A5100449499- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Metastasis and carcinoma case studies
- AI in cancer detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
Shanghai Pulmonary Hospital
2016-2025
Tongji University
2016-2025
Shanghai Jiao Tong University
2013-2025
Peking Union Medical College Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Southern Medical University
2024-2025
Ruijin Hospital
2025
Sichuan University
2021-2024
West China Hospital of Sichuan University
2021-2024
First Hospital of Lanzhou University
2020-2024
According to the lung cancer staging project, T1a (≤ 2 cm) non-small-cell (NSCLC) should be additionally classified into ≤ 1 cm and > groups. This study aimed investigate surgical procedure for NSCLC cm.We identified 15,760 patients with T1aN0M0 after surgery from Surveillance, Epidemiology, End Results database. Overall survival (OS) cancer-specific (LCSS) were compared among lobectomy, segmentectomy, or wedge resection. The proportional hazards model was applied evaluate multiple...
<h3>Importance</h3> There is a lack of studies exploring the performance deep learning survival neural network in non–small cell lung cancer (NSCLC). <h3>Objectives</h3> To compare performances DeepSurv, with tumor, node, and metastasis staging system prediction test reliability individual treatment recommendations provided by network. <h3>Design, Setting, Participants</h3> In this population-based cohort study, learning–based algorithm was developed validated using consecutive cases newly...
Abstract Background Microplastic pollution has become a serious global environmental threat. The abundance of microplastics in the air is an order magnitude higher than that other media, which means all living animals breathing with lungs (including humans) cannot escape fate inhaling microplastics. However, there no direct evidence to demonstrate what type and exist lung tissue. In addition, whether retention long-term friction between tissue are related some respiratory diseases largely...
The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher dynamics LUAD development. We found that T follicular helper (Tfh)-like cells, germinal center B dysfunctional CD8+ cells increase tumor initiation/invasion form tertiary lymphoid structure (TLS) inside tumor. This TLS starts with an aggregation CD4+ generation CXCL13-expressing Tfh-like followed by...
Diagnosing lung cancer from indeterminate pulmonary nodules (IPLs) remains challenging. In this multi-institutional study involving 2032 participants with IPLs, we integrate the clinical, radiomic circulating cell-free DNA fragmentomic features in 5-methylcytosine (5mC)-enriched regions to establish a multiomics model (clinic-RadmC) for predicting malignancy risk of IPLs. The clinic-RadmC yields an area-under-the-curve (AUC) 0.923 on external test set, outperforming single-omics models, and...
// Yijiu Ren 1, * , Chenyang Dai Hui Zheng 1 Fangyu Zhou Yunlang She Gening Jiang Ke Fei Ping Yang 2 Dong Xie Chang Chen Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School Medicine, Shanghai, People’s Republic China Division Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, MN, USA These authors contributed equally to this work Correspondence to: Chen, email: changchenc@hotmail.com Xie, kongduxd@163.com Keywords: lung cancer, distant...
Highlights•Notch signaling is activated in type II cells after Pseudomonas aeruginosa injury•After peak Notch activation, Dlk1 inhibits signaling•Dlk1 disruption impairs II-to-type I cell transition•Dlk1 inhibition of necessary for the repair alveolar injurySummaryLung (AT1) and (AT2) regulate structural integrity function alveoli. AT1, covering ∼95% surface area, are responsible gas exchange, whereas AT2 serve multiple functions, including through proliferation differentiation into AT1....
Background Radiomics-based biomarkers enable the prognostication of resected non–small cell lung cancer (NSCLC), but their effectiveness in clinical stage and pathologic IA pure-solid tumors requires further determination. Purpose To construct an efficient radiomics signature for survival risk stratification personalized patients with NSCLC. Materials Methods In this retrospective study, six signatures were constructed NSCLC who underwent resection between January 2011 December 2013 at...
Background Preoperative mediastinal staging is crucial for the optimal management of clinical stage I non–small cell lung cancer (NSCLC). Purpose To develop a deep learning signature N2 metastasis prediction and prognosis stratification in NSCLC. Materials Methods In this retrospective study conducted from May 2020 to October population with NSCLC, an internal cohort was adopted establish signature. Subsequently, predictive efficacy biologic basis proposed were investigated external cohort....
In December 2019, the outbreak of a new coronavirus-caused pneumonia (COVID-19) in Wuhan attracted close attention China and world. The Chinese government took strong national intervention measures on January 23 to control spread epidemic. We are trying show impact these controls proposed an SEIR(Susceptible-Exposed-Infectious-Removed) model analyze epidemic trend use AI non-Wuhan areas. found that if closure was lifted, areas mainland would double size. Our SEIR effective predicting...
BackgroundThis study, based on multicentre cohorts, aims to utilize computed tomography (CT) images construct a deep learning model for predicting major pathological response (MPR) neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC) and further explore the biological basis under its prediction.Methods274 patients undergoing curative surgery after NSCLC at 4 centres from January 2019 December 2021 were included divided into training cohort, an internal validation external...
Occult nodal metastasis (ONM) plays a significant role in comprehensive treatments of non-small cell lung cancer (NSCLC). This study aims to develop deep learning signature based on positron emission tomography/computed tomography predict ONM clinical stage N0 NSCLC. An internal cohort (n = 1911) is included construct the (DLNMS). Subsequently, an external 355) and prospective 999) are utilized fully validate predictive performances DLNMS. Here, we show areas under receiver operating...
Abstract OBJECTIVES As evidence has proven that sublobar resection is oncologically contraindicated by tumour spread through air spaces (STAS), its preoperative recognition vital in customizing surgical strategies. We aimed to assess the value of radiomics predicting STAS stage I lung adenocarcinoma. METHODS retrospectively reviewed patients with adenocarcinoma, who accepted curative our institution between January 2011 and December 2013. Using ‘PyRadiomics’ package, 88 features were...
Abstract The loss of normal alveolar capillary and deregulated angiogenesis occurs simultaneously in idiopathic pulmonary fibrosis (IPF); however the contributions specific endothelial subpopulations development are poorly understood. Herein, we perform single-cell RNA sequencing to characterize heterogeneity cells (ECs) bleomycin (BLM)-induced lung rats. One subpopulation, characterized by expression Nos3 Cav1, is mostly distributed non-fibrotic lungs also highly expresses genes related...