A5069651727- Sexual function and dysfunction studies
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Genital Health and Disease
- MicroRNA in disease regulation
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Pelvic floor disorders treatments
- Anesthesia and Pain Management
- Sperm and Testicular Function
- Diabetes Treatment and Management
- Lung Cancer Treatments and Mutations
- Inflammatory Bowel Disease
- Renal and related cancers
- Gastric Cancer Management and Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Magnetic Properties and Applications
- Reproductive System and Pregnancy
Beijing Tian Tan Hospital
2018-2025
Capital Medical University
2013-2025
Kunming University of Science and Technology
2025
Peking University
2025
Sartorius (United States)
2024
Tianjin First Center Hospital
2024
Tianjin Medical University
2024
Second Hospital of Tianjin Medical University
2024
Nankai University
2024
Jinling Institute of Technology
2024
Background: Prostate cancer (PCa) is one of the most common malignancies in men with a poor prognosis. It therefore great clinical importance to find reliable prognostic indicators for PCa. Many studies have revealed pivotal role protein lactylation tumor development and progression. This research aims analyze effect lactylation-related genes on PCa Methods: By downloading mRNA-Seq data TCGA PCa, we obtained differential related Five machine learning algorithms were used screen key then five...
Prostate adenocarcinoma (PCa) is the most common cause of death due to malignancy among men, and bone metastasis leading mortality in patients with PCa. Therefore, identifying causes molecular mechanism important for early detection, diagnosis personalized therapy. In this study, we systematically analyzed correlates by bioinformatics analysis. A total 12 differentially expressed microRNAs (miRNAs) 102 genes were identified. Five miRNAs had prognostic significance biochemical recurrence-free...
Recent data showed that a six-domain UPOINT is flexible and responsive new classification system has the clinical applicability in CP/CPPS. However, utility of algorithm men China with CP/CPPS not been comprehensively studied. For international validation adoption, we evaluated this phenotype for large cohort Chinese patients correlated it patient symptoms erectile dysfunction (ED). We also investigated addition an ED domain regard to symptom correlation.A total 389 males were prospectively...
The investigation of underlying mechanism and the exploitation novel therapies for metastatic prostate cancer (PCa) are still urgently needed. miR-199b-5p has been suggested to function as tumour suppressor in various human cancers. However, clinical significance role PCa remain unclear.The current study sought investigate expression status involved molecular mechanisms metastasis by using bioinformatics analyses, loss-and gain-of-functions rescue experiments vitro vivo.We demonstrated that...
Purpose: Prostate cancer (PCa) is often considered as a âcoldâ tumor with low responsiveness to immunotherapy. Recent evidence suggests the activation of specific immune cells, such tumor-associated macrophages (TAMs), could potentially influence efficacy immunotherapy in PCa. However, relationship between TAMs and PD-L1, significant regulator immunotherapy, within PCa remains unexplored. Methods: In this study, we assessed TAM infiltration PD-L1 expression levels local cohort 95 tissue...
Beta-blockers are widely used, with continuously updated clinical recommendations. However, their application faces challenges in personalized treatment and safety. The study aimed to investigate the frequency patterns of prescribing beta-blockers China explore potential adverse event risk signals associated beta-blockers, providing reference for rational medication use settings. Prescription data from January 2018 June 2023 were extracted through Hospital Analysis Collaborative Project...
Background The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)‐anchored protein. Increasing evidence has indicated PSCA plays an important role in tumorigenesis. However, its function and the underlying molecular mechanisms prostate cancer (PCa) are still not fully elucidated. In this study, we aimed to explore effect of on cycle PCa cells mechanism research. Methods Immunohistochemistry, quantitative reverse transcription‐PCR (qRT‐PCR) Western blotting were used...
Erectile dysfunction (ED) is a common ageing male's disease, and vascular ED accounts for the largest proportion of all types ED. One mechanisms in clinic arterial insufficiency, which mainly caused by atherosclerosis, trauma surgical. Moreover, oxidative stress damage after tissue ischemia usually aggravated progress As new way acellular therapy, mesenchymal stem cell-derived exosomes (MSC-Exos) have great potential treatment. In current study, we explored mechanism MSC-Exos therapy rat...
ABSTRACT Traditionally, it is well known that the lowest‐order and pole‐order (2 p th‐order) radial forces play a leading role in vibration response of fractional‐slot concentrated‐winding (FSCW) permanent magnet synchronous machines (PMSMs). However, this study reveals force at nonswitching high‐frequency band dominant source. First, characteristic 10‐slot/8‐pole FSCW PMSM described. A phenomenon revealed through acceleration, which different from traditional theory cognition. The (PM)...
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability and unpredictable clinical behavior.GBM marked an extremely poor prognosis with median overall survival 12∼14 months.In this study, we detected CD137L-expressing cells IL-17-expressing in tumor tissues resected from patients GBM.Expression CD137L IL-17 were assessed immunohistochemistry, prognostic value expression within Cox regression Kaplan-Meier analysis.Immunohistochemical...