A5101824956- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Molecular Biology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced X-ray and CT Imaging
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Chromosomal and Genetic Variations
- Neurosurgical Procedures and Complications
- Connective Tissue Growth Factor Research
- Genomics, phytochemicals, and oxidative stress
- Cardiac Valve Diseases and Treatments
Shanghai Pulmonary Hospital
2020-2025
Tongji University
2020-2025
Renji Hospital
2022-2025
Shanghai Jiao Tong University
2017-2025
Putian University
2023-2024
Hong Kong Polytechnic University
2024
Henan University
2024
Southwest Hospital
2019-2023
Shandong University
2023
Army Medical College
2022
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through Silk Road. Complementing silkworm genome sequence, here we describe a mulberry species Morus notabilis. In 330-Mb assembly, identify 128 Mb repetitive sequences 29,338 genes, 60.8% which are supported by transcriptome sequencing. Mulberry gene appear to evolve ~3 times faster than other Rosales, perhaps facilitating species' spread worldwide. The tree is among...
Postoperative epidural adhesion remains a clinically challenging problem in spine surgery. Currently there are no effective and safe antifibrotic antiadhesion biomaterials that have been specifically developed for this complication clinical practice. Herein we designed engineered an advanced hydrogel with multiple functionalities, including temperature-responsive gelation, self-healing, tissue adhesiveness, antioxidation, anti-inflammation, antifibrosis. This multifunctional supramolecular...
BackgroundThe synergistic effect of locoregional therapy in combination with systemic as a conversion for unresectable hepatocellular carcinoma (uHCC) is unclear. The purpose this study was to evaluate the efficacy and safety transcatheter arterial chemoembolisation (TACE) combined lenvatinib camrelizumab (TACE + LEN CAM) uHCC.MethodsThis single-arm, multicentre, prospective conducted at nine hospitals China. Patients (aged 18–75 years) diagnosed uHCC, an Eastern Cooperative Oncology Group...
Abstract It remains a significant challenge to construct tracheal substitute with both native‐like structure and multiple essential physiological functions. In this study, combination of 3D printing techniques modular strategy is employed fabricate an engineered trachea, in which the decellularized extracellular matrix particles (DEPs) from diverse sources determined specific regenerative environments different spatial regions. Costal cartilage‐derived DEPs are integrated within cartilage...
Acute and chronic inflammation often leads to fibrosis, which is also the common final pathological outcome of inflammatory diseases. To explore genes pathogenic pathways among different fibrotic diseases, we collected all reported eight diseases: eye heart hepatic intestinal lung pancreas renal skin fibrosis. We calculated Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) enrichment scores disease genes. Each gene was encoded using KEGG GO scores, reflected how much a can affect...
A practical strategy for engineering a trachea-like structure that could be used to repair or replace damaged injured trachea is an unmet need. Here, we fabricated bioengineered cartilage (BC) rings from three-dimensionally printed fibers of poly(ɛ-caprolactone) (PCL) and rabbit chondrocytes. The extracellular matrix (ECM) secreted by the chondrocytes combined with PCL formed "concrete-rebar structure," ECM deposited along fibers, forming grid similar native cartilage. fiber-hydrogel were...
Abstract Small noncoding RNAs (sRNA/sncRNAs) are generated from different genomic loci and play important roles in biological processes, such as cell proliferation the regulation of gene expression. Next-generation sequencing (NGS) has provided an unprecedented opportunity to discover quantify diverse kinds sncRNA, tRFs (tRNA-derived small RNA fragments), phasiRNAs (phased, secondary, small-interfering RNAs), Piwi-interacting (piRNAs) plant-specific 24-nt short interfering (siRNAs). However,...
