contribute analysis eye diseases.