A5015878775- Genomics and Phylogenetic Studies
- Experimental Behavioral Economics Studies
- Plant Molecular Biology Research
- SARS-CoV-2 and COVID-19 Research
- Opinion Dynamics and Social Influence
- HIV Research and Treatment
- Game Theory and Applications
- interferon and immune responses
- Plant Reproductive Biology
- Auction Theory and Applications
- Microbial Metabolism and Applications
- Ubiquitin and proteasome pathways
- Plant Virus Research Studies
- HIV/AIDS drug development and treatment
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Chromosomal and Genetic Variations
- T-cell and B-cell Immunology
- RNA Interference and Gene Delivery
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Microbial Community Ecology and Physiology
- Complex Network Analysis Techniques
- Economic Policies and Impacts
Shantou University
2025
Shantou University Medical College
2025
Peking University Shenzhen Hospital
2025
China Academy of Chinese Medical Sciences
2023-2024
Center for Life Sciences
2014-2023
Tsinghua University
2014-2023
University of Washington
2011-2023
Peking University
2021-2023
Peking University Third Hospital
2021-2023
Lanzhou University
2023
MCScan is an algorithm able to scan multiple genomes or subgenomes in order identify putative homologous chromosomal regions, and align these regions using genes as anchors. The MCScanX toolkit implements adjusted for detection of synteny collinearity that extends the original software by incorporating 14 utility programs visualization results additional downstream analyses. Applications several sequenced plant gene families are shown examples. can be used effectively analyze chromosome...
The Gossypium genus is used to investigate emergent consequences of polyploidy in cotton species; comparative genomic analyses reveal a complex evolutionary history including interactions among subgenomes that result genetic novelty elite cottons and provide insight into the evolution spinnable fibres. A phylogenetic study plants provides insights role angiosperm evolution, specifically, emergence fibres domesticated cottons. authors show an abrupt five- sixfold ploidy increase about 60...
Many proteins that respond to DNA damage are recruited lesions. We used a proteomics approach coupled isotopic labeling with chromatin fractionation and mass spectrometry uncover associate damaged DNA, many of which involved in repair or nucleolar function. show polycomb group members by poly(ADP ribose) polymerase (PARP) lesions following UV laser microirradiation. Loss components results IR sensitivity mammalian cells Caenorhabditis elegans . PARP also recruits two the repressive...
We examine the informal exchange of favors in societies such that any two individuals interact too infrequently to sustain exchange, but social pressure possible loss multiple relationships can exchange. Patterns are locally enforceable and renegotiation-proof necessitate all links “supported”: exchanging have a common friend. In symmetric settings, robust networks “social quilts”: tree-like unions completely connected subnetworks. Examining favor 75 villages rural India, we find high levels...
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through Silk Road. Complementing silkworm genome sequence, here we describe a mulberry species Morus notabilis. In 330-Mb assembly, identify 128 Mb repetitive sequences 29,338 genes, 60.8% which are supported by transcriptome sequencing. Mulberry gene appear to evolve ~3 times faster than other Rosales, perhaps facilitating species' spread worldwide. The tree is among...
Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical and clinical studies. Here, we describe new lipid-like nanoparticles (TT-LLNs) developed through an orthogonal array design, which demonstrates improved efficiency mRNA encoding luciferase in vitro by over 350-fold with significantly reduced experimental workload. One optimized TT3 LLN, termed O-TT3 LLNs, was able to restore the human factor IX (hFIX) level normal physiological values FIX-knockout mice....
Abstract How do social networks influence the decision to migrate? Prior work suggests two distinct mechanisms that have historically been difficult differentiate: as a conduit of information, and source economic support. We disentangle these using massive “digital trace” dataset allows us observe migration decisions made by millions individuals over several years, well complete network each person in months before after migration. These data allow establish new set stylized facts about...
The regulation of gene expression by the hormone auxin is a crucial mechanism in plant development. We have shown that Arabidopsis F-box protein TIR1 receptor for auxin, and our recent structural work has revealed molecular perception. substrate ubiquitin–ligase complex SCF . Auxin binding enhances interaction between its substrates, Aux/IAA repressors, thereby promoting ubiquitination degradation Aux/IAAs, altering hundreds genes. prototype new class first example an ubiquitin-ligase...
Background Both single gene and whole genome duplications (WGD) have recurred in angiosperm evolution. However, the evolutionary effects of different modes duplication, especially regarding their contributions to genetic novelty or redundancy, been inadequately explored. Results In Arabidopsis thaliana Oryza sativa (rice), species that deeply sample botanical diversity for which expression data are available from a wide range tissues physiological conditions, we compared divergence between...
Abstract Standard models of labor supply predict that unearned income decreases supply. We propose an alternative noncooperative household model in which a woman’s improves her autonomy within the household, raises gains from working and can increase find empirical support for this model, using women’s exposure to Hindu Succession Act India as source exogenous variation their income. Exposure increases by between 3.8 6.1 percentage points, particularly into high-paying jobs. Autonomy...
Cellular immunity is important in determining the disease severity of COVID-19 patients. However, current understanding SARS-CoV-2 epitopes mediating cellular limited. Here we apply T-Scan, a recently developed method, to identify CD8+ T cell from patients four major HLA-A alleles. Several identified are conserved across human coronaviruses, which might mediate pre-existing SARS-CoV-2. In addition, and validate that were mutated newly circulating variants, including Delta variant. The...
Abstract Herd immunity achieved through mass vaccination is an effective approach to prevent contagious diseases. Nonetheless, emerging SARS-CoV-2 variants with frequent mutations largely evaded humoral induced by Spike-based COVID-19 vaccines. Herein, we develop a lipid nanoparticle (LNP)-formulated mRNA-based T-cell-inducing antigen, which targeted three proteome regions that enriched human HLA-I epitopes (HLA-EPs). Immunization of HLA-EPs induces potent cellular responses infection in...
Minimized beta hairpins have provided additional data on the geometric preferences of Trp interactions in TW-loop-WT motifs. This motif imparts significant fold stability to peptides as short 8 residues. High-resolution NMR structures a 16- (KKWTWNPATGKWTWQE, DeltaG(U)(298) >or= +7 kJ/mol) and 12-residue (KTWNPATGKWTE, = +5.05 hairpin reveal common turn geometry edge-to-face (EtF) packing cation-pi interaction between Lys(1) residue nearest C-terminus. The magnitude CD exciton couplet (due...