Background We investigated the prognostic effects and their patterns of immune infiltration hippo pathway core genes in lung squamous cell carcinoma, order to find some clues for underlying mechanisms LUSC tumorigenesis help developing new therapeutic methods. Methods The mutational data, transcriptome data corresponding clinical medical information patients were extracted from Cancer Genome Atlas (TCGA) database. Differential expression (DEGs) Gene Ontology (GO), Kyoto Encyclopedia Genes...
Abstract Background Pulmonary lymphoepithelioma‐like carcinoma (LELC) is a rare subtype of primary lung cancer. The present study aims at investigating clinicopathological features and prognostic characteristics the resected pulmonary LELC. Methods Patients with LELC were identified in our hospital from December 2008 to 2018. Data these patients retrospectively reviewed, analyzed subsequently. Results In total, 86 enrolled study, including 39 (45.3%) males 47 (54.7%) females. Most serum...
This study aims to elucidate the process and internal mechanism of place identity construction in traditional villages under impact tourism by taking Cuandixia village as a case. The research methods comprise participatory observation in-depth interviews with residents. main results are follows: on is mainly reflected space reconstruction, livelihood change, social relations restructuring culture change; tourism, representation residents’ shows complexity, positive negative effects;...
Tracheal defects lead to devastating problems, and practical clinical substitutes that have complex functional structures can avoid adverse influences from exogenous bioscaffolds are lacking. Herein, a modular strategy for scaffold-free tracheal engineering is developed. A cartilage sheet (Cart-S) prepared by high-density culture laminated reshaped construct tube as the main load-bearing structure in which chondrocytes exhibit stable phenotype secreted considerable cartilage-specific matrix,...
Salinization is one of the major factors that threaten existence plants worldwide. Populus euphratica has been deemed to be a promising candidate for stress response research because its high capacity tolerate extreme salt stress. We carried out genome-wide transcriptome analysis identify differentially expressed genes (DEGs) shock and elucidate early tolerance mechanisms in P. euphratica. Both hierarchical clustering DEG demonstrated predominant variation from time-course rather than NaCl...
Semantic segmentation plays a crucial role in practical applications, such as autonomous driving and robot navigation. However, prevalent semantic networks suffer from two primary challenges: oversized with redundant parameters that hinder network inference speed excessively lightweight structures sacrifice accuracy. Therefore, it is essential to design strikes balance between accuracy speed. We propose the asymmetric residual bottleneck module, which incorporates dilated convolution,...
Background: Endoscopic ultrasonography (EUS) is widely used as a staging modality for gastric cancer. However, the results of studies on use EUS N in cancer vary. This study aimed at studying overall diagnostic accuracy Methods: Published were identified through searching MEDLINE, Web Science, EMBASE, SpringerLink and ScienceDirect databases. A bivariate random effect model was to estimate sensitivity, specificity, positive likelihood ratio (PLR), negative (NLR), odds (DOR). hierarchical...
Abstract In plants, 24 nucleotide small interfering RNAs (24-nt siRNAs) account for a large percentage of the total siRNA pool, and they play an important role in guiding plant-specific RNA-directed DNA methylation (RdDM), which transcriptionally silences transposon elements, transgenes, repetitive sequences some endogenous genes. Several loci plant genomes produce clusters 24-nt RNAs, these are receiving increasing attention from research community. However, at present there is no...
Poplar is not only an important resource for the production of paper, timber and other wood-based products, but it has also emerged as ideal model system studying woody plants. To better understand biological processes underlying various traits in poplar, e.g., wood development, a comprehensive functional gene interaction network highly needed. Here, we constructed genome-wide poplar (covering ~70% 41,335 genes) created web service PoplarGene, offering interactions extensive annotations....
Background: Ubiquitin Specific Peptidase 28 (USP28), as a member of the DUBs family, has been reported to regulate occurrence and development some tumors, but its oncogenic role in tumor immunity is still unknown. Methods: The comprehensive view USP28 expression normal samples was obtained from public databases, including Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Cell Line Encyclopedia (CCLE). We analyzed genomic alterations various cancers using cBioPortal dataset....